Corneal Nerves Alteration Associated with Corneal Complications after Pars Plana Vitrectomy
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Purpose: To evaluate the effect of corneal nerves assessment on predicting corneal complications following pars plana vitrectomy(PPV). Methods: In this prospective single-center cohort study, 94 patients (94 eyes) received PPV, and were divided into postoperativegroups with and without corneal complications. All eyes had corneal nerve fiber length (CNFL), corneal nerve fiberdensity, and branch density of corneal nerve fibers assessed and calculated with Image J preoperatively. Multivariate logisticregression analysis was used to identify corneal nerve fiber parameters that correlated to post-operative corneal complications. Receiver operator characteristic curve analysis was performed to identify the optimal cut-off point of the cornealfibers’ parameters for predicting corneal complications after PPV. Results: Eleven eyes (11.70%) developed corneal complications at 1 week after PPV. There was significant difference betweenCNFL (19.44 ± 6.88 vs. 26.84 ± 7.53, p = 0.003), corneal nerve fiber density (28.82 ± 9.91 vs. 37.10 ± 10.16, p = 0.013) andbranch density of corneal nerve fibers (55.84 ± 21.08 vs. 82.04 ± 31.89, p = 0.01) in two groups, respectively. Receiver operatorcharacteristic analysis showed that the optimal cutoff value of CNFL to predict corneal complications following PPV was<26.495 mm/mm2. Conclusions: The decrease of CNFL may predict corneal complications following PPV. Regular preoperative corneal confocalmicroscopy test in PPV patients could be considered.
Abstract
Purpose: To evaluate the effect of corneal nerves assessment on predicting corneal complications following pars plana vitrectomy(PPV). Methods: In this prospective single-center cohort study, 94 patients (94 eyes) received PPV, and were divided into postoperativegroups with and without corneal complications. All eyes had corneal nerve fiber length (CNFL), corneal nerve fiberdensity, and branch density of corneal nerve fibers assessed and calculated with Image J preoperatively. Multivariate logisticregression analysis was used to identify corneal nerve fiber parameters that correlated to post-operative corneal complications. Receiver operator characteristic curve analysis was performed to identify the optimal cut-off point of the cornealfibers’ parameters for predicting corneal complications after PPV. Results: Eleven eyes (11.70%) developed corneal complications at 1 week after PPV. There was significant difference betweenCNFL (19.44 ± 6.88 vs. 26.84 ± 7.53, p = 0.003), corneal nerve fiber density (28.82 ± 9.91 vs. 37.10 ± 10.16, p = 0.013) andbranch density of corneal nerve fibers (55.84 ± 21.08 vs. 82.04 ± 31.89, p = 0.01) in two groups, respectively. Receiver operatorcharacteristic analysis showed that the optimal cutoff value of CNFL to predict corneal complications following PPV was<26.495 mm/mm2. Conclusions: The decrease of CNFL may predict corneal complications following PPV. Regular preoperative corneal confocalmicroscopy test in PPV patients could be considered.
참고문헌 (19)
- Chen HF, "Persistent corneal epithelial defect after pars plana vitrectomy", Retina, 36, pp.148~155 (2016)
- Chen WL, "In vivo confocal microscopic findings of corneal wound healing after corneal epithelial debridement in diabetic vitrectomy", Ophthalmology, 116, pp.1038~1047 (2009)
- Chiang WY, "Factors associated with corneal epithelial defects after pars plana vitrectomy", Int Ophthalmol, 38, pp.105~110 (2018)
- Kalteniece A, "Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities", PLoS One, 12, pp.e0183040~ (2017)
- Hiraoka M, "Factors contributing to corneal complications after vitrectomy in diabetic patients", Jpn J Ophthalmol, 45, pp.492~495 (2001)
- Tsubota K, "Treatment of persistent corneal epithelial defect by autologous serum application", Ophthalmology, 106, pp.1984~1989 (1999)
- Vagenas D, "Optimal image sample size for corneal nerve morphometry", Optom Vis Sci, 89, pp.812~817 (2021)
- Kallinikos P, "Corneal nerve tortuosity in diabetic patients with neuropathy", Invest Ophthalmol Vis Sci, 45, pp.418~422 (2004)
- Malik RA, "Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients", Diabetologia, 46, pp.683~688 (2003)
- Al-Hinai AS, "Corneal epithelial defect after pars plana vitrectomy", Oman J Ophthalmol, 10, pp.162~166 (2017)
- Al-Aqaba MA, "Ex vivo confocal microscopy of human corneal nerves", Br J Ophthalmol, 94, pp.1251~1257 (2010)
- Nielsen NV, "Diabetic polyneuropathy: corneal sensitivity, vibratory perception and Achilles tendon reflex in diabetics", Acta Neurol Scand, 59, pp.15~22 (1979)
- Al-Aqaba MA, "Corneal nerves in health and disease", Prog Retin Eye Res, 73, pp.100762~ (2019)
- Baker KS, "Trigeminal ganglion neurons affect corneal epithelial phenotype:influence on type VII collagen expression in vitro", Invest Ophthalmol Vis Sci, 34, pp.137~144 (1993)
- Bikbova G, "Diabetic corneal neuropathy:clinical perspectives", Clin Ophthalmol, 12, pp.981~987 (2018)
- Hossain P, "Early detection of diabetic peripheral neuropathy with corneal confocal microscopy", Lancet, 366, pp.1340~1343 (2005)
- Midena E, "Corneal diabetic neuropathy: a confocal microscopy study", J Refract Surg, 22(9 Suppl), pp.S1047~S1052 (2006)
- Priyadarsini S, "Diabetic keratopathy:insights and challenges", Surv Ophthalmol, 65, pp.513~529 (2020)
- Scarr D, "Agreement between automated and manual quantification of corneal nerve fiber length: implications for diabetic neuropathy research", J Diabetes Complications, 31, pp.1066~1073 (2017)