Changes in Tear Volume after 3% Diquafosol Treatment in Patients with Dry Eye Syndrome: An Anterior Segment Spectral-domain Optical Coherence Tomography Study
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Purpose: To evaluate changes in the tear meniscus area and tear meniscus height over time in patients withdry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillationof 3% diquafosol ophthalmic solution. Methods: Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscusimages acquired by anterior segment spectral-domain optical coherence tomography were analyzed usingNational Institutes of Health’s image-analysis software (ImageJ 1.44p). Tear meniscus area and tear meniscusheight were measured at baseline, 5 minutes, 10 minutes, and 30 minutes after instillation of a drop of diquafosolin one eye and normal saline in the other eye. Changes in ocular surface disease index score, tear filmbreak-up time, corneal staining score by Oxford schema, and meibomian expressibility were also evaluated atbaseline, and after 1 week and 1 month of a diquafosol daily regimen. Results: Sixty eyes from 30 subjects (mean age, 29.3 years; 8 men and 22 women) were included. In eyes receivingdiquafosol, tear volume was increased at 5 and 10 minutes compared with baseline. It was also higherthan saline instilled eyes at 5, 10, and 30 minutes. Changes in tear volume with respect to baseline were notstatistically different after the use of diquafosol for 1 month. Ocular surface disease index score, tear filmbreak-up time, and Oxford cornea stain score were significantly improved after 1 week and 1 month of dailydiquafosol instillation, but meibomian expressibility did not change. Conclusions: Topical diquafosol ophthalmic solution effectively increased tear volume for up to 30 minutes,compared to normal saline in patients with dry eye syndrome.
Abstract
Purpose: To evaluate changes in the tear meniscus area and tear meniscus height over time in patients withdry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillationof 3% diquafosol ophthalmic solution. Methods: Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscusimages acquired by anterior segment spectral-domain optical coherence tomography were analyzed usingNational Institutes of Health’s image-analysis software (ImageJ 1.44p). Tear meniscus area and tear meniscusheight were measured at baseline, 5 minutes, 10 minutes, and 30 minutes after instillation of a drop of diquafosolin one eye and normal saline in the other eye. Changes in ocular surface disease index score, tear filmbreak-up time, corneal staining score by Oxford schema, and meibomian expressibility were also evaluated atbaseline, and after 1 week and 1 month of a diquafosol daily regimen. Results: Sixty eyes from 30 subjects (mean age, 29.3 years; 8 men and 22 women) were included. In eyes receivingdiquafosol, tear volume was increased at 5 and 10 minutes compared with baseline. It was also higherthan saline instilled eyes at 5, 10, and 30 minutes. Changes in tear volume with respect to baseline were notstatistically different after the use of diquafosol for 1 month. Ocular surface disease index score, tear filmbreak-up time, and Oxford cornea stain score were significantly improved after 1 week and 1 month of dailydiquafosol instillation, but meibomian expressibility did not change. Conclusions: Topical diquafosol ophthalmic solution effectively increased tear volume for up to 30 minutes,compared to normal saline in patients with dry eye syndrome.
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