Early Infantile Meningitis Trends in Full-term Infants: A Korean Single-center Study, 2008-2013
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Purpose: The characteristics of early infantile meningitis in full-term and previously healthy infants may differ from those in preterm or previously ill infants. However, full-term and previously healthy infant data remain scarce, and the recent trends are not well known. Method: Full-term and previously healthy infants (<3 months old) diagnosed with meningitis in our hospital between January 2008 and December 2013 were enrolled. We retrospectively reviewed their clinical and laboratory data. Results: A total of 162 full-term and early infants with meningitis (male, 55.6%;mean age, 45 days) were enrolled. Among them, 122 patients (75.3%) were diagnosed with viral meningitis (63 enterovirus-proven and 59 viral-suspected), and 40 patients (24.7%) were diagnosed with bacterial meningitis (18 bacteria-proven and 22 bacterial-suspected). The proportion of early infantile meningitis among all infants admitted (<3 months of age) increased significantly from 1.6% to 3.1%, and viral meningitis increased from 1.1% to 2.3% (P<0.01). Early infantile meningitis increased significantly at each 2-year interval. The seasonal viral meningitis peak shifted from July to June after 2012. Group B Streptococcus was the most common bacterial pathogen (88.9%) and usually caused late-onset meningitis (14 of 16). Coxsackie B viruses were most commonly isolated (59.3%) from the 54 patients with viral meningitis using available genotype data. Conclusion: Early infantile meningitis in previously healthy full-term infants (<3 months old) increased significantly between 2008 and 2013, and most cases were viral meningitis. The seasonal viral meningitis peak shifted from July to June after 2012.
Abstract
Purpose: The characteristics of early infantile meningitis in full-term and previously healthy infants may differ from those in preterm or previously ill infants. However, full-term and previously healthy infant data remain scarce, and the recent trends are not well known. Method: Full-term and previously healthy infants (<3 months old) diagnosed with meningitis in our hospital between January 2008 and December 2013 were enrolled. We retrospectively reviewed their clinical and laboratory data. Results: A total of 162 full-term and early infants with meningitis (male, 55.6%;mean age, 45 days) were enrolled. Among them, 122 patients (75.3%) were diagnosed with viral meningitis (63 enterovirus-proven and 59 viral-suspected), and 40 patients (24.7%) were diagnosed with bacterial meningitis (18 bacteria-proven and 22 bacterial-suspected). The proportion of early infantile meningitis among all infants admitted (<3 months of age) increased significantly from 1.6% to 3.1%, and viral meningitis increased from 1.1% to 2.3% (P<0.01). Early infantile meningitis increased significantly at each 2-year interval. The seasonal viral meningitis peak shifted from July to June after 2012. Group B Streptococcus was the most common bacterial pathogen (88.9%) and usually caused late-onset meningitis (14 of 16). Coxsackie B viruses were most commonly isolated (59.3%) from the 54 patients with viral meningitis using available genotype data. Conclusion: Early infantile meningitis in previously healthy full-term infants (<3 months old) increased significantly between 2008 and 2013, and most cases were viral meningitis. The seasonal viral meningitis peak shifted from July to June after 2012.
참고문헌 (33)
- Baraff LJ, "Management of fever without source in infants and children", Ann Emerg Med, 36, pp.602~614 (2000)
- Okike IO, "Incidence, etiology, and outcome of bacterial meningitis in infants aged <90 days in the United Kingdom and Republic of Ireland: prospective, enhanced, national population-Based surveillance", Clin Infect Dis, 59, pp.e150~e157 (2014)
- Nel E, "Neonatal meningitis : mortality, cerebrospinal fluid, and microbiological findings", J Trop Pediatr, 46, pp.237~239 (2000)
- Furyk JS, "Systematic review : neonatal meningitis in the developing world", Trop Med Int Health, 16, pp.672~679 (2011)
- Lee BE, "Aseptic meningitis", Curr Opin Infect Dis, 20, pp.272~277 (2007)
- Srinivasan L, "Lumbar puncture in the neonate : challenges in decision making and interpretation", Semin Perinatol, 36, pp.445~453 (2012)
- Byington CL, "Normative cerebrospinal fluid profiles in febrile infants", J Pediatr, 158, pp.130~134 (2011)
- Bonadio WA, "Reference values of normal cerebrospinal fluid composition in infants ages 0 to 8 weeks", Pediatr Infect Dis J, 11, pp.589~591 (1992)
- Kestenbaum LA, "Defining cerebrospinal fluid white blood cell count reference values in neonates and young infants", Pediatrics, 125, pp.257~264 (2010)
- Garges HP, "Neonatal meningitis : what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?", Pediatrics, 117, pp.1094~1100 (2006)
- Abzug MJ, "Presentation, diagnosis, and management of enterovirus infections in neonates", Paediatr Drugs, 6, pp.1~10 (2004)
- Khetsuriani N, "Neonatal enterovirus infections reported to the national enterovirus surveillance system in the United States, 1983-2003", Pediatr Infect Dis J, 25, pp.889~893 (2006)
- Hyeon JY, "Accuracy of diagnostic methods and surveillance sensitivity for human enterovirus, South Korea, 1999-2011", Emerg Infect Dis, 19, pp.1268~1275 (2013)
- Olaciregui I, "Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin", Arch Dis Child, 94, pp.501~505 (2009)
- 송향순, "열이 있는 3개월 이하의 영아에서 수막염의 예측에 대한 연구", Pediatric Infection and Vaccine, 16(1), pp.40~46 (2009), 대한소아감염학회
- Srinivasan L, "Traumatic lumbar punctures in infants hospitalized in the neonatal intensive care unit", Pediatr Infect Dis J, 32, pp.1150~1152 (2013)
- 신소연, "Evaluation of the Seeplex® Meningitis ACE Detection Kit for the Detection of 12 Common Bacterial and Viral Pathogens of Acute Meningitis", Annals of Laboratory Medicine, 32(1), pp.44~49 (2012), 대한진단검사의학회
- Tebruegge M, "Enterovirus infections in neonates", Semin Fetal Neonatal Med, 14, pp.222~227 (2009)
- 정지인, "B군 연구균에 의해 발생한 신생아 수막염: 2001-2011년", Perinatology, 24(3), pp.142~147 (2013), 대한주산의학회
- 박준석, "신생아 및 3개월 이하의 영아의 세균수막염의 임상적 양상과 치료결과", 대한소아신경학회지, 18(2), pp.237~243 (2010), 대한소아신경학회
- Uh Y, "Colonization rates and serotypes of group B streptococci isolated from pregnant women in a Korean tertiary hospital", Eur J Clin Microbiol Infect Dis, 16, pp.753~756 (1997)
- Davies HD, "Two-year survey of Alberta laboratories processing of antenatal group B streptococcal(GBS)screening specimens : implications for GBS screening programs", Diagn Microbiol Infect Dis, 35, pp.169~176 (1999)
- Hong JS, "Genital group B Streptococcus carrier rate and serotype distribution in Korean pregnant women : implications for group B streptococcal disease in Korean neonates", J Perinat Med, 38, pp.373~377 (2010)
- Seiden JA, "Lack of cerebrospinal fluid pleocytosis in young infants with enterovirus infections of the central nervous system", Pediatr Emerg Care, 26, pp.77~81 (2010)
- Smith PB, "Meningitis in preterm neonates : importance of cerebrospinal fluid parameters", Am J Perinatol, 25, pp.421~426 (2008)
- Rotbart HA, "Clinical significance of enteroviruses in serious summer febrile illnesses of children", Pediatr Infect Dis J, 18, pp.869~874 (1999)
- Kupila L, "Diagnosis of enteroviral meningitis by use of polymerase chain reaction of cerebrospinal fluid, stool, and serum specimens", Clin Infect Dis, 40, pp.982~987 (2005)
- Abzug MJ, "Profile of enterovirus disease in the first two weeks of life", Pediatr Infect Dis J, 12, pp.820~824 (1993)
- Bryant PA, "Neonatal coxsackie B virus infection-a treatable disease?", Eur J Pediatr, 163, pp.223~228 (2004)
- Kaplan MH, "Group B coxsackievirus infections in infants younger than three months of age : a serious childhood illness", Rev Infect Dis, 5, pp.1019~1032 (1983)
- Wikswo ME, "Increased activity of Coxsackievirus B1 strains associated with severe disease among young infants in the United States, 2007-2008", Clin Infect Dis, 49, pp.e44~e51 (2009)
- Lin TY, "Neonatal enterovirus infections : emphasis on risk factors of severe and fatal infections", Pediatr Infect Dis J, 22, pp.889~894 (2003)
- Wang SM, "Update of enterovirus 71 infection : epidemiology, pathogenesis and vaccine", Expert Rev Anti Infect Ther, 12, pp.447~456 (2014)