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폐쇄성 수면무호흡증 환자에서 하지불안증후군과 우울, 불안 및 불면과의 연관성

Association of Restless Legs Syndrome with Depression, Anxiety, and Insomnia in Patients with Obstructive Sleep Apnea Syndrome

김재민|윤진상|배경열|김성완|신일선|김주완
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2016.10|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제22권 제3호|pp. 237-245

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참고문헌

키워드

우울Depression불안폐쇄성 수면무호흡증AnxietyInsomnia불면하지불안증후군Obstructive sleep apnea syndromeRestless legs syndrome
주제분류정신과학

초록

Objectives：An association between obstructive sleep apnea syndrome(OSAS) and restless legs syndrome(RLS) has long been reported. Both syndromes are associated with depression, anxiety, insomnia, and daytime sleepiness. However, these relationships have not been studied extensively, and many questions remain unanswered. This study investigated the prevalence of RLS and its association with depression, anxiety, insomnia, and daytime sleepiness in OSAS patients in Korea. Methods：The study enrolled 152 Korean OSAS in patients Chonnam National University Hospital. The International Restless Legs Syndrome Study Group criteria and International Restless Legs Scale were used to determine the diagnosis and severity of RLS. To assess depression, anxiety, insomnia, and day time sleepiness, all patients completed the Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Insomnia Severity Index(ISI), and Epworth Sleepiness Scale(ESS). Results：Overall, 65(42.6%) patients met least one of the RLS diagnostic criteria, and 17(11.1%) were diagnosed with RLS. The mean BDI, BAI, and ISI scores were higher in subjects with RLS symptoms compared with those without such symptoms. ESS scores were not significantly associated with RLS symptoms. There were significant positive correlations between RLS severity and BDI(r=0.246, p=0.049), BAI(r=0.247, p=0.031), and ISI(r=0.275, p=0.026) scores. Conclusion：There were significant relationships between RLS symptoms and depression, anxiety, and insomnia. We recommend that patients with OSAS be evaluated for symptoms of RLS.

Abstract

Objectives：An association between obstructive sleep apnea syndrome(OSAS) and restless legs syndrome(RLS) has long been reported. Both syndromes are associated with depression, anxiety, insomnia, and daytime sleepiness. However, these relationships have not been studied extensively, and many questions remain unanswered. This study investigated the prevalence of RLS and its association with depression, anxiety, insomnia, and daytime sleepiness in OSAS patients in Korea. Methods：The study enrolled 152 Korean OSAS in patients Chonnam National University Hospital. The International Restless Legs Syndrome Study Group criteria and International Restless Legs Scale were used to determine the diagnosis and severity of RLS. To assess depression, anxiety, insomnia, and day time sleepiness, all patients completed the Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Insomnia Severity Index(ISI), and Epworth Sleepiness Scale(ESS). Results：Overall, 65(42.6%) patients met least one of the RLS diagnostic criteria, and 17(11.1%) were diagnosed with RLS. The mean BDI, BAI, and ISI scores were higher in subjects with RLS symptoms compared with those without such symptoms. ESS scores were not significantly associated with RLS symptoms. There were significant positive correlations between RLS severity and BDI(r=0.246, p=0.049), BAI(r=0.247, p=0.031), and ISI(r=0.275, p=0.026) scores. Conclusion：There were significant relationships between RLS symptoms and depression, anxiety, and insomnia. We recommend that patients with OSAS be evaluated for symptoms of RLS.

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