본문 바로가기
KERD
논문KCI 등재

Cluster Analysis of Inhalant Allergens in South Korea: A Computational Model of Allergic Sensitization

박영선|김경래|김상헌|차경준|조석현|장대일|류승호|윤호주|김동규
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2021.02|Clinical and Experimental Otorhinolaryngology|제14권 제1호|pp. 93-99|DOI https://doi.org/10.21053/ceo.2019.01921

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

Cluster AnalysisAllergenComputational BiologySkin Test

초록

Objectives. Sensitization to specific inhalant allergens is a major risk factor for the development of atopic diseases, which impose a major socioeconomic burden and significantly diminish quality of life. However, patterns of inhalant allergic sensitization have yet to be precisely described. Therefore, to enhance the understanding of aeroallergens, we performed a cluster analysis of inhalant allergic sensitization using a computational model. Methods. Skin prick data were collected from 7,504 individuals. A positive skin prick response was defined as an allergen-to-histamine wheal ratio ≥1. To identify the clustering of inhalant allergic sensitization, we performed computational analysis using the four-parameter unified-Richards model. Results. Hierarchical cluster analysis grouped inhalant allergens into three clusters based on the Davies-Bouldin index (0.528): cluster 1 (Dermatophagoides pteronyssinus and Dermatophagoides farinae), cluster 2 (mugwort, cockroach, oak, birch, cat, and dog), and cluster 3 (Alternaria tenus, ragweed, Candida albicans, Kentucky grass, and meadow grass). Computational modeling revealed that each allergen cluster had a different trajectory over the lifespan. Cluster 1 showed a high level (>50%) of sensitization at an early age (before 19 years), followed by a sharp decrease in sensitization. Cluster 2 showed a moderate level (10%–20%) of sensitization before 29 years of age, followed by a steady decrease in sensitization. However, cluster 3 revealed a low level (<10%) of sensitization at all ages. Conclusion. Computational modeling suggests that allergic sensitization consists of three clusters with distinct patterns at different ages. The results of this study will be helpful to allergists in managing patients with atopic diseases.

Abstract

Objectives. Sensitization to specific inhalant allergens is a major risk factor for the development of atopic diseases, which impose a major socioeconomic burden and significantly diminish quality of life. However, patterns of inhalant allergic sensitization have yet to be precisely described. Therefore, to enhance the understanding of aeroallergens, we performed a cluster analysis of inhalant allergic sensitization using a computational model. Methods. Skin prick data were collected from 7,504 individuals. A positive skin prick response was defined as an allergen-to-histamine wheal ratio ≥1. To identify the clustering of inhalant allergic sensitization, we performed computational analysis using the four-parameter unified-Richards model. Results. Hierarchical cluster analysis grouped inhalant allergens into three clusters based on the Davies-Bouldin index (0.528): cluster 1 (Dermatophagoides pteronyssinus and Dermatophagoides farinae), cluster 2 (mugwort, cockroach, oak, birch, cat, and dog), and cluster 3 (Alternaria tenus, ragweed, Candida albicans, Kentucky grass, and meadow grass). Computational modeling revealed that each allergen cluster had a different trajectory over the lifespan. Cluster 1 showed a high level (>50%) of sensitization at an early age (before 19 years), followed by a sharp decrease in sensitization. Cluster 2 showed a moderate level (10%–20%) of sensitization before 29 years of age, followed by a steady decrease in sensitization. However, cluster 3 revealed a low level (<10%) of sensitization at all ages. Conclusion. Computational modeling suggests that allergic sensitization consists of three clusters with distinct patterns at different ages. The results of this study will be helpful to allergists in managing patients with atopic diseases.

참고문헌 (38)

  1. 박혜정, "Changes in Allergen Sensitization Over The Last 30 Years in Korea Respiratory Allergic Patients: A Single-Center", Allergy, Asthma & Immunology Research, 6(5), pp.434~443 (2014), 대한천식알레르기학회
  2. 강민규, "Patterns of Inhalant Allergen Sensitization and Geographical Variation in Korean Adults: A Multicenter Retrospective Study", Allergy, Asthma & Immunology Research, 9(6), pp.499~508 (2017), 대한천식알레르기학회
  3. Shin JH, "How does the pattern of aeroallergen sensitization change over time across all ages?", Int Forum Allergy Rhinol, 7(7), pp.652~659 (2017)
  4. Yong SB, "Different profiles of allergen sensitization in different ages and geographic areas in Changhua, Taiwan", J Microbiol Immunol Infect, 46(4), pp.295~301 (2013)
  5. Mehulic M, "Changing pattern of sensitization in Croatia to aeroallergens in adult population referring to allergy clinic during a period of 15 years", Coll Antropol, 35(2), pp.529~536 (2011)
  6. Veskitkul J, "The development of allergic rhinitis in children previously diagnosed as nonallergic rhinitis", Am J Rhinol Allergy, 27(1), pp.43~47 (2013)
  7. Linneberg A, "Increasing prevalence of specific IgE to aeroallergens in an adult population: two cross-sectional surveys 8 years apart: the Copenhagen Allergy Study", J Allergy Clin Immunol, 106(2), pp.247~252 (2000)
  8. Demain JG, "Climate change and the impact on respiratory and allergic disease: 2018", Curr Allergy Asthma Rep, 18(4), pp.22~ (2018)
  9. D’Amato G, "Climate change and air pollution: effects on pollen allergy and other allergic respiratory diseases", Allergo J Int, 23(1), pp.17~23 (2014)
  10. D’Amato G, "Climate change, air pollution, and allergic respiratory diseases: an update", Curr Opin Allergy Clin Immunol, 16(5), pp.434~440 (2016)
  11. Jerrett M, "Long-term ozone exposure and mortality", N Engl J Med, 360(11), pp.1085~1095 (2009)
  12. McGeachie MJ, "Patterns of growth and decline in lung function in persistent childhood asthma", N Engl J Med, 374(19), pp.1842~1852 (2016)
  13. McConnell R, "Traffic, susceptibility, and childhood asthma", Environ Health Perspect, 114(5), pp.766~772 (2006)
  14. Jerrett M, "A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada", Environ Health Perspect, 117(5), pp.772~777 (2009)
  15. Burbach GJ, "GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe", Allergy, 64(10), pp.1507~1515 (2009)
  16. Schmitz R, "Patterns of sensitization to inhalant and food allergens: findings from the German Health Interview and Examination Survey for Children and Adolescents", Int Arch Allergy Immunol, 162(3), pp.263~270 (2013)
  17. Salo PM, "Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES)2005-2006", J Allergy Clin Immunol, 134(2), pp.350~359 (2006)
  18. Voloshin S, "Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation)", PLoS One, 13(3), pp.e0194775~ (2018)
  19. Tjorve KMC, "The use of Gompertz models in growth analyses, and new Gompertz-model approach: an addition to the Unified-Richards family", PLoS One, 12(6), pp.e0178691~ (2017)
  20. Tjorve E, "A unified approach to the Richards-model family for use in growth analyses: why we need only two model forms", J Theor Biol, 267(3), pp.417~425 (2010)
  21. Walker S, "Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study", J Allergy Clin Immunol, 120(2), pp.381~387 (2007)
  22. 이동준, "The Impact of Allergic Rhinitis on Symptom Improvement in Pediatric Patients After Adenotonsillectomy", Clinical and Experimental Otorhinolaryngology, 11(1), pp.52~57 (2018), 대한이비인후과학회[DOI]
  23. 김민재, "Effect of Adenotonsillectomy on Attention in Korean Children With Sleep-Disordered Breathing", Clinical and Experimental Otorhinolaryngology, 11(3), pp.199~204 (2018), 대한이비인후과학회[DOI]
  24. Zar HJ, "The changing prevalence of asthma, allergic rhinitis and atopic eczema in African adolescents from 1995 to 2002", Pediatr Allergy Immunol, 18(7), pp.560~565 (2007)
  25. Maziak W, "Are asthma and allergies in children and adolescents increasing? Results from ISAAC phase I and phase III surveys in Munster, Germany", Allergy, 58(7), pp.572~579 (2003)
  26. Lee SL, "Increasing prevalence of allergic rhinitis but not asthma among children in Hong Kong from 1995 to 2001(Phase 3 International Study of Asthma and Allergies in Childhood)", Pediatr Allergy Immunol, 15(1), pp.72~78 (2004)
  27. Pearce N, "Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)", Thorax, 62(9), pp.758~766 (2007)
  28. Bjorksten B, "Worldwide time trends for symptoms of rhinitis and conjunctivitis: phase III of the International Study of Asthma and Allergies in Childhood", Pediatr Allergy Immunol, 19(2), pp.110~124 (2008)
  29. Asher MI, "Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys", Lancet, 368(9537), pp.733~743 (2006)
  30. Kim SY, "Increased prevalence of self-reported asthma among Korean adults: an analysis of KNHANES I and IV data", Lung, 191(3), pp.281~288 (2013)
  31. 박윤형, "A 9-year Trend in the Prevalence of Allergic Disease Based on National Health Insurance Data", 예방의학회지, 48(6), pp.301~309 (2015), 대한예방의학회
  32. 김지현, "Sensitization to Aeroallergens in Korean Children: A Populationbased Study in 2010", Journal of Korean Medical Science, 26(9), pp.1165~1172 (2011), 대한의학회
  33. Luoma R, "Development of asthma, allergic rhinitis and atopic dermatitis by the age of five years: a prospective study of 543 newborns", Allergy, 38(5), pp.339~346 (1983)
  34. Olsson P, "Prevalence of self-reported allergic and non-allergic rhinitis symptoms in Stockholm: relation to age, gender, olfactory sense and smoking", Acta Otolaryngol, 123(1), pp.75~80 (2003)
  35. Shen CY, "The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based birth cohort study", Allergy Asthma Proc, 34(1), pp.78~83 (2013)
  36. Cazzoletti L, "The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study", Allergy Asthma Clin Immunol, 11, pp.36~ (2015)
  37. Yu HT, "T cell immunosenescence, hypertension, and arterial stiffness", Epidemiol Health, 36, pp.e2014005~ (2014)
  38. Maue AC, "T-cell immunosenescence: lessons learned from mouse models of aging", Trends Immunol, 30(7), pp.301~305 (2009)

관련 논문AI추천

Aeroallergen Sensitization Status in South Korea From 2018 to 2021김수현, 김인태, 김진국, 민도식, 조재훈대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2022 · 제15권 제3호천식 및 알레르기비염으로 진단된 소아, 청소년 및 성인에서의 흡입 알레르겐에 대한 감작률 비교김희규, 이나겸, 최길순대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2021 · 제9권 제3호Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years곽지희, 김덕수, 김예지, 설인숙, 심재원, 심정연, 양아람, 이미연, 정혜림연세대학교의과대학 · Yonsei Medical Journal2020 · 제61권 제9호최근 40년간 부산지역 호흡기 알레르기 환자에서 흡입 알레르기에 대한 감작률 변화 조사권재환, 김주연, 조중환, 최길순, 황현정대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2024 · 제67권 제4호국내 성인 알레르겐 감작률과 Geographic Information System 기반 공간분석을 활용한 지역별 감작률 연구강성윤, 권재우, 김형년, 임정훈, 정성근, 정재원대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2023 · 제11권 제3호단일기관 소아 알레르기질환 환자에서 최근 흡입항원 감작 패턴의 변화: 단일기관 연구김정민, 김효빈, 이수진대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2019 · 제7권 제4호

이 간행물의 다른 논문 (21건)

Do Women Have Better Hearing Than Men?박용호pp. 1-2The Use of MicroRNAs for the Early Diagnosis of Dementia in Patients Affected by Hearing Loss박무균, 여차동pp. 3-4Music and Lyrics: Musical Training for Aural Rehabilitation김예리, 강우석pp. 5-6The Need to Consider Vestibular Function in Cochlear Implantation나윤찬pp. 7-8Can We Kill Two Birds With One Stone? Achieving Function and Aesthetics by Extracorporeal Septoplasty장용주pp. 9-10
원문 보기