코로나바이러스감염증-19 백신 접종 후 발생한 보그트-고야나기-하라다병 1예
Vogt-Koyanagi-Harada Disease after COVID-19 Vaccination
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목적: 코로나바이러스감염증-19 백신 접종 후 발생한 보그트-고야나기-하라다(Vogt-Koyanagi-Harada, VKH)병 1예를 보고하고자한다. 증례요약: 특이 과거력, 안과적 수술력 없던 53세 여환이 COVID-19 백신(Pfizer-BioNTech) 3차 접종 한 달 후부터 시작된 양안의시력저하, 충혈, 안구통증 및 두통을 주소로 내원하였다. 증상 발현 1주일 후 본원 초진 당시 최대교정시력 우안 0.63, 좌안 1.0이었으며 세극등검사상 양안에 전방염증 2+ 소견과 더불어 안저검사 및 빛간섭단층검사상 양안 시신경유두부종, 맥락막 접힘, 다발의 국소적 장액성 망막박리, 형광안저혈관조영술상 양안 후극부 조영제 누출이 관찰되었다. 이에 VKH병 진단하 안약 및 경구 스테로이드제치료를 시작하였고 2개월 후 완전히 호전되었다. 결론: 기저 질환이 없는 환자에서 COVID-19 백신 후에 VKH병이 발생할 수 있고 이러한 부작용에 대한 설명과 적절한 치료가 필요할수 있다.
Abstract
Purpose: To report a case of Vogt-Koyanagi-Harada (VKH) disease after COVID-19 vaccination. Case summary: A 53-year-old female patient with no history of systemic disease or ocular surgery presented with bilateral decreased visual acuity, hyperemia, eye pain, and headache 1 month after COVID-19 vaccination (Pfizer-BioNTech). She initially presented 1 week after symptom onset. Her best-corrected visual acuity was 0.63 in the right eye and 1.0 in the left eye, and she had bilateral grade 2 anterior chamber reactions on slit-lamp examination. Fundus photography, optical coherence tomography, and fluorescein angiography revealed bilateral optic disc swelling, choroidal folds, multiple serous retinal detachments, and fluorescein leakage at posterior poles. She was diagnosed with VKH disease and treated with topical and systemic medications, which completely resolved her symptoms over 2 months. Conclusions: VKH disease can develop after COVID-19 vaccination in patients without any underlying disease. Therefore, possible side effects and treatments should be explained to patients receiving COVID-19 vaccination.
참고문헌 (17)
- O'Keefe GA, "Vogt-Koyanagi-Harada disease", Surv Ophthalmol, 62, pp.1~25 (2017)
- Bolletta E, "Uveitis and other ocular complications following COVID-19 vaccination", J Clin Med, 10, pp.5960~ (2021)
- Joo CW, "Vogt-Koyanagi-Harada disease following mRNA-1273(Moderna)COVID-19 vaccination", Ocul Immunol Inflamm, 30, pp.1250~1254 (2022)
- Ng XL, "Ocular adverse events after COVID-19 vaccination", Ocul Immunol Inflamm, 29, pp.1216~1224 (2021)
- Koong LR, "Vogt-Koyanagi-Harada disease associated with COVID-19 mRNA vaccine", Ocul Immunol Inflamm, 29, pp.1212~1215 (2021)
- De Domingo B, "Vogt-Koyanagi-Harada disease exacerbation associated with COVID-19 vaccine", Cells, 11, pp.1012~ (2022)
- Saraceno JJF, "Vogt-Koyanagi-Harada syndrome following COVID-19 and ChAdOx1 nCoV-19(AZD1222)vaccine", Int J Retina Vitreous, 7, pp.49~ (2021)
- Chen X, "Acute-onset Vogt-Koyanagi-Harada like uveitis following COVID-19 inactivated virus vaccination", Am J Ophthalmol Case Rep, 26, pp.101404~ (2022)
- Yamaguchi C, "De novo Vogt-Koyanagi-Harada disease after vaccination for COVID-19, successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy", Am J Ophthalmol Case Rep, 27, pp.101616~ (2022)
- Yepez JB, "Vogt-Koyanagi-Harada disease following COVID-19 infection", Case Rep Ophthalmol, 12, pp.804~808 (2021)
- Rossella T, "Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases”", Clin Immunol, 224, pp.108665~ (2021)
- Teijaro JR, "COVID-19 vaccines : modes of immune activation and future challenges", Nat Rev Immunol, 21, pp.195~197 (2021)
- Bettini E, "SARS-CoV-2 mRNA vaccines : immunological mechanism and beyond", Vaccines(Basel), 9, pp.147~ (2021)
- Chi W, "IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease", J Allergy Clin Immunol, 119, pp.1218~1224 (2007)
- Hotez PJ, "The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement", Microbes Infect, 22, pp.165~167 (2020)
- Singh RB, "Vaccine-associated uveitis after COVID-19 vaccination : vaccine adverse event reporting system database analysis", Ophthalmology, 130, pp.179~186 (2023)
- Kim KH, "Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations", Mult Scler Relat Disord, 68, pp.104141~ (2022)