Cytomegalovirus Retinitis after Intravitreal Bevacizumab Injection in an Immunocompetent Patient
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
We report a case of cytomegalovirus (CMV) retinitis after intravitreal bevacizumab injection. A 61-year-old woman with diabetic macular edema developed dense vitritis and necrotizing retinitis 3 weeks after intravitreal bevacizumab injection. A diagnostic vitrectomy was performed. The undiluted vitreous sample acquired by vitrectomy was analyzed by polymerase chain reaction and culture. Polymerase chain reaction of the vitreous was positive for CMV DNA. Other laboratory results did not show evidence of other infectious retinitis and systemic immune dysfunction. Human immunodeficiency virus antibodies were also negative. After systemic administration of ganciclovir, retinitis has resolved and there has been no recurrence of retinitis during the follow-up period of 12 months. Ophthalmologists should be aware of potential risk for CMV retinitis after intravitreal bevacizumab injection.
Abstract
We report a case of cytomegalovirus (CMV) retinitis after intravitreal bevacizumab injection. A 61-year-old woman with diabetic macular edema developed dense vitritis and necrotizing retinitis 3 weeks after intravitreal bevacizumab injection. A diagnostic vitrectomy was performed. The undiluted vitreous sample acquired by vitrectomy was analyzed by polymerase chain reaction and culture. Polymerase chain reaction of the vitreous was positive for CMV DNA. Other laboratory results did not show evidence of other infectious retinitis and systemic immune dysfunction. Human immunodeficiency virus antibodies were also negative. After systemic administration of ganciclovir, retinitis has resolved and there has been no recurrence of retinitis during the follow-up period of 12 months. Ophthalmologists should be aware of potential risk for CMV retinitis after intravitreal bevacizumab injection.
참고문헌 (17)
- Markomichelakis NN, "Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy", Ophthalmology, 109, pp.879~882 (2002)
- Chee SP, "Corneal endotheliitis associated with evidence of cytomegalovirus infection", Ophthalmology, 114, pp.798~803 (2007)
- Van Boxtel LA, "Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients", Ophthalmology, 114, pp.1358~1362 (2007)
- De Schryver I, "Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis", Br J Ophthalmol, 90, pp.852~855 (2006)
- Wreghitt TG, "Cytomegalovirus infection in immunocompetent patients", Clin Infect Dis, 37, pp.1603~1606 (2003)
- Patra S, "Cytomegalovirus infection of the human gastrointestinal tract", J Gastroenterol Hepatol, 14, pp.973~976 (1999)
- Holland GN, "Cytomegalovirus retinitis, In Ocular infection and immunity", pp.1088~1129 (1996), Mosby
- Freeman WR, "A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome", Am J Ophthalmol, 97, pp.133~142 (1984)
- Stewart MW, "Cytomegalovirus retinitis in an immunocompetent patient", Arch Ophthalmol, 123, pp.572~574 (2005)
- Delyfer MN, "Cytomegalovirus retinitis following intravitreal injection of triamcinolone: report of two cases", Acta Ophthalmol Scand, 85, pp.681~683 (2007)
- Sekiryu T, "Cytomegalovirus retinitis after intravitreal triamcinolone acetonide in an immunocompetent patient", Jpn J Ophthalmol, 52, pp.414~416 (2008)
- Ufret-Vincenty RL, "Cytomegalovirus retinitis after fluocinolone acetonide (Retisert) implant", Am J Ophthalmol, 143, pp.334~335 (2007)
- Toyokawa N, "Cytomegalovirus retinitis after subtenon triamcinolone acetonide and intravitreal injection of anti-vascular endothelial growth factor in an immunocompetent patient with age-related macular degeneration and diabetes mellitus", Jpn J Ophthalmol, 54, pp.166~168 (2010)
- Boeckh M, "Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity", Blood, 101, pp.407~414 (2003)
- Mhiri L, "Comparison of pp65 antigenemia, quantitative PCR and DNA hybrid capture for detection of cytomegalovirus in transplant recipients and AIDS patients", J Virol Methods, 143, pp.23~28 (2007)
- Ljungman P, "Definitions of cytomegalovirus infection and disease in transplant recipients", Clin Infect Dis, 34, pp.1094~1097 (2002)
- Zhang M, "Murine cytomegalovirus (MCMV) spreads to and replicates in the retina after endotoxin-induced disruption of the blood-retinal barrier of immunosuppressed BALB", c mice, 2005, pp.11, 365~375