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논문KCI 등재

항염증 성분이 증가된 차조기 신품종 ‘안티스페릴

A New Perilla frutescens var. crispa ‘Antisperill’ with Anti-Inflammatory Properties

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참고문헌

키워드

주제분류농학

초록

Perilla frutescens var. crispa has a unique aroma, purple leaves, and is similar in appearance to perilla. It is an annual herbaceousplant belonging to the Lamiaceae family, in addition it is known to have various pharmacological effects. In 1995, 200 Gy of gamma rayswere irradiated to ‘Chookyoupjaso’ landrace seeds, and 6 candidate mutant lines with optimal agronomic traits were selected in the first round. Of them, one of mutant lines which had an increased isoegomaketone content and an anti-inflammatory component, were selected and cultivated. Subsequently, the variety protection right was registered in 2022 under the varietal name 'Antisperilll'. The main characteristics of 'Antisperilll'were that the leaf color changed from purple to green, the seed color from brown to gray, and the 1,000 seed weight was 3.29 g, whichwas approximately 1.7 times heavier than the original wild type (1.94 g). The isoegomaketone content, which exhibits anti-inflammatory effects,was increased and is expected to be used as a new health food and raw material to improve inflammatory diseases (Registration No. 8812).

Abstract

Perilla frutescens var. crispa has a unique aroma, purple leaves, and is similar in appearance to perilla. It is an annual herbaceousplant belonging to the Lamiaceae family, in addition it is known to have various pharmacological effects. In 1995, 200 Gy of gamma rayswere irradiated to ‘Chookyoupjaso’ landrace seeds, and 6 candidate mutant lines with optimal agronomic traits were selected in the first round. Of them, one of mutant lines which had an increased isoegomaketone content and an anti-inflammatory component, were selected and cultivated. Subsequently, the variety protection right was registered in 2022 under the varietal name 'Antisperilll'. The main characteristics of 'Antisperilll'were that the leaf color changed from purple to green, the seed color from brown to gray, and the 1,000 seed weight was 3.29 g, whichwas approximately 1.7 times heavier than the original wild type (1.94 g). The isoegomaketone content, which exhibits anti-inflammatory effects,was increased and is expected to be used as a new health food and raw material to improve inflammatory diseases (Registration No. 8812).

참고문헌 (11)

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  2. Brochers AT, "Complementary medicine : a review of immunomodulatory effects of Chinese herbal medicines", Am J Clin Nutr, 66, pp.1303~1312 (1997)
  3. Chung BH, "Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells", Cancer Lett, 236, pp.222~228 (2006)
  4. Jin CH, "Isoegomaketone inhibits lipopolysaccharideinduced nitric oxide production in RAW264. 7 macrophages through the heme oxygenase-1 induction and inhibition of the interferon-b-STAT-1 pathway", J Agric Food Chem, 58, pp.860~867 (2010)
  5. 조일주, "마우스 대식세포주인 RAW 264.7 세포에서 蜈蚣의 항염증 효과", 대한본초학회지, 26(3), pp.23~29 (2011), 대한본초학회
  6. Kim YR, "Isoegomaketone from Perilla frutescens (L.) Britt stimulates MAPK", ERK pathway in human keratinocyte to promote skin wound healing, 2021, ~
  7. Park SM, "Inhibitory effect of Mori Folium ethanol extract on proinflammatory mediator in lipopolysaccharide-activated RAW 264. 7 cells", Korean J Herbol, 27, pp.31~38 (2012)
  8. Yong Dae Park, "Phytochemical Profiles and in vitro Anti-inflammatory Properties of Perilla frutescens cv. Chookyoupjaso Mutants Induced by Mutagenesis with γ-Ray", Food Science and Biotechnology, 19(2), pp.305~311 (2010), 한국식품과학회
  9. Schmith VD, "Effects of inflammation on pharmacokinetics", pharmacodynamics : Increasing recognition of its contribution to variability in response, 2008, pp.83, 809~811
  10. 정지연, "연자육의 페놀성 성분 및 Tyrosinase 저해 활성", 생약학회지, 46(1), pp.1~5 (2015), 한국생약학회
  11. Ueda H, "Inhibition of tumor necrosis factor-α production by orally administering a perilla leaf extract", Biosci Biotechnol Biochem, 61, pp.1292~1295 (1997)

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