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초기 인지저하 단계에서 변화가 확인되는 신경심리영역

Neuropsychological Domains Altered at the Early Stage of Cognitive Decline

박수진|하정희|이도엽|김진현
대한노인정신의학회 (Korean Association For Geriatric Psychiatry)|2021.10|노인정신의학 (Journal of Korean Geriatric Psychiatry)|제25권 제2호|pp. 105-112

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참고문헌

키워드

치매신경심리검사Dementia인지저하Cognitive declineNeuropsychological tests질병조기발견공간기억.Early detection of diseaseSpatial memory.

초록

Objective: A neuropsychological battery is a gold standard for thorough cognitive evaluation. However, it could not be used as a screening test due to its long inspection time and high cost. This study is conducted to identify specific cognitive subdomains that alter even at the early stage of cognitive decline. Methods: Neuropsychological battery results of 575 persons who visited memory clinic were analysed. We classified stages of cognitive decline according to Clinical Dementia Rating (CDR) and CDR-Sum of boxes (CDR-SB). To explore which subdomains can sensitively distinguish normal cognition from the early cognitive impairment, we used Variable Importance in Projection (VIP) in addition to analysis of covariance. Results: We found that scores in subdomain tests such as Rey Complex Figure Test immediate and delayed recall successfully differentiate persons with CDR 0 from those with CDR 0.5 and also persons with CDR-SB 0 from those with CDR-SB 0.5 as indicated by VIP values greater than 1. Conclusion: These results suggest that alterations in visuospatial memory function might be a sensitive sign reflecting the early cognitive decline. The combination of only a few subtests could be also used as a reliable and sensitive screening tool to detect early cognitive impairment.

Abstract

Objective: A neuropsychological battery is a gold standard for thorough cognitive evaluation. However, it could not be used as a screening test due to its long inspection time and high cost. This study is conducted to identify specific cognitive subdomains that alter even at the early stage of cognitive decline. Methods: Neuropsychological battery results of 575 persons who visited memory clinic were analysed. We classified stages of cognitive decline according to Clinical Dementia Rating (CDR) and CDR-Sum of boxes (CDR-SB). To explore which subdomains can sensitively distinguish normal cognition from the early cognitive impairment, we used Variable Importance in Projection (VIP) in addition to analysis of covariance. Results: We found that scores in subdomain tests such as Rey Complex Figure Test immediate and delayed recall successfully differentiate persons with CDR 0 from those with CDR 0.5 and also persons with CDR-SB 0 from those with CDR-SB 0.5 as indicated by VIP values greater than 1. Conclusion: These results suggest that alterations in visuospatial memory function might be a sensitive sign reflecting the early cognitive decline. The combination of only a few subtests could be also used as a reliable and sensitive screening tool to detect early cognitive impairment.

참고문헌 (36)

  1. Korean Dementia Observatory 2020, "Lee JS", National Institute of Dementia, 74~, pp.Rport No.: NIDR-2002-0031 (2021)
  2. Tábuas-Pereira M, "Prognosis of early-onset vs. late-onset mild cognitive impairment: comparison of conversion rates and its predictors", Geriatrics(Basel), 1, pp.11~ (2016)
  3. Jorm AF, "Projections of future numbers of dementia cases in Australia with and without prevention", Aust N Z J Psychiatry, 39, pp.959~963 (2005)
  4. Yu SY, "Cost-effectiveness of nationwide opportunistic screening program for dementia in South Korea", J Alzheimers Dis, 44, pp.195~204 (2015)
  5. Ismail Z, "Brief cognitive screening instruments : an update", Int J Geriatr Psychiatry, 25, pp.111~120 (2010)
  6. Galasko D, "The Mini-Mental State Examination in the early diagnosis of Alzheimer’s disease", Arch Neurol, 47, pp.49~52 (1990)
  7. Malloy PF, "Cognitive screening instruments in neuropsychiatry : a report of the Committee on Research of the American Neuropsychiatric Association", J Neuropsychiatry Clin Neurosci, 9, pp.189~197 (1997)
  8. Cummings JL, "Mini-Mental State Examination. Norms, normals, and numbers", Jama, 269, pp.2420~2421 (1993)
  9. 서은현, "치매 및 인지장애에서의 신경심리평가", 신경정신의학, 57(1), pp.2~11 (2018), 대한신경정신의학회[DOI]
  10. Kang Y, "A validity study on the Korean Mini-Mental State Examination(K-MMSE)in dementia patients", J Korean Neurol Assoc, 15, pp.300~308 (1997)
  11. Folstein MF, "“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician", J Psychiatr Res, 12, pp.189~198 (1975)
  12. Choi SH, "Estimating the validity of the Korean version of expanded Clinical Dementia Rating(CDR)scale", J Korean Neurol Assoc, 19, pp.585~591 (2001)
  13. Morris JC, "The Clinical Dementia Rating(CDR) : current version and scoring rules", Neurology, 43, pp.2412~2414 (1993)
  14. Bae JN, "Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients", J Psychosom Res, 57, pp.297~305 (2004)
  15. Yesavage JA, "Development and validation of a geriatric depression screening scale : a preliminary report", J Psychiatr Res, 17, pp.37~49 (1982)
  16. Kang YW, "Seoul neuropsychological screening battery" (2012), Human Brain Research & Consulting Co
  17. Hotelling H, "Analysis of a complex of statistical variables into principal components", J Educ Psychol, 24, pp.417~441 (1933)
  18. Wold S, "PLS-regression : a basic tool of chemometrics", Chemom Intell Lab Syst, 58, pp.109~130 (2001)
  19. Martens H, "Multivariate calibration" (1989), John Wiley & Sons
  20. Wold S, "The collinearity problem in linear regression. The partial least squares (PLS) approach to generalized inverses", SIAM J Sci Stat Comput, 5, pp.735~743 (1984)
  21. Campos-Magdaleno M, "Changes in visual memory in mild cognitive impairment : a longitudinal study with CANTAB", Psychol Med, pp.1~11 (2020)
  22. Youn YC, "Use of the Clock Drawing Test and the Rey-Osterrieth Complex Figure Test-copy with convolutional neural networks to predict cognitive impairment", Alzheimer’s Res Ther, 13, pp.85~ (2021)
  23. Eun Hyun Seo, "Pre-Mild Cognitive Impairment: Can Visual Memory Predict Who Rapidly Convert to Mild Cognitive Impairment?", PSYCHIATRY INVESTIGATION, 15(9), pp.869~875 (2018), 대한신경정신의학회[DOI]
  24. 추일한, "시각 즉각 회상 검사를 이용한 지역사회 경도인지장애 조기발견", 노인정신의학, 25(1), pp.8~13 (2021), 대한노인정신의학회[DOI]
  25. Kim KW, "A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea", J Alzheimers Dis, 23, pp.281~291 (2011)
  26. Rizzo M, "Visual attention impairments in Alzheimer’s disease", Neurology, 54, pp.1954~1959 (2000)
  27. Rösler A, "Alterations of visual search strategy in Alzheimer’s disease and aging", Neuropsychology, 14, pp.398~408 (2000)
  28. Guérin F, "Characterization of visuoconstructional disabilities in patients with probable dementia of Alzheimer’s type", J Clin Exp Neuropsychol, 24, pp.1~17 (2002)
  29. Chehrehnegar N, "Early detection of cognitive disturbances in mild cognitive impairment : a systematic review of observational studies", Psychogeriatrics, 20, pp.212~228 (2020)
  30. Ravaglia G, "Screening for mild cognitive impairment in elderly ambulatory patients with cognitive complaints", Aging Clin Exp Res, 17, pp.374~379 (2005)
  31. Beinhoff U, "Screening for cognitive impairment : a triage for outpatient care", Dement Geriatr Cogn Disord, 20, pp.278~285 (2005)
  32. Petrazzuoli F, "Brief cognitive tests used in primary care cannot accurately differentiate mild cognitive impairment from subjective cognitive decline", J Alzheimers Dis, 75, pp.1191~1201 (2020)
  33. 조경화, "지역사회 거주 노인의 인지장애에 따른 우울장애 빈도", 노인정신의학, 24(1), pp.1~9 (2020), 대한노인정신의학회[DOI]
  34. Solfrizzi V, "Incident occurrence of depressive symptoms among patients with mild cognitive impairment-the Italian longitudinal study on aging", Dement Geriatr Cogn Disord, 24, pp.55~64 (2007)
  35. Herrmann LL, "The cognitive neuropsychology of depression in the elderly", Psychol Med, 37, pp.1693~1702 (2007)
  36. Lockwood KA, "Subtypes of cognitive impairment in depressed older adults", Am J Geriatr Psychiatry, 8, pp.201~208 (2000)

관련 논문AI추천

Pre-Mild Cognitive Impairment: Can Visual Memory Predict Who Rapidly Convert to Mild Cognitive Impairment?Eun Hyun Seo, Hoowon Kim, IL Han Choo, Kun Ho Lee, Kyu Yeong Choi대한신경정신의학회 · PSYCHIATRY INVESTIGATION2018 · 제15권 제9호시각 즉각 회상 검사를 이용한 지역사회 경도인지장애 조기발견추일한대한노인정신의학회 · 노인정신의학2021 · 제25권 제1호정상 노인과 경도인지장애의 감별을 위한 언어 기억과 시공간 기억 검사의 예측 성능 비교변해원한국융합학회 · 한국융합학회논문지2020 · 제11권 제6호치매임상평가척도 박스총점(CDR-SB)에 따른 기억성 경도인지장애와 혈관성 경도인지장애의 MMSE, HDS-R 및MoCA 검사 반응 비교강연욱, 김보혜대한치매학회 · Dementia and Neurocognitive Disorders(대한치매학회지)2014 · 제13권 제4호치매 및 인지장애에서의 신경심리평가서은현대한신경정신의학회 · 신경정신의학2018 · 제57권 제1호우울증 여부에 따른 경도인지장애 환자의 신경심리학적 특징 비교김성윤, 방수영, 안준호, 정광석, 최순호대한노인정신의학회 · 노인정신의학2012 · 제16권 제2호

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