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경련지속상태 후 뇌사에 이른 환아의 뇌척수액에서 발견된 human herpesvirus-6 (HHV-6)

Detection of Human Herpesvirus-6 (HHV-6) in Cerebrospinal Fluid of a Patient with Fatal Status Epilepticus

송정숙|강은경|조성민
대한소아신경학회 (the Korean Child Neurology Society)|2012.09|대한소아신경학회지 (Journal of the korean child neurology society)|제20권 제3호|pp. 196-200

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참고문헌

주제분류신경과학

초록

저자들은 14개월 된 여아가 발열을 동반한 경련지속상태로 내원하여 의식 회복 없이 뇌사 상태로 진행하여 사망한 14개월 여아에서 뇌척수액 HHV-6 DNA 중합효소연쇄반응 양성이 확인된 1례를 경험하였기에 보고하는 바이며, 뇌염 의심 환자에서 뇌척수액 검사 시 HHV-6 검사가 필요할 것으로 생각한다.

Abstract

Human herpesvirus-6 (HHV-6) often causes mild illnesses, but is rarely associated with encephalitis or other fatal neurological conditions. We report a girl who died of a intractable status epilepticus from HHV-6. A 14-month-old girl presented with focal motor seizures in right extremities evolving to generalized convulsive status epilepticus. She had a history of mild diarrhea for 4 days and high fever for 2 days. Although she was treated with lorazepam, phenytoin, phenobarbital, and continuous midazolam infusion, generalized seizures continued for 3 hours after arrival. She became seizure free, but remained unconscious and ended up to death at the 44 days of hospitalization. The CSF HHV-6 DNA PCR turned out to be positive.

참고문헌 (20)

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