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경도인지장애와 치매 환자에서 숫자 거꾸로 따라하기로 측정한 작업기억에 대한 우울증의 영향

Influence of Depression on Working Memory Measured by Digit Backward Span in the Subjects with Mild Cognitive Impairment and Dementia

한상우|이연정|김민재|우성일|황재욱|김채리|박진완|노양호
대한노인정신의학회 (Korean Association For Geriatric Psychiatry)|2015.10|노인정신의학 (Journal of Korean Geriatric Psychiatry)|제19권 제2호|pp. 79-85

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참고문헌

키워드

DepressionMild cognitive impairmentDementiaWorking memory.

초록

Objective：We aimed to explore the influence of depression on working memory in patients with mild cognitive impairment (MCI) and dementia. Methods：Clinical and neuropsychological data of 43 subjects with mild cognitive impairment (MCI) (n=17) and dementia (n= 26) who had visited Department of Psychiatry at Soonchunhyang University Seoul Hospital, were collected. The subjects were divided into depressed (n=18) and non-depressed (n=25) groups based on the Korean version of Short Geriatric Depression Scale. Two-way analysis of variance test was conducted to evaluate the influence of diagnosis (MCI and dementia), the presence of depression and their interaction on working memory which was measured by digit forward and backward span test. Results：Among the patients with MCI, test score of digit backward span test in depressed group was significantly lower than in non-depressed group. However, among the patients with dementia, there was no significant difference in digit backward span test between depressed and non-depressed groups. Conclusion：This study suggests that the depression could deteriorate working memory measured by digit backward span test in patients with MCI, relative to in patients with dementia and it also implicates the diagnostic assessment for depression has clinically importance in patients with MCI.

Abstract

Objective：We aimed to explore the influence of depression on working memory in patients with mild cognitive impairment (MCI) and dementia. Methods：Clinical and neuropsychological data of 43 subjects with mild cognitive impairment (MCI) (n=17) and dementia (n= 26) who had visited Department of Psychiatry at Soonchunhyang University Seoul Hospital, were collected. The subjects were divided into depressed (n=18) and non-depressed (n=25) groups based on the Korean version of Short Geriatric Depression Scale. Two-way analysis of variance test was conducted to evaluate the influence of diagnosis (MCI and dementia), the presence of depression and their interaction on working memory which was measured by digit forward and backward span test. Results：Among the patients with MCI, test score of digit backward span test in depressed group was significantly lower than in non-depressed group. However, among the patients with dementia, there was no significant difference in digit backward span test between depressed and non-depressed groups. Conclusion：This study suggests that the depression could deteriorate working memory measured by digit backward span test in patients with MCI, relative to in patients with dementia and it also implicates the diagnostic assessment for depression has clinically importance in patients with MCI.

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