A Case of Primary Brain Calcification Presenting with Gait Disturbance in an Adolescent
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Primary brain calcification (PBC) is a neurodegenerative disorder characterized by idiopathic calcification of the basal ganglia that is rare in children and adolescents. This report describes a 16-year-old boy who complained of progressive walking difficulty and gait disturbance for 3 years. Physical examination showed positive reaction to ankle clonus and increased deep tendon reflex on both legs. There was no family history of metabolic disorder or neurologic diseases. Brain computed tomography (CT) and brain magnetic resonance imaging (MRI) revealed extensive calcifications in the bilateral cerebral white matter, basal ganglia, thalamus and dentate nucleus of the cerebellum. Laboratory and genetic studies showed nothing of note. This case report describes an unusual case of sporadic primary brain calcification, diagnosed in adolescence by the presence of gait difficulty and mild mental retardation and its review.
Abstract
Primary brain calcification (PBC) is a neurodegenerative disorder characterized by idiopathic calcification of the basal ganglia that is rare in children and adolescents. This report describes a 16-year-old boy who complained of progressive walking difficulty and gait disturbance for 3 years. Physical examination showed positive reaction to ankle clonus and increased deep tendon reflex on both legs. There was no family history of metabolic disorder or neurologic diseases. Brain computed tomography (CT) and brain magnetic resonance imaging (MRI) revealed extensive calcifications in the bilateral cerebral white matter, basal ganglia, thalamus and dentate nucleus of the cerebellum. Laboratory and genetic studies showed nothing of note. This case report describes an unusual case of sporadic primary brain calcification, diagnosed in adolescence by the presence of gait difficulty and mild mental retardation and its review.
참고문헌 (14)
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