Retinal Angiomatous Proliferation and Intravitreal Bevacizumab Injection
2
조회
0
다운로드
3
인용
0
참고문헌
초록
Abstract
Purpose: To evaluate the short-term efficacy and safety of intravitreal bevacizumab injection (IVBI) in patients with retinal angiomatous proliferation (RAP). Methods: Seven eyes of 5 patients with RAP were included in this study. All of the eyes evidenced stage 2 RAP lesions, except for one eye with a stage 3 lesion. IVBI (1.25 mg/0.05 cc) were conducted at 4 or 6-week intervals. Complete ocular examinations, angiographic results and optical coherence tomographic findings before and after the IVBI were analyzed at baseline and upon the follow-up visits. Results: Seven eyes were studied in 5 patients who had undergone IVBI. Partial (3 eyes) or complete (4 eyes) regression of RAP was noted after IVBI in all of the studied eyes. Visual acuity improved in 5 of the eyes, and was stable in 2 of the eyes. One eye evidenced severe intraocular inflammation after IVBI and a subsequent development of new RAP, which was controlled with vitrectomy and repeat IVBI. Conclusions: This treatment was effective over 6 months, stabilizing or improving visual acuity and reducing angiographic leakage. These short-term results suggest that IVBI may constitute a promising therapeutic option, particularly in the early stages of RAP.
참고문헌 (13)
- Yannuzzi LA, "Retinal angiomatous proliferation in age-related macular degeneration", 21, pp.416~434 (2001)
- Gass JD, "Focal inner retinal hemorrhages in patients with drusen: an early sign of occult choroidal neovascularization and chorioretinal anastomosis", 23, pp.741~751 (2003)
- Hartnett ME, "Deep retinal vascular anomalous complexes in advanced age-related macular degeneration", 103, pp.2042~2053 (1996)
- Kuhn D, "Imaging of chorioretinal anastomoses in vascularized retinal pigment epithelium detachments", 113, pp.1392~1398 (1995)
- Blodi CF, "Folk JC. Direct and feeder vessel photocoagulation of retinal angiomas with dye yellow laser. Ophthalmology 1990", pp.791~5
- Borrillo JL, "Surgical ablation of retinal angiomatous proliferation", 121, pp.558~561 (2003)
- Boscia F, "Combined surgical ablation and intravitreal triamcinolone acetonide for retinal angiomatous proliferation", 15, pp.513~516 (2005)
- Boscia F, "Photodynamic therapy with verteporfin for retinal angiomatous proliferation", 224, pp.1224~1232 (2006)
- Bottoni F, "Treatment of retinal angiomatous proliferation in age-related macular degeneration: a series of 104 cases of retinal angiomatous proliferation", 123, pp.1644~1650 (2005)
- Kuroiwa S, "Rapidly progressive scar formation after transpupillary thermotherapy in retinal angiomatous proliferation", 23, pp.417~420 (2003)
- Okamoto N, "Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization", 151, pp.281~291 (1997)
- Lopez PF, "Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes", 37, pp.855~868 (1996)
- Wells JA, "Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation", 80, pp.363~366 (1996)