비접촉 마이봄샘촬영술을 이용한 한국인에서 연령에 따른 마이봄샘의 변화 연구
Changes of the Meibomian Gland According to Age in the Normal Korean Population
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목적: 비접촉 마이봄샘촬영술을 이용하여 한국인에서 연령에 따른 마이봄샘의 변화를 알아보고 마이봄샘의 구조가 상안검과 하안검간에 차이가 있는지 알아보고자 하였다. 대상과 방법: 20세 이상 성인을 대상으로 하여 상안검과 하안검의 마이봄샘을 적외선 카메라로 촬영하였으며, 마이봄샘의 소실에 따른 각 안검의 마이봄점수(Meiboscore)를 매긴 후, 상하안검의 값을 합한 점수를 총 마이봄점수로 정의하였다. 연령, 성별에 따라 마이봄점수의 차이를 비교해 보았으며 연령 및 안검 위치에 따른 마이봄점수의 변화를 분석해 보았다. 결과: 117명 117안을 대상으로 평균 나이는 50.4 ± 19.1세였다. 연령에 따라 총 마이봄점수, 상하안검의 마이봄점수는 유의하게 증가하였다(r=0.578, p＜0.001; r=0.550, p＜0.001; r=0.524, p＜0.001). 마이봄점수는 40대 이후부터 마이봄점수가 유의하게 높게 나타났으며, 상안검과 하안검 간에 차이는 없었다. 결론: 한국인 성인에서 비접촉마이봄샘촬영술을 시행하였을 때, 마이봄샘 변화의 유병률은 약 60%였으며, 연령이 증가함에 따라 마이봄샘의 변화도 증가하는 것으로 보여진다.
Abstract
Purpose: To examine the changes in meibomian glands associated with aging in a normal Korean population and to estimate thedifferences between the upper and lower eyelid in each age group. Methods: We performed meibography on adult subjects using an infrared charge-coupled device (CCD) camera. Each eyelidwas scored based on the loss of meibomian glands, and the meiboscores of the upper and lower eyelids were summed to obtaina score for each eye. Meiboscores were evaluated according to age, sex, and upper and lower eyelid meiboscores in each agegroup. Results: One hundred seventeen eyes of 117 people were enrolled in this study. The study subjects had an average age of 50.4± 19.1 years (range, 20-92; male, 56; female, 61). There was a significant positive correlation between age and total meiboscore,upper and lower eyelid meiboscore (r = 0.578, p < 0.001; r = 0.550, p < 0.001; r = 0.524, p < 0.001). There were no significant differencesin the meiboscores of the upper and lower eyelids in any age group, though meiboscores were significantly higher since40 year-old group than 20 year-old group (p < 0.001, p < 0.001, p < 0.001, p < 0.001). Conclusions: Based on noncontact meibography in normal adult eyes, the authors concluded that prevalence of changes in themeibomian glands was about 60% and changes in meibomian glands increase with age.
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