Hashimoto’s Encephalopathy: Two Pediatric Cases
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Hashimoto’s encephalopathy (HE) is an uncommon syndrome characterized by encephalopathy associated with elevated levels of anti-thyroid antibodies including anti-thyroperoxidase (TPO) and/or anti-thyroglobulin (TG) antibodies. We report two pediatric cases that presented with acute cognitive deteriorations. The first patient (an 11-year-old girl) had Hashimoto’s thyroiditis with normal thyroid function and was admitted due to altered mentality and headache. Etiological examinations ruled out other causes of encephalopathy except for the elevated levels of anti-TPO and anti-TG antibodies. The second patient was a previously healthy 15-year-old girl who presented with sudden onset confusion. An increased level of anti-thyroid antibodies was identified while other physical and laboratory examinations were unremarkable. The neuropsychiatric symptoms for both patients improved significantly following treatment with high-dose methylprednisolone. HE is often misdiagnosed due to its nonspecific symptoms; however, it is usually reversible with appropriate therapy. Therefore, it is important to consider HE in children with unexplained encephalopathy.
Abstract
Hashimoto’s encephalopathy (HE) is an uncommon syndrome characterized by encephalopathy associated with elevated levels of anti-thyroid antibodies including anti-thyroperoxidase (TPO) and/or anti-thyroglobulin (TG) antibodies. We report two pediatric cases that presented with acute cognitive deteriorations. The first patient (an 11-year-old girl) had Hashimoto’s thyroiditis with normal thyroid function and was admitted due to altered mentality and headache. Etiological examinations ruled out other causes of encephalopathy except for the elevated levels of anti-TPO and anti-TG antibodies. The second patient was a previously healthy 15-year-old girl who presented with sudden onset confusion. An increased level of anti-thyroid antibodies was identified while other physical and laboratory examinations were unremarkable. The neuropsychiatric symptoms for both patients improved significantly following treatment with high-dose methylprednisolone. HE is often misdiagnosed due to its nonspecific symptoms; however, it is usually reversible with appropriate therapy. Therefore, it is important to consider HE in children with unexplained encephalopathy.
참고문헌 (15)
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