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RTVue 빛간섭단층촬영기로 측정한 맥락막 두께와 연관인자에 관한 연구

Analysis of Choroidal Thickness Measured Using RTVue and Associated Factors in Open-Angle Glaucoma

노승수|최우석|진상욱|서홍융|노세현
대한안과학회 (The Korean Ophthalmological Society)|2015.07|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제56권 제7호|pp. 1065-1074

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참고문헌

키워드

Choroidal thicknessBlood pressure variabilityNocturnal dipRTVue
주제분류안과학

초록

목적: 정상안압녹내장(normal tension glaucoma, NTG) 및 원발성개방각녹내장(primary open angle glaucoma, POAG)에서 RTVue (Optovue, Fremont, CA, USA)를 이용하여 측정한 황반하와 유두 주위 맥락막 두께를 비교하고 이에 영향을 미치는 인자들에 대해알아보고자 하였다. 대상과 방법: 퓨리에 영역 빛간섭단층촬영(Fourier-domain optical coherence tomography, FD-OCT)으로 측정한 황반하와 유두 주위 맥락막, retinal nerve fiber layer (RNFL), 그리고 ganglion cell complex (GCC) 두께를 비교, 분석하였다. 또한 황반하와 유두주위 맥락막 두께에 영향을 미칠 수 있는 인자들과의 상관관계를 비교, 분석하였다. 결과: 정상 대조군 32명, POAG 32명, NTG 52명이 포함되었다. 각 군 간 맥락막 두께를 비교한 결과, 황반하와 유두 주위 맥락막두께는 NTG에서 가장 얇았다. NTG에서는 황반하와 유두 주위 맥락막 두께에 영향을 미치는 인자는 나이, 안축장, 이완기 혈압의야간혈압하강, 이완기 혈압의 변동성, GCC 두께였고, POAG에서는 나이, 안축장만이 영향을 미치는 인자였다. 결론: 정상인에 비해 POAG와 NTG에서 RTVue로 측정한 황반하와 유두 주위의 맥락막 두께가 더 얇았고 POAG보다 NTG에서 더얇았다. NTG에서는 나이, 안축장, 큰 폭의 이완기 야간혈압하강과 혈압의 변동성이, POAG에서는 나이, 안축장이 맥락막 두께에 영향을 미치는 인자였다.

Abstract

Purpose: To compare the macular choroidal thickness, ganglion cell complex thickness, peripapillary choroidal thickness and retinal nerve fiber layer thickness among normal, primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients using RTVue (Fourier-domain optical coherence tomography; Optovue, Fremont, CA, USA). Methods: A retrospective analysis of 32 normal controls, 32 POAG and 52 NTG patients was performed. Choroidal thickness, ganglion cell complex thickness and retinal nerve fiber layer thickness were compared among normal controls, POAG and NTG subjects. Additionally, the factors influencing choroidal thickness (age, axial length, spherical equivalent, central corneal thickness, mean deviation, nocturnal dip, blood pressure variability) were analyzed. Results: A total of 32 normal controls, 32 POAG and 52 NTG patients were enrolled in this study. Macular and peripapillary choroidal thicknesses were significantly thinner in the NTG patients. In NTG subjects, the significant influencing factors associated with macular and peripapillary choroidal thicknesses were age, axial length, nocturnal dip (diastolic blood pressure), diastolic blood pressure variability and ganglion cell complex thickness. In POAG patients, significant influencing factors associated with macular and peripapillary choroidal thicknesses were age and axial length. Conclusions: Choroidal thickness was significantly thinner in NTG patients compared with normal controls and POAG patients. Factors influencing choroidal thickness in NTG patients were age, axial length, nocturnal dip (diastolic blood pressure), diastolic blood pressure variability and ganglion cell complex thickness. In POAG patients, significant factors influencing choroidal thickness were age and axial length.

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