안검 모낭충 감염군과 안구건조증 환자 중 비감염군에서의 마이봄샘 소실 비교
Comparison of Meibomian Gland Loss between Demodex-infested Group and Dry Eye Patients without Demodex Infestation
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목적: 비접촉 마이봄샘촬영술을 이용하여 눈꺼풀 모낭충 감염 여부에 따른 마이봄샘 소실 정도를 비교하고자 하였다. 대상과 방법: 저자들은 눈꺼풀 모낭충에 감염된 24명의 성인 환자와 감염되지 않은 40명의 환자를 대상으로 적외선 디지털 카메라를 사용하여 비접촉 마이봄샘촬영술을 시행하였다. 마이봄샘의 소실을 기준으로 오른쪽 눈의 위눈꺼풀과 아래눈꺼풀의 마이봄점수를 합하여 각 피험자에 대한 전체 마이봄점수를 구했다. 각 그룹의 눈꺼풀 모낭충 감염 여부 및 성별에 따라 마이봄점수를 평가하였다. 결과: 64명 64안이 연구에 등록되었으며, 평균 나이는 67.9세(40-79세, 남자 65.2세, 여자 69.1세)였다. 눈꺼풀 모낭충 감염과 총 마이봄점수, 위 및 아래눈꺼풀 마이봄점수 사이에 유의한 연관성이 있었다(각각, p=0.000, p=0.002, p=0.004). 마이봄점수는 남자와 여자 사이에 유의한 차이가 없었다. 연령과 마이봄점수 사이에 양의 상관 관계가 시사되었으나, 본 연구에서는 집중된 연령 분포로 인해 R2 값이 낮았다. 결론: 비접촉 마이봄샘촬영술을 이용한 검사에서 눈꺼풀 모낭충 감염이 마이봄샘 변화와 유의한 관련이 있었다.
Abstract
Purpose: To compare the degree of meibomian gland drop-out associated with Demodex infestation using non-contact meibography. Methods: We performed noncontact meibography using an infrared digital camera on 24 adult subjects infested by Demodex and 40 without infestation. The right upper and lower lids were scored based on the loss of meibomian glands, and the scores of the upper and lower eyelids were summed to obtain the total meiboscore for each subject. Meiboscores were evaluated according to Demodex infestation and gender in each group. Results: Sixty-four eyes of 64 people were enrolled in this study. The study subjects had an average age of 67.9 years (range, 40-79 years; men, 65.2 years; women, 69.1 years). There was a significant association between Demodex infestation and total meiboscore and upper and lower eyelid meiboscores (p = 0.000, p = 0.002, p = 0.004, respectively). There was no significant difference in the meiboscores between men and women. Age and meiboscore suggested a weak positive correlation; however, the R2 value was low, due to the concentrated age distribution of the study population. Conclusions: Based on noncontact meibography, the authors concluded that the prevalence of changes in the meibomian glands was significantly related to Demodex infestation; however, there was no significant difference between men and women.
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