초기 황반변성 환자에서 들쭉 추출물의 효과
The Efficacy of Vaccinium Uliginosum for Early Age-Related Macula Degeneration
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목적: 초기 황반변성 환자에서 망막의 미세구조에 영향을 줄 수 있는 들쭉 추출물의 효과를 알아보고자 하였다. 대상과 방법: 본 연구는 초기 황반변성 환자 44명의 44안에 대하여 무작위 배정, 이중맹검, 위약 대조군 비교를 통해 위약군 24명과들쭉 추출물 투약군 20명을 선정하였다. 투약 전과 투약 1개월 후, 투약 3개월 후에 각각 세극등 현미경 검사와 최대교정시력, 안압측정이 이루어졌으며, OQAS (Optical Quality Analysis System, Visiometrics, Spain)를 이용하여 객관적 시력, 객관적 빛 산란 지표,눈물층 등의 변화를 측정하고, 안구광학단층촬영(Spectralis, Heidelberg, Germany)으로 드루젠 크기 및 모양 변화, 중심황반두께 및망막색소상피(RPE)부터 광수용체층(photoreceptor layer)의 내분절과 외분절의 접합부(IS/OS junction)까지의 두께를 측정하였다. 결과: 들쭉 투약군은 위약군에 비해 투약 3개월 후에 유의하게 망막색소상피부터 광수용체층의 내분절과 외분절의 접합부까지의 두께가 증가하였다. 결론: 초기 황반변성에서 들쭉 추출물을 복용하는 것은 망막색소상피부터 광수용체층의 내분절과 외분절의 접합부까지의 두께의 얇아짐을 방지하고 강한 항산화 효과를 나타내어 황반변성의 진행을 억제하고 광수용체층의 위축을 예방하는 데에 효과가 있을 것으로생각한다.
Abstract
Purpose: To evaluate the effect of Bog Bilberry (Vaccinium uliginosum) extract in eyes with early age-related macular degeneration (AMD). Methods: Forty- four eyes of forty four patients with early AMD were included in this randomized, double-blinded, and placebo-controlled study. All participants were randomly assigned to either the placebo group (n = 24), or the bog bilberry extract group (n = 20). Before drug administration, an ophthalmic examination which included slit lamp microscopy, best corrected visual acuity, and intraocular pressure was performed, and repeated 1and 3 months after treatment. Objective scatter index, glare and tear film break-up time were checked by Optical Quality Analysis System (OQAS, Visiometrics, Spain)and drusen volume, central macular thickness, and RPE and IS/OS junction thickness were investigated with spectral-domain optical coherence tomography (Spectralis, Heidelberg, Germany). Results: In the bog bilberry extract group, RPE and IS/OS junction thickness was significantly increased compared to the placebo group after 3 months of drug administration. Conclusions: Bog Bilberry extract may play a favorable role in preventing the atrophic change of RPE and IS/OS junction layer and the progression of early macular degeneration.
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