당뇨에 이환된 알코올 의존 환자의 신경인지기능 이상
Neurocognitive Function Impairment in Alcohol Dependent Patients with Diabetes Mellitus
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알코올 의존 환자와 당뇨병 환자 각각에서 신경인지기능의장애를 보인다는 보고는 많이 있어왔다. 본 연구에서는 알코올의존 환자에서 당뇨병이 합병되었을 때 알코올 관련 질환만가지고 있는 환자들에 비해서 더 현저한 인지기능의 저하를보였으며, 언어영역 및 작업기억과 관련된 부분에서 유의하였다. 이 결과는 임상에서 알코올 의존 환자에서 당뇨에 대한평가 및 치료를 하는 것이 환자의 인지기능 저하를 예방하는데에 중요함을 시사한다.
Abstract
Objectives Diabetes and alcohol dependence are considered as independent risk factors for cognitive impairment. This research was to investigate whether cognitive functions in diabetic alcohol dependent patients were more impaired than non-diabetic alcohol dependent patients. Methods A cross-sectional study was conducted in alcohol dependence patients (n=138). Patients with alcohol dependence diagnosed by Diagnostic and Statistical Manual of Mental Disorder, 4th edition, Text Revision underwent a 75 g oral glucose tolerance test, to classify to diabetics group and non-diabetics group. In addition to demographic and clinical characteristics, cognitive functions assessed using the Korean-Mini Mental Status Examination (K-MMSE), word list memory test, and word fluency test, word list recall test from Korean version of the consortium to establish a registry for Alzheimer’s disease, and block design test, digit span test, and digit symbol test from Korean-Wechsler Adult Intellogence Scale were compared between the two groups. Results There was no significant difference in demographic and other clinical characteristics between the non-diabetic and diabetic alcoholic patients. Compared to non-diabetic alcoholic patients, diabetic alcoholic patients were more impaired on language of K-MMSE (p=0.028) and digit symbol test (p=0.044). Conclusion These findings suggest the more severe impairment of selective cognitive functions in diabetic alcoholic patients than non-diabetic alcoholic patients. Future replication of these findings in a large population is necessary.
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