Serum Concentration of Vascular Endothelial Growth Factor after Bilateral Intravitreal Injection of Bevacizumab
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Purpose: This study compared serum vascular endothelial growth factor (VEGF) concentration between patientsgiven the bilateral and unilateral intravitreal injections of bevacizumab. Methods: In a prospective manner, serum VEGF levels in treatment-naive patients with age-related macular degenerationwho underwent bilateral or unilateral intravitreal injections of bevacizumab were investigated. Afterinformed consent, peripheral blood was collected from in patients who underwent bilateral or unilateral intravitrealinjection of bevacizumab before and 1 month after the injection. Serum VEGF levels were measured byenzyme-linked immunosorbent assay after centrifugation. In addition, best-corrected visual acuity (BCVA) andcentral retinal thickness (CRT) before and 1 month after the injection were compared between each group. Results: Twenty patients received bilateral injections (40 eyes) and 20 patients received unilateral injections. The VEGF concentrations (pg/mL) before the bilateral injection were 235.75 ± 183.16 and 252.53 ± 233.52 forthe unilateral injection. They were significantly reduced to 153.88 ± 113.26 and 189.42 ± 251.72 after 1 month,respectively (p = 0.037 and 0.019), which are showing no significant difference between the two groups (p =0.771). And there were no significant intergroup difference in pre- and postoperative BCVA and CRT. Conclusions: The bilateral simultaneous intravitreal injection of bevacizumab did not differ greatly from unilateralintravitreal injection in the influence on serum VEGF levels and the therapeutic outcome.
Abstract
Purpose: This study compared serum vascular endothelial growth factor (VEGF) concentration between patientsgiven the bilateral and unilateral intravitreal injections of bevacizumab. Methods: In a prospective manner, serum VEGF levels in treatment-naive patients with age-related macular degenerationwho underwent bilateral or unilateral intravitreal injections of bevacizumab were investigated. Afterinformed consent, peripheral blood was collected from in patients who underwent bilateral or unilateral intravitrealinjection of bevacizumab before and 1 month after the injection. Serum VEGF levels were measured byenzyme-linked immunosorbent assay after centrifugation. In addition, best-corrected visual acuity (BCVA) andcentral retinal thickness (CRT) before and 1 month after the injection were compared between each group. Results: Twenty patients received bilateral injections (40 eyes) and 20 patients received unilateral injections. The VEGF concentrations (pg/mL) before the bilateral injection were 235.75 ± 183.16 and 252.53 ± 233.52 forthe unilateral injection. They were significantly reduced to 153.88 ± 113.26 and 189.42 ± 251.72 after 1 month,respectively (p = 0.037 and 0.019), which are showing no significant difference between the two groups (p =0.771). And there were no significant intergroup difference in pre- and postoperative BCVA and CRT. Conclusions: The bilateral simultaneous intravitreal injection of bevacizumab did not differ greatly from unilateralintravitreal injection in the influence on serum VEGF levels and the therapeutic outcome.
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