Topographic Progression of Keratoconus in the Korean Population
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Purpose: To develop a criterion for determining the topographic progression of keratoconus and to analyze the prognostic factors of progression. Methods: Medical records of 211 eyes of 128 patients who had been followed up for more than 2 years on three or more occasions were retrospectively reviewed. Topographic parameters, including simulated K, corneal astigmatism, irregular astigmatism at 3 and 5 mm, thinnest-point pachymetry, anterior and posterior elevation,and inferior minus superior index, were used to determine topographic progression. Topographic progression was determined by the greatest kappa value associated with progression to corneal graft surgery. Eyes were separated into progressed and non-progressed groups on the basis of topographic progression. The association of clinical factors with topographic progression, including demographic factors, contact lens use, corneal erosion, and atopic history at the time of diagnosis, was assessed by logistic regression. Results: When topographic progression was defined as five or more progressed topographic parameters, the greatest kappa value (0.354) was obtained. Ninety-four of the 211 keratoconic eyes (44.5%) were identified as topographically progressed. Age at diagnosis was significantly different between the progressed and nonprogressed groups (22.2 vs. 24.7 years, p = 0.014). Logistic regression revealed that younger age at diagnosis was a risk factor for topographic progression (odds ratio, 0.948; 95% confidence interval, 0.907 to 0.991; p =0.010). Conclusions: We developed a criterion for evaluating topographic progression of keratoconus using diverse topographic indices. Younger age at diagnosis was associated with topographic progression of keratoconus.
Abstract
Purpose: To develop a criterion for determining the topographic progression of keratoconus and to analyze the prognostic factors of progression. Methods: Medical records of 211 eyes of 128 patients who had been followed up for more than 2 years on three or more occasions were retrospectively reviewed. Topographic parameters, including simulated K, corneal astigmatism, irregular astigmatism at 3 and 5 mm, thinnest-point pachymetry, anterior and posterior elevation,and inferior minus superior index, were used to determine topographic progression. Topographic progression was determined by the greatest kappa value associated with progression to corneal graft surgery. Eyes were separated into progressed and non-progressed groups on the basis of topographic progression. The association of clinical factors with topographic progression, including demographic factors, contact lens use, corneal erosion, and atopic history at the time of diagnosis, was assessed by logistic regression. Results: When topographic progression was defined as five or more progressed topographic parameters, the greatest kappa value (0.354) was obtained. Ninety-four of the 211 keratoconic eyes (44.5%) were identified as topographically progressed. Age at diagnosis was significantly different between the progressed and nonprogressed groups (22.2 vs. 24.7 years, p = 0.014). Logistic regression revealed that younger age at diagnosis was a risk factor for topographic progression (odds ratio, 0.948; 95% confidence interval, 0.907 to 0.991; p =0.010). Conclusions: We developed a criterion for evaluating topographic progression of keratoconus using diverse topographic indices. Younger age at diagnosis was associated with topographic progression of keratoconus.
참고문헌 (19)
- Krachmer JH, "Keratoconus and related noninflammatory corneal thinning disorders", Surv Ophthalmol, 28, pp.293~322 (1984)
- Rabinowitz YS, "Keratoconus", Surv Ophthalmol, 42, pp.297~319 (1998)
- Caporossi A, "Longterm results of ribof lavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena Eye Cross Study", Am J Ophthalmol, 149, pp.585~593 (2010)
- El-Raggal TM., "Ribof lavin-ultraviolet a corneal crosslinking for keratoconus", Middle East Afr J Ophthalmol, 16, pp.256~259 (2009)
- Ertan A, "Effect of age on outcomes in patients with keratoconus treated by Intacs using a femtosecond laser", J Refract Surg, 24, pp.690~695 (2008)
- Kang YS, "The effect of the YK lens in keratoconus", Ophthalmic Physiol Opt, 30, pp.267~273 (2010)
- Sahin A, "Two-year interval changes in Orbscan II topography in eyes with keratoconus", J Cataract Refract Surg, 34, pp.1295~1299 (2008)
- Tuft SJ, "Prognostic factors for the progression of keratoconus", Ophthalmology, 101, pp.439~447 (1994)
- Weed KH, "The Dundee University Scottish Keratoconus Study II: a prospective study of optical and surgical correction", Ophthalmic Physiol Opt, 27, pp.561~567 (2007)
- Kim H, "Measure of keratoconus progression using Orbscan II", J Refract Surg, 24, pp.600~605 (2008)
- Joon Seo Hwang, "Effects of Multicurve RGP Contact Lens Use on Topographic Changes in Keratoconus", Korean Journal of Ophthalmology, 24(4), pp.201~206 (2010), 대한안과학회
- Li X, "Longitudinal study of keratoconus progression", Exp Eye Res, 85, pp.502~507 (2007)
- Reeves SW, "Risk factors for progression to penetrating keratoplasty in patients with keratoconus", Am J Ophthalmol, 140, pp.607~611 (2005)
- Landis JR, "measurement of observer agreement for categorical data", Biometrics, 33, pp.159~174 (1977)
- Viera AJ, "Understanding interobserver agreement: the kappa statistic", Fam Med, 37, pp.360~363 (2005)
- Pouliquen Y, "Evaluation of the rapidity of progression of keratoconus by a study of the relationship between age when first detected and age at operation", J Fr Ophtalmol, 4, pp.219~221 (1981)
- McMahon TT, "Longitudinal changes in corneal curvature in keratoconus", Cornea, 25, pp.296~305 (2006)
- Shirayama-Suzuki M, "Longitudinal analysis of corneal topography in suspected keratoconus", Br J Ophthalmol, 93, pp.815~819 (2009)
- Oshika T, "Progression of keratoconus assessed by fourier analysis of videokeratography data", Ophthalmology, 109, pp.339~342 (2002)