Changes in Macular Retinal Layers and Peripapillary Nerve Fiber Layer Thickness after 577-nm Pattern Scanning Laser in Patients with Diabetic Retinopathy
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Purpose: The aim of this study was to evaluate the changes in thickness of each macular retinal layer, theperipapillary retinal nerve fiber layer (RNFL), and central macular thickness (CMT) after 577-nm pattern scanninglaser (PASCAL) photocoagulation in patients with diabetic retinopathy. Methods: This retrospective study included 33 eyes with diabetic retinopathy that underwent 577-nm PASCALphotocoagulation. Each retinal layer thickness, peripapillary RNFL thickness, and CMT were measured byspectral-domain optical coherence tomography before 577-nm PASCAL photocoagulation, as well as at 1,6, and 12 months after 577-nm PASCAL photocoagulation. Computerized intraretinal segmentation of opticalcoherence tomography was performed to identify the thickness of each retinal layer. Results: The average thickness of the RNFL, ganglion cell layer, inner plexiform layer, inner nuclear layer, innerretinal layer, and CMT at each follow-up increased significantly from baseline (p < 0.001), whereas that of theretinal pigment epithelium at each follow-up decreased significantly from baseline (p < 0.001). The averagethickness of the peripapillary RNFL increased significantly at one month (p < 0.001). This thickness subsequentlyrecovered to 7.48 μm, and there were no significant changes at six or 12 months compared to baseline(p > 0.05). Conclusions: Each macular retinal layer and CMT had a tendency to increase for one year after 577-nm PASCALphotocoagulation, whereas the average thickness of retinal pigment epithelium decreased at one-yearfollow-up compared to the baseline. Although an increase in peripapillary RNFL thickness was observed onemonth after 577-nm PASCAL photocoagulation, there were no significant changes at the one-year follow-upcompared to the baseline.
Abstract
Purpose: The aim of this study was to evaluate the changes in thickness of each macular retinal layer, theperipapillary retinal nerve fiber layer (RNFL), and central macular thickness (CMT) after 577-nm pattern scanninglaser (PASCAL) photocoagulation in patients with diabetic retinopathy. Methods: This retrospective study included 33 eyes with diabetic retinopathy that underwent 577-nm PASCALphotocoagulation. Each retinal layer thickness, peripapillary RNFL thickness, and CMT were measured byspectral-domain optical coherence tomography before 577-nm PASCAL photocoagulation, as well as at 1,6, and 12 months after 577-nm PASCAL photocoagulation. Computerized intraretinal segmentation of opticalcoherence tomography was performed to identify the thickness of each retinal layer. Results: The average thickness of the RNFL, ganglion cell layer, inner plexiform layer, inner nuclear layer, innerretinal layer, and CMT at each follow-up increased significantly from baseline (p < 0.001), whereas that of theretinal pigment epithelium at each follow-up decreased significantly from baseline (p < 0.001). The averagethickness of the peripapillary RNFL increased significantly at one month (p < 0.001). This thickness subsequentlyrecovered to 7.48 μm, and there were no significant changes at six or 12 months compared to baseline(p > 0.05). Conclusions: Each macular retinal layer and CMT had a tendency to increase for one year after 577-nm PASCALphotocoagulation, whereas the average thickness of retinal pigment epithelium decreased at one-yearfollow-up compared to the baseline. Although an increase in peripapillary RNFL thickness was observed onemonth after 577-nm PASCAL photocoagulation, there were no significant changes at the one-year follow-upcompared to the baseline.
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