Non-disturbing of Decidual Response by Steroid Hormonal Complexes of Pig Testis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.
Abstract
Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.
참고문헌 (22)
- 플러더블유베이저, "Novel pathways for implantation and establishment and maintenance of pregnancy in mammals", MOLECULAR HUMAN REPRODUCTION, 16(3), pp.135~152, OXFORD UNIV PRESS
- Brosens JJ, "Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells", Endocrinology, 140, pp.4809~4820 (1999)
- Carson DD, "Embryo implantation", Dev Biol, 223, pp.217~237 (2000)
- 전용필, "Androgen in the Uterus: A Compensator of Estrogen and Progesterone", 발생과 생식, 13(3), pp.133~143 (2009), 한국발생생물학회
- Cheon YP, "A genomic approach to identify novel progesterone receptor regulated pathways in the uterus during implantation", Mol Endocrinol, 16, pp.2853~2871 (2002)
- Cheon YP, "Induction of cytotoxic T-lmphocyte antigen-2beta, a cysteine protease inhibitor in deciduas: a potential regulator of embryo implantation", J Biol Chem, 279, pp.10357~10363 (2004)
- Clark AS, "Behavioral and physiological responses to anabolic-androgenic steroids", Neurosci Biobehav Rev, 27, pp.413~436 (2003)
- Clark AS, "Sex- and age-specific effects of anabolic androgenic steroids on reproductive behaviors and on GABAergic transmission in neuroendocrine control regions", Brain Res, 1126, pp.122~138 (2006)
- Gellersen B, "Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives", Semin Reprod Med, 25, pp.445~453 (2007)
- Grümmer R, "Regulation of connexin26 and connexin43 expression in rat endometrium by ovarian steroid hormones", Biol Reprod, 51, pp.1109~1116 (1994)
- Grümmer R, "Expression pattern of different gap junction connexins is related to embryo implantation", Int J Dev Biol, 40, pp.361~367 (1996)
- Ishak KG, "Drug-induced and toxic granulomatous hepatitis", Bailliere's Clin Gastroenterol, 2, pp.463~480 (1988)
- Ledford BE, "Biochemical and morphological changes following artificially stimulated deecidualization in the mouse uterus", Biol Reprod, 15, pp.529~535 (1976)
- 이동목, "돼지 고기의 아나볼릭 스테로이드가 Myogenic Satellite Cell의 증식과 분화에 미치는 영향", 한국축산식품학회지, 30(5), pp.842~850 (2010), 한국축산식품학회
- Lukas SE, "Current perspectives on anabolic–androgenic steroid abuse", Trends Pharmacol Sci, 14, pp.61~68 (1993)
- Mori M, "Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice", J Clin Invest, 121, pp.318~327 (2011)
- Mustafa R, "Drug-induced hirsutism", J Coll Physicians Surg Pak, 16, pp.485~486 (2006)
- Ozturk S, "Particular functions of estrogen and progesterone in establishment of uterine receptivity and embryo implantation", 25, pp.1215~1228 (2010)
- Psychoyos A, "Uterine receptivity for nidation", Acad Sci, 476, pp.36~42 (1986)
- Ramathal CY, "Endometrial decidualization: of mice and men", Semin Reprod Med, 28, pp.17~26 (2010)
- Rockhold RW, "Cardiovascular toxicity of anabolic steroids", Annu Rev Pharmacol Toxicol, 33, pp.497~520 (1993)
- Witte DP, "Coordinate developmental regulation of purine catabolic enzyme expression in gastrointestinal and postimplantation reproductive tracts", J Cell Biol, 115, pp.179~190 (1991)