Clinical Results of Various Treatments for Retinal Capillary Hemangioma
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Purpose: We report the clinical outcomes of retinal capillary hemangioma (RCH) after the application of varioustreatments. Methods: We performed a retrospective chart analysis of eight eyes treated for RCH between August 2009 andJanuary 2018. During the follow-up period, the status and progression of the RCHs were checked by fundusphotography, fluorescein angiography, and optical coherence tomography, and additional treatments were appliedwhen necessary. Results: Three of the five patients had bilateral RCH, and two had unilateral RCH. Six eyes received laser photocoagulation;two eyes received cryotherapy, and one eye received intravitreal Avastin injection. Three eyeseach had intravitreal triamcinolone injection, subtenon triamcinolone injection, and intravitreal dexamethasoneinjection to control inflammation. Also, two patients took oral prednisolone, and one patient used prednisoloneeye drops to control inflammation. Two eyes underwent vitrectomy and scleral buckling due to deteriorationof the epiretinal membrane and vitreal traction, respectively. As a result of those treatments, the tumors werestable in five of the eight eyes. However, one eye is now in a pre-phthisis state, and one patient who refusedtreatment showed progression of the tumor, epiretinal membrane, and traction. Conclusions: Because RCHs vary in size, the degree of inflammation, and symptoms, this disorder should beactively treated on a case-by-case basis. Fluorescein angiography should be used periodically to determinerecurrence of the tumor or inflammation, and the appropriate treatment should be repeated as necessary. Moreover, regular systemic screening tests for von Hippel-Lindau disease should be performed in RCH patientsto ensure that they have no abnormalities other than in the eye.
Abstract
Purpose: We report the clinical outcomes of retinal capillary hemangioma (RCH) after the application of varioustreatments. Methods: We performed a retrospective chart analysis of eight eyes treated for RCH between August 2009 andJanuary 2018. During the follow-up period, the status and progression of the RCHs were checked by fundusphotography, fluorescein angiography, and optical coherence tomography, and additional treatments were appliedwhen necessary. Results: Three of the five patients had bilateral RCH, and two had unilateral RCH. Six eyes received laser photocoagulation;two eyes received cryotherapy, and one eye received intravitreal Avastin injection. Three eyeseach had intravitreal triamcinolone injection, subtenon triamcinolone injection, and intravitreal dexamethasoneinjection to control inflammation. Also, two patients took oral prednisolone, and one patient used prednisoloneeye drops to control inflammation. Two eyes underwent vitrectomy and scleral buckling due to deteriorationof the epiretinal membrane and vitreal traction, respectively. As a result of those treatments, the tumors werestable in five of the eight eyes. However, one eye is now in a pre-phthisis state, and one patient who refusedtreatment showed progression of the tumor, epiretinal membrane, and traction. Conclusions: Because RCHs vary in size, the degree of inflammation, and symptoms, this disorder should beactively treated on a case-by-case basis. Fluorescein angiography should be used periodically to determinerecurrence of the tumor or inflammation, and the appropriate treatment should be repeated as necessary. Moreover, regular systemic screening tests for von Hippel-Lindau disease should be performed in RCH patientsto ensure that they have no abnormalities other than in the eye.
참고문헌 (38)
- Singh AD, "von Hippel-Lindau disease", Surv Ophthalmol, 46, pp.117~142 (2001)
- Lamiell JM, "von Hippel-Lindau disease affecting 43 members of a single kindred", Medicine(Baltimore), 68, pp.1~29 (1989)
- Shields JA, "Intraocular tumors: an atlas and textbook", pp.368~369 (2008), Lippincott Williams &Wilkins
- Maher ER, "Clinical features and natural history of von Hippel-Lindau disease", Q J Med, 77, pp.1151~1163 (1990)
- Webster AR, "Clinical characteristics of ocular angiomatosis in von Hippel-Lindau disease and correlation with germline mutation", Arch Ophthalmol, 117, pp.371~378 (1999)
- Ridley M, "Retinal angiomatosis : the ocular manifestations of von Hippel-Lindau disease", Can J Ophthalmol, 21, pp.276~283 (1986)
- Annesley WH Jr, "Fifteen year review of treated cases of retinal angiomatosis", Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol, 83, pp.OP446~OP453 (1977)
- Singh AD, "Clinical ophthalmic oncology: basic principles", pp.99~105 (2019), Springer
- 이동수, "망막박리가 발생된 von Hippel-Lindau 증후군의 치험 2예", 대한안과학회지, 42(11), pp.1636~1640 (2001), 대한안과학회
- 백승국, "망막앞막이 동반된 다발성 망막 모세혈관종에서 시행한 일차유리체절제술 1예", 대한안과학회지, 55(6), pp.928~935 (2014), 대한안과학회
- Whitson JT, "Von Hippel-Lindau disease : case report of a patient with spontaneous regression of a retinal angioma", Retina, 6, pp.253~259 (1986)
- Oosterhuis JA, "Haemangioma at the optic disc", Ophthalmologica, 164, pp.362~374 (1972)
- Sachdeva R, "Verteporfin photodynamic therapy of six eyes with retinal capillary haemangioma", Acta Ophthalmol, 88, pp.e334~e340 (2010)
- Fong AH, "Intravitreal ranibizumab, photodynamic therapy, and vitreous surgery for the treatment of juxtapapillary retinal capillary hemangioma", Graefes Arch Clin Exp Ophthalmol, 249, pp.625~627 (2011)
- Kremer I, "Juxtapapillary exophytic retinal capillary hemangioma treated by yellow krypton(568 nm)laser photocoagulation", Ophthalmic Surg, 19, pp.743~747 (1988)
- Gaudric A, "Vitreoretinal surgery for severe retinal capillary hemangiomas in von hippel-lindau disease", Ophthalmology, 118, pp.142~149 (2011)
- McDonald HR, "Vitrectomy in eyes with peripheral retinal angioma associated with traction macular detachment", Ophthalmology, 103, pp.329~335 (1996)
- Johnson MW, "Pars plana vitrectomy and direct diathermy for complications of multiple retinal angiomas", Ophthalmic Surg, 23, pp.47~50 (1992)
- Chew EY, "Retina", pp.2013, Saunders
- 이효진, "망막박리와 동반된 망막모세혈관종 3예", 대한안과학회지, 44(8), pp.32~1942 (2003), 대한안과학회
- Carr RE, "Retinal angiomatosis", Ophthalmology, 87, pp.956~959 (1980)
- Singh A, "Solitary retinal capillary hemangioma : hereditary(von Hippel-Lindau disease)or nonhereditary", Arch Ophthalmol, 119, pp.232~234 (2001)
- Hinz BJ, "Retina", pp.615~624 (2006), Mosby
- 김형민, "Massive Exudative Retinal Detachment Following Photodynamic Therapy and Intravitreal Bevacizumab Injection in Retinal Capillary Hemangioma", Korean Journal of Ophthalmology, 29(2), pp.143~145 (2015), 대한안과학회
- Schmidt D, "Long-term results of laser treatment for retinal angiomatosis in von Hippel-Lindau disease", Eur J Med Res, 5, pp.47~58 (2000)
- Shields JA, "The expanding role of laser photocoagulation for intraocular tumors. The 1993 H. Christian Zweng Memorial Lecture", Retina, 14, pp.310~322 (1994)
- Lane CM, "Laser treatment of retinal angiomatosis", Eye(Lond), 3, pp.33~38 (1989)
- Amoils SP, "Cryotherapy of angiomatosis retinae", Arch Ophthalmol, 81, pp.689~691 (1969)
- Shields JA, "Response of retinal capillary hemangioma to cryotherapy", Arch Ophthalmol, 111, pp.551~ (1993)
- Welch RB, "Von Hippel-Lindau disease : the recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy", Trans Am Ophthalmol Soc, 68, pp.367~424 (1970)
- Singh AD, "Treatment of retinal capillary hemangioma", Ophthalmology, 109, pp.1799~1806 (2002)
- Watzke RC, "Cryotherapy for retinal angiomatosis : a clinicopathologic report", Arch Ophthalmol, 92, pp.399~401 (1974)
- Los M, "Elevated ocular levels of vascular endothelial growth factor in patients with von Hippel-Lindau disease", Ann Oncol, 8, pp.1015~1022 (1997)
- Ach T, "Intravitreal bevacizumab for retinal capillary haemangioma : longterm results", Acta Ophthalmol, 88, pp.e137~e138 (2010)
- Chelala E, "Intravitreal anti-VEGF injection for the treatment of progressive juxtapapillary retinal capillary hemangioma : a case report and mini review of the literature", Clin Ophthalmol, 7, pp.2143~2146 (2013)
- Atebara NH, "Retinal capillary hemangioma treated with verteporfin photodynamic therapy", Am J Ophthalmol, 134, pp.788~790 (2002)
- Rodriguez-Coleman H, "Treatment of angiomatous lesions of the retina with photodynamic therapy", Retina, 22, pp.228~232 (2002)
- Shin Cho Suh, "Retinal Capillary Hemangioma Treated with Verteporfin Photodynamic Therapy and Intravitreal Triamcinolone Acetonide", Korean Journal of Ophthalmology, 21(3), pp.178~184 (2007), 대한안과학회