Diurnal Intraocular Pressure with Bimatoprost/Timolol Fixed Combination versus Latanoprost/Timolol Fixed Combination in Healthy Subjects
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Purpose: To evaluate the effects of a bimatoprost/timolol fixed combination (BTFC) and a latanoprost/timolol fixedcombination (LTFC) on diurnal intraocular pressure (IOP) and anterior ocular parameters in healthy subjects. Methods: We enrolled 58 healthy subjects in this prospective clinical study. Thirty subjects were treated withBTFC and 28 subjects were treated with LTFC. IOP was measured every 2 hours except from 01:00 and05:00. Axial length, corneal curvature, and anterior chamber depth were obtained using the IOL master atbaseline and 24 hours later. Adverse events were assessed by patient interview and by slit lamp examination. Results: The largest difference in IOP between treated and untreated eyes 8 hours after instillation was 1.67mmHg in the BTFC group (p < 0.001). The largest difference in IOP between treated and untreated eyes 10hours after instillation was 1.93 mmHg in the LTFC group (p < 0.001). For anterior ocular parameters such asaxial length, corneal curvature, anterior chamber depth at baseline and 24 hours after instillation, there wereno significant differences between the baseline and 24-hour values in either the BTFC or LTFC group. Themost frequently occurring adverse event was conjunctival hyperemia, which was found in 33.3% (n = 10) ofthe BTFC group and 25.0% (n = 7) of the LTFC group (p = 0.486). Conclusions: BTFC and LTFC provided a significant reduction in IOP from baseline without changing any anteriorocular parameters. Our results provide a reference for monocular trials to assess the effect of eye drops ina clinical condition.
Abstract
Purpose: To evaluate the effects of a bimatoprost/timolol fixed combination (BTFC) and a latanoprost/timolol fixedcombination (LTFC) on diurnal intraocular pressure (IOP) and anterior ocular parameters in healthy subjects. Methods: We enrolled 58 healthy subjects in this prospective clinical study. Thirty subjects were treated withBTFC and 28 subjects were treated with LTFC. IOP was measured every 2 hours except from 01:00 and05:00. Axial length, corneal curvature, and anterior chamber depth were obtained using the IOL master atbaseline and 24 hours later. Adverse events were assessed by patient interview and by slit lamp examination. Results: The largest difference in IOP between treated and untreated eyes 8 hours after instillation was 1.67mmHg in the BTFC group (p < 0.001). The largest difference in IOP between treated and untreated eyes 10hours after instillation was 1.93 mmHg in the LTFC group (p < 0.001). For anterior ocular parameters such asaxial length, corneal curvature, anterior chamber depth at baseline and 24 hours after instillation, there wereno significant differences between the baseline and 24-hour values in either the BTFC or LTFC group. Themost frequently occurring adverse event was conjunctival hyperemia, which was found in 33.3% (n = 10) ofthe BTFC group and 25.0% (n = 7) of the LTFC group (p = 0.486). Conclusions: BTFC and LTFC provided a significant reduction in IOP from baseline without changing any anteriorocular parameters. Our results provide a reference for monocular trials to assess the effect of eye drops ina clinical condition.
참고문헌 (46)
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