Clinical Outcomes of Silk Patch in Acute Tympanic Membrane Perforation
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Objectives. The silk patch is a thin transparent patch that is produced from silk fibroin. In this study, we investigated the treatment effects of the silk patch in patients with traumatic tympanic membrane perforation (TTMP). Methods. The closure rate, otorrhea rate, and closure time in all patients and the closure time in successful patients were compared between the paper patch and silk patch groups. Results. Demographic data (gender, site, age, traumatic duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rate and otorrhea rate were not significantly different between the two groups. However, the closure time was different between the two groups (closure time of all patients, P=0.031; closure time of successful patients, P=0.037). Conclusion. The silk patch which has transparent, elastic, adhesive, and hyper-keratinizing properties results in a more efficient closure time than the paper patch in the treatment of TTMP patients. We therefore believe that the silk patch should be recommended for the treatment of acute tympanic membrane perforation.
Abstract
Objectives. The silk patch is a thin transparent patch that is produced from silk fibroin. In this study, we investigated the treatment effects of the silk patch in patients with traumatic tympanic membrane perforation (TTMP). Methods. The closure rate, otorrhea rate, and closure time in all patients and the closure time in successful patients were compared between the paper patch and silk patch groups. Results. Demographic data (gender, site, age, traumatic duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rate and otorrhea rate were not significantly different between the two groups. However, the closure time was different between the two groups (closure time of all patients, P=0.031; closure time of successful patients, P=0.037). Conclusion. The silk patch which has transparent, elastic, adhesive, and hyper-keratinizing properties results in a more efficient closure time than the paper patch in the treatment of TTMP patients. We therefore believe that the silk patch should be recommended for the treatment of acute tympanic membrane perforation.
참고문헌 (18)
- da Lilly-Tariah OB, "Traumatic perforation of the tympanic membrane in University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria", Niger Postgrad Med J, 14(2), pp.121~124 (2007)
- Orji FT, "Determinants of spontaneous healing in traumatic perforations of the tympanic membrane", Clin Otolaryngol, 33(5), pp.420~426 (2008)
- Kristensen S, "Spontaneous healing of traumatic tympanic membrane perforations in man: a century of experience", J Laryngol Otol, 106(12), pp.1037~1050 (1992)
- Teh BM, "Tissue engineering of the tympanic membrane", Tissue Eng Part B Rev, 19(2), pp.116~132 (2013)
- Levin B, "Grafts in myringoplasty: utilizing a silk fibroin scaffold as a novel device", Expert Rev Med Devices, 6(6), pp.653~664 (2009)
- Shen Y, "Tympanic membrane repair using silk fibroin and acellular collagen scaffolds", Laryngoscope, 123(8), pp.1976~1982 (2013)
- Lee OJ, "Biodegradation behavior of silk fibroin membranes in repairing tympanic membrane perforations", J Biomed Mater Res A, 100(8), pp.2018~2026 (2012)
- Kim J, "Comparison of methods for the repair of acute tympanic membrane perforations: Silk patch vs. paper patch", Wound Repair Regen, 18(1), pp.132~138 (2010)
- Park MK, "Repair of large traumatic tympanic membrane perforation with a Steri-Strips patch", Otolaryngol Head Neck Surg, 145(4), pp.581~585 (2011)
- Saliba I, "Hyaluronic acid fat graft myringoplasty: how we do it", Clin Otolaryngol, 33(6), pp.610~614 (2008)
- Mori H, "New silk protein: modification of silk protein by gene engineering for production of biomaterials", J Biotechnol, 74(2), pp.95~103 (2000)
- Horan RL, "In vitro degradation of silk fibroin", Biomaterials, 26(17), pp.3385~3393 (2005)
- Meinel L, "The inflammatory responses to silk films in vitro and in vivo", Biomaterials, 26(2), pp.147~155 (2005)
- Mauney JR, "Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds", Biomaterials, 28(35), pp.5280~5290 (2007)
- Kim JH, "Tympanic membrane regeneration using a water-soluble chitosan patch", Tissue Eng Part A, 16(1), pp.225~232 (2010)
- Altman GH, "Silk-based biomaterials", Biomaterials, 24(3), pp.401~416 (2003)
- Levin B, "Preliminary results of the application of a silk fibroin scaffold to otology", Otolaryngol Head Neck Surg, 142(3 Suppl 1), pp.S33~S35 (2010)
- Shen Y, "Scaffolds for tympanic membrane regeneration in rats", Tissue Eng Part A, 19(5-6), pp.657~668 (2013)