Long-term Effects of Uncomplicated Traumatic Hyphema on Corneal and Lenticular Clarity
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: To evaluate the long-term effects of uncomplicated traumatic hyphema on endothelial morphology, anterior segmentstructure, and corneal and lenticular densitometryMethods: In this retrospective comparative study, eyes with a history of uncomplicated traumatic hyphema were comparedwith the healthy contralateral unaffected eyes. The corneal endothelial cell properties were captured using specular microscopy. Anterior segment analysis, corneal densitometry (12-mm corneal diameter), and lens densitometry measurements wereperformed using the Pentacam imaging system. Results: Measurements were obtained at a mean follow-up of 49.5 ± 15.8 months after injury. The average endothelial celldensity was significantly lower in the study group than in the control group (2,506.6 ± 294.0 cells/mm² vs. 2,665.7 ± 195.0cells/mm², p = 0.020). There was no difference between the groups in respect of polymegathism and pleomorphism (p = 0.061and p = 0.558, respectively). All the investigated corneal tomographic and angle parameters were similar in both groups (allp > 0.05). The corneal densitometry values in all concentric zones and layers showed no statistically significant difference betweenthe groups (p > 0.05 for all). The lens zone 1 densitometry value was significantly higher in the study group than in thecontrol group (9.6% ± 1.1% vs. 8.9% ± 1.2%, p = 0.031). No difference was observed in zone 2 and 3 (p = 0.170 and p = 0.322,respectively). The degree of hyphema was not correlated with endothelial cell and lenticular clarity loss (p = 0.087 andp = 0.294, respectively). Conclusions: Even if traumatic hyphema is not complicated, long-term outcomes indicate endothelial cell loss and increasedlenticular density.
Abstract
Purpose: To evaluate the long-term effects of uncomplicated traumatic hyphema on endothelial morphology, anterior segmentstructure, and corneal and lenticular densitometryMethods: In this retrospective comparative study, eyes with a history of uncomplicated traumatic hyphema were comparedwith the healthy contralateral unaffected eyes. The corneal endothelial cell properties were captured using specular microscopy. Anterior segment analysis, corneal densitometry (12-mm corneal diameter), and lens densitometry measurements wereperformed using the Pentacam imaging system. Results: Measurements were obtained at a mean follow-up of 49.5 ± 15.8 months after injury. The average endothelial celldensity was significantly lower in the study group than in the control group (2,506.6 ± 294.0 cells/mm² vs. 2,665.7 ± 195.0cells/mm², p = 0.020). There was no difference between the groups in respect of polymegathism and pleomorphism (p = 0.061and p = 0.558, respectively). All the investigated corneal tomographic and angle parameters were similar in both groups (allp > 0.05). The corneal densitometry values in all concentric zones and layers showed no statistically significant difference betweenthe groups (p > 0.05 for all). The lens zone 1 densitometry value was significantly higher in the study group than in thecontrol group (9.6% ± 1.1% vs. 8.9% ± 1.2%, p = 0.031). No difference was observed in zone 2 and 3 (p = 0.170 and p = 0.322,respectively). The degree of hyphema was not correlated with endothelial cell and lenticular clarity loss (p = 0.087 andp = 0.294, respectively). Conclusions: Even if traumatic hyphema is not complicated, long-term outcomes indicate endothelial cell loss and increasedlenticular density.
참고문헌 (28)
- Wilson FM, "Traumatic hyphema : pathogenesis and management", Ophthalmology, 87, pp.910~919 (1980)
- Walton W, "Management of traumatic hyphema", Surv Ophthalmol, 47, pp.297~334 (2002)
- Pass AF, "Ocular therapeutics handbook: a clinical manual", pp.329~334 (1998), Lippincott Williams & Wilkins
- Lenihan P, "Traumatic hyphema : a teaching case report", Optom Educ, 39, pp.110~118 (2014)
- Slingsby JG, "Effect of blunt trauma on the corneal endothelium", Arch Ophthalmol, 99, pp.1041~1043 (1981)
- 이현덕, "외상성 전방출혈 환자에서 각막내피세포의 변화 외상성 전방출혈", 대한안과학회지, 43(9), pp.25~1737 (2002), 대한안과학회
- Brooks AM, "The identification of different vascular cells on the corneal endothelium by specular microscopy. I. Red blood cells and corneal endothelial changes in hyphaema secondary to contusion injury", Aust N Z J Ophthalmol, 16, pp.3~6 (1988)
- Pong J, "Effect on corneal endothelial cell count of traumatic microhyphaema and hyphaema", Acta Ophthalmol, 87, pp.559~561 (2009)
- Kiziltoprak H, "Evaluation of densitometric analysis for early detection of corneal blood staining in hyphema", Cornea, 40, pp.467~471 (2021)
- Edwards WC, "Traumatic hyphema : a report of 184 consecutive cases", Am J Ophthalmol, 75, pp.110~116 (1973)
- McCarey BE, "Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions", Cornea, 27, pp.1~16 (2008)
- Lopes B, "Corneal densitometry in keratoconus", Cornea, 33, pp.1282~1286 (2014)
- Messmer EP, "Blood staining of the cornea:a histopathologic analysis of 16 cases", Cornea, 3, pp.205~212 (1985)
- McDonnell PJ, "Blood staining of the cornea : light microscopic and ultrastructural features", Ophthalmology, 92, pp.1668~1674 (1985)
- Chaurasia S, "Specular microscopy in clinical practice", Indian J Ophthalmol, 69, pp.517~524 (2021)
- Otri AM, "Corneal densitometry as an indicator of corneal health", Ophthalmology, 119, pp.501~508 (2012)
- Jester JV, "The cellular basis of corneal transparency: evidence for ‘corneal crystallins’", J Cell Sci, 112(Pt 5), pp.613~622 (1999)
- Meek KM, "Corneal collagen-its role in maintaining corneal shape and transparency", Biophys Rev, 1, pp.83~93 (2009)
- Ma J, "Biomechanics and structure of the cornea : implications and association with corneal disorders", Surv Ophthalmol, 63, pp.851~861 (2018)
- Enders P, "Corneal densitometry for quantification of corneal deposits in monoclonal gammopathies", Cornea, 36, pp.470~475 (2017)
- Edelhauser HF, "The balance between corneal transparency and edema: the Proctor Lecture", Invest Ophthalmol Vis Sci, 47, pp.1754~1767 (2006)
- Bourne WM, "Corneal endothelium: past, present, and future", Eye Contact Lens, 36, pp.310~314 (2010)
- Churchill AJ, "Factors affecting visual outcome in children following uniocular traumatic cataract", Eye(Lond), 9(Pt 3), pp.285~291 (1995)
- Khatry SK, "The epidemiology of ocular trauma in rural Nepal", Br J Ophthalmol, 88, pp.456~460 (2004)
- Sinha R, "Etiopathogenesis of cataract : journal review", Indian J Ophthalmol, 57, pp.245~249 (2009)
- Gupta VB, "Etiopathogenesis of cataract : an appraisal", Indian J Ophthalmol, 62, pp.103~110 (2014)
- Gagnon MM, "Corneal endothelial cell density in glaucoma", Cornea, 16, pp.314~318 (1997)
- Yu ZY, "Changes in corneal endothelial cell density in patients with primary open-angle glaucoma", World J Clin Cases, 7, pp.1978~1985 (2019)