Application of Intravitreal Bevacizumab for Circumscribed Choroidal Hemangioma
3
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
We report 3 cases of circumscribed choroidal hemangioma (CCH) effectively managed with intravitreal bevacizumab. One patient (case 1) who had recurrent CCH (1.6 ㎜ in thickness) with prior laser photocoagulation was treated with intravitreal bevacizumab alone. Two patients (case 2 and 3) who had CCH (2.4 ㎜ and 2.2 ㎜ in thickness, respectively) with recent visual impairment were treated with bevacizumab followed by photodynamic therapy (PDT). Ophthalmic evaluations included visual acuity, ophthalmoscopic examination, fluorescein angiography, ultrasonography, and optical coherence tomography. Patients were followed up for 6-9 months. After therapy, all patients showed improved visual acuity due to complete resorption of subretinal fluid and macular edema. Ultrasonography demonstrated a reduction of the thickness of CCH in case 1 and complete regression of the lesions in case 2 and 3. No patient showed tumor recurrence. Intravitreal bevacizumab, alone or in combination therapy with PDT, may be a useful alternative for the treatment of symptomatic CCH with subretinal fluid.
Abstract
We report 3 cases of circumscribed choroidal hemangioma (CCH) effectively managed with intravitreal bevacizumab. One patient (case 1) who had recurrent CCH (1.6 ㎜ in thickness) with prior laser photocoagulation was treated with intravitreal bevacizumab alone. Two patients (case 2 and 3) who had CCH (2.4 ㎜ and 2.2 ㎜ in thickness, respectively) with recent visual impairment were treated with bevacizumab followed by photodynamic therapy (PDT). Ophthalmic evaluations included visual acuity, ophthalmoscopic examination, fluorescein angiography, ultrasonography, and optical coherence tomography. Patients were followed up for 6-9 months. After therapy, all patients showed improved visual acuity due to complete resorption of subretinal fluid and macular edema. Ultrasonography demonstrated a reduction of the thickness of CCH in case 1 and complete regression of the lesions in case 2 and 3. No patient showed tumor recurrence. Intravitreal bevacizumab, alone or in combination therapy with PDT, may be a useful alternative for the treatment of symptomatic CCH with subretinal fluid.
참고문헌 (30)
- Green WR, "Ophthalmic Pathology: An Atlas and Textbook, 3 rd ed" (1986), Saunders
- Witschel H, "Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature", Surv Ophthalmol, 20, pp.415~431 (1976)
- Mashayekhi A, "Circumscribed choroidal hemangioma", Curr Opin Ophthalmol, 14, pp.142~149 (2003)
- Anand R, "Circumscribed choroidal hemangiomas", Arch Ophthalmol, 1107, pp.1338~1342 (1989)
- Augsburger JJ, "Circumscribed choroidal hemangiomas: long-term visual prognosis", Retina, 1, pp.56~61 (1981)
- Shields CL, "Circumscribed choroidal hemangioma: clinical manifestations and factors predictive of visual outcome in 200 consecutive cases", Ophthalmology, 108, pp.2237~2248 (2001)
- Sanborn GE, "Treatment of circumscribed choroidal hemangiomas", Ophthalmology, 89, pp.1374~1380 (1982)
- Humphrey WT, "Choroidal hemangioma: Response to cryotherapy", Ann Ophthalmol, 11, pp.100~104 (1979)
- Chao AN, "Plaque radiotherapy for choroidal hemangioma with total retinal detachment and iris neovascularization", Retina, 21, pp.682~684 (2001)
- Ritland JS, "External beam irradiation therapy for choroidal haemangiomas: visual and anatomical results after a dose of 20 to 25 Gy", Acta Ophthalmol Scand, 79, pp.184~186 (2001)
- Guyer DR, "Radiation maculopathy after proton beam irradiation for choroidal hemangioma", Ophthalmology, 99, pp.1278~1285 (1992)
- Furst CJ, "Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden", J Natl Cancer Inst, 80, pp.1387~1392 (1988)
- Garcia-Arumi J, "Transpupillary thermotherapy for circumscribed choroidal hemangiomas", Ophthalmology, 107, pp.351~356 (2000)
- Barbazetto I, "Photodynamic therapy of choroidal hemangioma: two case reports", Graefes Arch Clin Exp Ophthalmol, 238, pp.214~221 (2000)
- Schmidt-Erfurth UM, "Photodynamic therapy for symptomatic choroidal hemangioma: visual and anatomic results", Ophthalmology, 109, pp.2284~2294 (2002)
- Porrini G, "Photodynamic therapy of circumscribed choroidal hemangioma", Ophthalmology, 110, pp.674~680 (2003)
- Michels S, "Verteporfin therapy for choroidal hemangioma: a long-term follow-up", Retina, 25, pp.697~703 (2005)
- Rosenfeld PJ, "Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration", Ophthalmology, 112, pp.1048~1053 (2005)
- Mason JO 3rd, "Intravitreal injection of bevacizumab (Avastin) as adjunctive treatment of proliferative diabetic retinopathy", Am J Ophthalmol, 142, pp.685~688 (2006)
- Rosenfeld PJ, "Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration", Ophthalmic Surg Lasers Imaging, 36, pp.331~335 (2005)
- Rosenfeld PJ, "Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for macular edema form central retinal vein occlusion", Ophthalmic Surg Lasers Imaging, 36, pp.336~339 (2005)
- Haritoglou C, "Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema", Retina, 26, pp.999~1005 (2006)
- Kahook MY, "Needle bleb revision of encapsulated filtering bleb with bevacizumab", Ophthlamic Surg Lasers Imaging, 37, pp.148~150 (2006)
- Kenawy N, "Treatment of a vasoproliferative tumour with intravitreal bevacizumab (Avastin)", Eye, 21, pp.893~894 (2007)
- Ziemssen F, "Combined treatment of a juxtapapillary retinal capillary haemangioma with intravitreal bevacizumab and photodynamic therapy", Eye, 21, pp.1125~1126 (2007)
- 정송이, "국한성 맥락막혈관종 7예", 대한안과학회지, 47(3), pp.368~5 (2006), 대한안과학회
- Mason JO 3rd, "Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema", Retina, 26, pp.356~357 (2006)
- Finger PT, "Anti-vascular endothelial growth factor bevacizumab (Avastin) for radiation retinopathy", Arch Ophthalmol, 125, pp.751~756 (2007)
- Wang W, "VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly", Am J Physiol Heart Circ Physiol, 280, pp.h434~h440 (2001)
- Schmidt-Erfurth U, "Photodynamic therapy of experimental choroidal melanoma using lipoprotein-delivered benzoporphyrin", Ophthalmology, 101, pp.89~99 (1994)