Age Differences in Pet Sensitization by Pet Ownership
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives. The association between pet sensitization and pet ownership remains unclear. Therefore, we aimed to elucidate the association between pet sensitization and pet ownership by age. Methods. We retrospectively reviewed 2,883 patients who visited our allergy clinic for nasal symptoms from January 2003 to December 2014, of whom 1,957 patients with data on skin-prick tests and questionnaire responses were included and divided into adults (age >19 years) and children (age ≤19 years). The association between pet sensitization and pet ownership was evaluated in both groups. Results. Among children, dog and cat sensitization showed no associations with dog and cat ownership, respectively. However, among adults, dog sensitization was significantly associated with dog ownership (odds ratio [OR], 3.283; P<0.001), and cat sensitization with cat ownership (OR, 13.732; P<0.001). After adjustment for age, sex, familial history of allergy, sinusitis, diabetes mellitus, other pet ownership, and non-pet sensitization, significant associations remained between dog sensitization and dog ownership (adjusted OR [aOR], 3.881; P<0.001), and between cat sensitization and cat ownership (aOR, 10.804; P<0.001) among adults. Dog ownership did not show any association with allergic rhinitis, asthma, or atopic dermatitis, whereas atopic dermatitis had a significant association with cat ownership in adults (aOR, 4.840; P<0.001). Conclusion. Pet ownership in adulthood increased the risk of pet sensitization. However, pet ownership was not associated with the prevalence of atopic disorders, regardless of age, except for atopic dermatitis and cat ownership in adults.
Abstract
Objectives. The association between pet sensitization and pet ownership remains unclear. Therefore, we aimed to elucidate the association between pet sensitization and pet ownership by age. Methods. We retrospectively reviewed 2,883 patients who visited our allergy clinic for nasal symptoms from January 2003 to December 2014, of whom 1,957 patients with data on skin-prick tests and questionnaire responses were included and divided into adults (age >19 years) and children (age ≤19 years). The association between pet sensitization and pet ownership was evaluated in both groups. Results. Among children, dog and cat sensitization showed no associations with dog and cat ownership, respectively. However, among adults, dog sensitization was significantly associated with dog ownership (odds ratio [OR], 3.283; P<0.001), and cat sensitization with cat ownership (OR, 13.732; P<0.001). After adjustment for age, sex, familial history of allergy, sinusitis, diabetes mellitus, other pet ownership, and non-pet sensitization, significant associations remained between dog sensitization and dog ownership (adjusted OR [aOR], 3.881; P<0.001), and between cat sensitization and cat ownership (aOR, 10.804; P<0.001) among adults. Dog ownership did not show any association with allergic rhinitis, asthma, or atopic dermatitis, whereas atopic dermatitis had a significant association with cat ownership in adults (aOR, 4.840; P<0.001). Conclusion. Pet ownership in adulthood increased the risk of pet sensitization. However, pet ownership was not associated with the prevalence of atopic disorders, regardless of age, except for atopic dermatitis and cat ownership in adults.
참고문헌 (35)
- Bousquet J, "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)", Allergy, 63(Suppl 86), pp.8~160 (2008)
- Vinke JG, "Differences in nasal cellular infiltrates between allergic children and age-matched controls", Eur Respir J, 13(4), pp.797~803 (1999)
- Perzanowski MS, "Effect of cat and dog ownership on sensitization and development of asthma among preteenage children", Am J Respir Crit Care Med, 166(5), pp.696~702 (2002)
- Craig TJ, "Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma", J Allergy Clin Immunol, 121(3), pp.671~677 (2008)
- Kim DH, "Prevalence and allergen of allergic rhinitis in Korean children", Am J Rhinol Allergy, 30(3), pp.72~78 (2016)
- Salo PM, "Does exposure to cats and dogs decrease the risk of allergic sensitization and disease?", J Allergy Clin Immunol, 124(4), pp.751~752 (2009)
- Kerkhof M, "Effects of pets on asthma development up to 8 years of age: the PIAMA study", Allergy, 64(8), pp.1202~1208 (2009)
- Almqvist C, "Heredity, pet ownership, and confounding control in a population-based birth cohort", J Allergy Clin Immunol, 111(4), pp.800~806 (2003)
- Bornehag CG, "Pet-keeping in early childhood and airway, nose and skin symptoms later in life", Allergy, 58(9), pp.939~944 (2003)
- Arshad SH, "Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study", Pediatrics, 108(2), pp.E33~ (2001)
- Lindfors A, "Influence of interaction of environmental risk factors and sensitization in young asthmatic children", J Allergy Clin Immunol, 104(4 Pt 1), pp.755~762 (1999)
- Munir AK, "Exposure to indoor allergens in early infancy and sensitization", J Allergy Clin Immunol, 100(2), pp.177~181 (1997)
- Ownby DR, "Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization?", Curr Opin Allergy Clin Immunol, 3(6), pp.517~522 (2003)
- Hesselmar B, "Does early exposure to cat or dog protect against later allergy development?", Clin Exp Allergy, 29(5), pp.611~617 (1999)
- Ritz BR, "Allergic sensitization owing to ‘second-hand’ cat exposure in schools", Allergy, 57(4), pp.357~361 (2002)
- 박용범, "Association Between Pet Ownership and the Sensitization to Pet Allergens in Adults With Various Allergic Diseases", Allergy, Asthma & Immunology Research, 5(5), pp.295~300 (2013), 대한천식알레르기학회
- Roost HP, "Role of current and childhood exposure to cat and atopic sensitization. European Community Respiratory Health Survey", J Allergy Clin Immunol, 104(5), pp.941~947 (1999)
- Arbes SJ Jr, "Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: results from the National Survey of Lead and Allergens in Housing", J Allergy Clin Immunol, 114(1), pp.111~117 (2004)
- Heinrich J, "Cat allergen level: its determinants and relationship to specific IgE to cat across European centers", J Allergy Clin Immunol, 118(3), pp.674~681 (2006)
- Zheng T, "Childhood asthma in Beijing, China: a population-based case-control study", Am J Epidemiol, 156(10), pp.977~983 (2002)
- Custovic A, "Decreased prevalence of sensitization to cats with high exposure to cat allergen", J Allergy Clin Immunol, 108(4), pp.537~539 (2001)
- Custovic A, "Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults", J Allergy Clin Immunol, 111(2), pp.402~407 (2003)
- Oryszczyn MP, "Allergy markers in adults in relation to the timing of pet exposure: the EGEA study", Allergy, 58(11), pp.1136~1143 (2003)
- Ownby DR, "Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age", JAMA, 288(8), pp.963~972 (2002)
- Linneberg A, "Pets in the home and the development of pet allergy in adulthood. The Copenhagen Allergy Study", Allergy, 58(1), pp.21~26 (2003)
- Jaakkola JJ, "Pets, parental atopy, and asthma in adults", J Allergy Clin Immunol, 109(5), pp.784~788 (2002)
- Platts-Mills TA, "Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals", Springer Semin Immunopathol, 25(3-4), pp.271~279 (2004)
- Apelberg BJ, "Systematic review: exposure to pets and risk of asthma and asthma-like symptoms", J Allergy Clin Immunol, 107(3), pp.455~460 (2001)
- Langan SM, "The role of furry pets in eczema: a systematic review", Arch Dermatol, 143(12), pp.1570~1577 (2007)
- Takkouche B, "Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis", Allergy, 63(7), pp.857~864 (2008)
- Pelucchi C, "Pet exposure and risk of atopic dermatitis at the pediatric age: a meta-analysis of birth cohort studies", J Allergy Clin Immunol, 132(3), pp.616~622 (2013)
- Kaiser L, "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family", J Biol Chem, 278(39), pp.37730~37735 (2003)
- Virtanen T, "Lipocalin allergens", Allergy, 56(Suppl 67), pp.48~51 (2001)
- Mims JW, "Asthma: definitions and pathophysiology", Int Forum Allergy Rhinol, 5(Suppl 1), pp.S2~S6 (2015)
- Eichenfield LF, "Guidelines of care for the management of atopic dermatitis: section 1: diagnosis and assessment of atopic dermatitis", J Am Acad Dermatol, 70(2), pp.338~351 (2014)
