Comparison of Safety and Efficacy of Botox and Neuronox in the Management of Benign Essential Blepharospasm: A Split-face Study

Abstract

Purpose: To compare the efficacy and safety of Botox and Neuronox in the management of benign essentialblepharospasm (BEB). Methods: We performed a triple-masked, randomized control study to compare Botox and Neuronox in 48 eyesof 24 patients with BEB. All 24 patients randomly received Botox or Neuronox in the periorbital region in amasked, randomized split-face manner, keeping the injection sites and doses uniform. The toxin preparation,injection, and clinical evaluations were done by three independent observers. Objective outcome measuresincluded improvement in the severity of spasm, grading of the functional visual status, changes in palpebralfissure height, lagophthalmos, superficial punctate keratitis and Schirmer’s test at 2 weeks, 6 weeks, and uponconclusion of the effect of the toxin. Subjective outcome measures included duration of the effect and a forcedchoice stating which half of the face was better. Evaluations were performed through clinical measurements,external digital photography, and high-definition videography. Results: The mean duration of relief from spasms was 3.78 months (standard deviation, 1.58 months; range, 1to 6 months). The improvement in the objective parameters like severity of spasm and functional visual statuswas statistically significant at the 2-week and 6-week follow-up visits (p < 0.001). The changes in palpebral fissureheight, lagophthalmos, and superficial punctate keratitis were equally observed in both groups. At 2 and6 weeks, three of 24 (12.5%) and one of 24 (4%) patients, respectively, reported an unequal effect betweenthe two sides of the face, but this difference was not statistically significant. At final follow-up (conclusion of thetoxin effect), patients reported equal effect with no preference for either hemiface. No statistically significantdifferences were found in the comparative analysis between the Neuronox and Botox groups. Conclusions: Neuronox and Botox are comparable in terms of their safety and efficacy in the management of BEB.