노인에서 성별에 따른 알코올사용장애와 인지기능의 관계
Association between Alcohol Use Disorder and Cognitive Function According to Gender in the Elderly
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective：This study aims to investigate the association between alcohol use disorder and cognition in Korean communitydwelling elderly, especially the gender-specific difference. Methods：Data obtained from 1,141 subjects (976 men and 165 women) aged above 60 years was analyzed from the Gwangju Dementia and Mild Cognitive Impairment Study. All subjects completed the study questionnaire including demographic characteristics, history of current and past illnesses, drug history, Korean Mini-Mental State Examination (K-MMSE), and cut down, annoyed, guilty feelings, eye-opener (CAGE), Short Form of Geriatric Depression Scale-Korean version (SGDS-K). Results：Of the 1,141 subjects (mean age 72.17±6.20, mean educational level 6.50±4.48), 267 demonstrated alcohol use disorder (23.40%) and 874 were non-alcohol use disorder (76.60%). The mean of K-MMSE for alcohol use disorder group was 23.23±4.99, and for non-alcohol use disorder group was 23.70±3.94. When alcohol use disorder is accompanying, the decrement of K-MMSE score was 3.07 for female, and 0.35 for male. And we confirmed the interactive effect on K-MMSE score between sex and alcohol use disorder after adjusting for age, education level, depression (F=5.798, p=0.016). Conclusion：In conclusion, our study demonstrates an association between alcohol use disorder and cognitive impairment by gender in the elderly.
Abstract
Objective：This study aims to investigate the association between alcohol use disorder and cognition in Korean communitydwelling elderly, especially the gender-specific difference. Methods：Data obtained from 1,141 subjects (976 men and 165 women) aged above 60 years was analyzed from the Gwangju Dementia and Mild Cognitive Impairment Study. All subjects completed the study questionnaire including demographic characteristics, history of current and past illnesses, drug history, Korean Mini-Mental State Examination (K-MMSE), and cut down, annoyed, guilty feelings, eye-opener (CAGE), Short Form of Geriatric Depression Scale-Korean version (SGDS-K). Results：Of the 1,141 subjects (mean age 72.17±6.20, mean educational level 6.50±4.48), 267 demonstrated alcohol use disorder (23.40%) and 874 were non-alcohol use disorder (76.60%). The mean of K-MMSE for alcohol use disorder group was 23.23±4.99, and for non-alcohol use disorder group was 23.70±3.94. When alcohol use disorder is accompanying, the decrement of K-MMSE score was 3.07 for female, and 0.35 for male. And we confirmed the interactive effect on K-MMSE score between sex and alcohol use disorder after adjusting for age, education level, depression (F=5.798, p=0.016). Conclusion：In conclusion, our study demonstrates an association between alcohol use disorder and cognitive impairment by gender in the elderly.
참고문헌 (28)
- The epidemiological survey of mental disorders in Korea, "Cho MJ", Ministry of Health and Welfare, ~ (2012)
- Han B, "Substance use disorder among older adults in the United States in 2020", Addiction, 104, pp.88~96 (2009)
- Langa KM, "The diagnosis and management of mild cognitive impairment: a clinical review", JAMA, 312, pp.2551~2561 (2014)
- Anke Booker, "Risk factors for dementia diagnosis in German primary care practices", International Psychogeriatrics, 28(07), pp.1059~1065 (2016), Cambridge University Press (CUP)[DOI]
- Squeglia LM, "Age-related effects of alcohol from adolescent, adult, and aged populations using human and animal models", Alcohol Clin Exp Res, 38, pp.2509~2516 (2014)
- Ruitenberg A, "Alcohol consumption and risk of dementia:the Rotterdam Study", Lancet, 359, pp.281~286 (2002)
- Mukamal KJ, "Prospective study of alcohol consumption and risk of dementia in older adults", JAMA, 289, pp.1405~1413 (2003)
- Stampfer MJ, "Effects of moderate alcohol consumption on cognitive function in women", N Engl J Med, 352, pp.245~253 (2005)
- Dufouil C, "Sex differences in the association between alcohol consumption and cognitive performance. EVA Study Group. Epidemiology of Vascular Aging", Am J Epidemiol, 146, pp.405~412 (1997)
- Horvat P, "Alcohol consumption, drinking patterns, and cognitive function in older Eastern European adults", Neurology, 84, pp.287~295 (2015)
- Hoffman LA, "The effects of acute alcohol on psychomotor, set-shifting, and working memory performance in older men and women", Alcohol, 49, pp.185~191 (2015)
- Bleich S, "Homocysteine and alcoholism", J Neural Transm Suppl, (60), pp.187~196 (2000)
- Gupta S, "Alcohol-related dementia: a 21st-century silent epidemic", Br J Psychiatry, 193, pp.351~353 (2008)
- Chick JD, "Magnetic resonance imaging of the brain in alcoholics: cerebral atrophy, lifetime alcohol consumption, and cognitive deficits", Alcohol Clin Exp Res, 13, pp.512~518 (1989)
- Hoek JB, "Alcohol and mitochondria: a dysfunctional relationship", Gastroenterology, 122, pp.2049~2063 (2002)
- Harper C, "Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre", Prog Neuropsychopharmacol Biol Psychiatry, 27, pp.951~961 (2003)
- Ding J, "Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study", Stroke, 35, pp.16~21 (2004)
- Duka T, "Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients", Alcohol Clin Exp Res, 27, pp.1563~1572 (2003)
- Kim KR, "The effect of the ApoE genotype on the association between head circumference and cognition", Am J Geriatr Psychiatry, 16, pp.819~825 (2008)
- Lee KS, "Cognitive decline is associated with nutritional risk in subjects with small head circumference (HC)", Arch Gerontol Geriatr, 51, pp.105~109 (2010)
- Kim KR, "Characteristic profiles of instrumental activities of daily living in different subtypes of mild cognitive impairment", Dement Geriatr Cogn Disord, 27, pp.278~285 (2009)
- Kang Y, "A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients", J Korean Neurol Assoc, 15, pp.300~308 (1997)
- Ewing JA, "Detecting alcoholism. The CAGE questionnaire", JAMA, 252, pp.1905~1907 (1984)
- Nam JH, "Validity of CAGE for older adults with alcohol use disorder in community", J Korean Geriatr Psychiatry, 8, pp.49~55 (2004)
- Yesavage JA, "Development and validation of a geriatric depression screening scale: a preliminary report", J Psychiatr Res, 17, pp.37~49 (1982)
- Bae JN, "Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients", J Psychosom Res, 57, pp.297~305 (2004)
- Delin CR, "Drinking and the brain: current evidence", Alcohol Alcohol, 27, pp.117~126 (1992)
- Hommer DW, "Male and female sensitivity to alcohol-induced brain damage", Alcohol Res Health, 27, pp.181~185 (2003)