허리 척추원반탈출증 시 탈출된 척추원반의 조직학적 구성
Histological Composition of the Extruded Intervertebral Disc in Lumbar Intervertebral Disc Herniation
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허리 척추원반탈출증 환자의 탈출된 척추원반에서 섬유테, 연골종판 및 속질핵의 비율을 파악하기 위하 여 수술에서 확보된 탈출된 척추원반의 조직학적 구성 비율을 확인하였다. 31명의 척추원반탈출증 환자로부터 적출된 척추원반에 대해 H-E 염색을 시행하였다. 염색된 조직은 현미경절편 사진을 만든 후 속질핵, 연골종판 및 속질핵의 비율을 현미경을 보면서 구분하여 사진에 표시한 다음 이들의 조직 학적 구성을 비교분석하였다. 본 연구결과 탈출된 척추원반의 구성성분은 평균 속질핵이 50.7%, 섬유테가 41.3% 및 연골종판이 8.0%이었다. 탈출된 척추원반의 연골종판 비율이 여자가 남자보다 높은 경향을 보였으며, 탈출된 척추원반에서 속질핵이 차지 하는 비율이 나이가 들어감에 따라 감소하는 경향은 보였으나 통계적 유의성은 없었다. 이러한 결과는 척추원반탈출증 환자의 통증을 비롯한 임상양상을 파악하고 접근하는데 기본적인 자료를 제공 할 것이다.
Abstract
The aim of this study was to investigate histological composition (ratio of anulus fibrosus, cartilage endplate, and nucleus pulposus) of the herniated lumbar intervertebral disc fragments. The relative percentage of anulus fibrosus, cartilage endplate, and nucleus pulposus was examined in the herniated interverterbral disc fragments. The herniated intervertebral discs took out from the 31 patients were stained with H-E. The stained tissues were photographed, and the histological composition of the herniated intervertebral discs was analyzed after marking 3 components on the photograph with microscopic observation. The composition of the herniated lumbar intervertebral disc is 50.7% of nucleus pulposus, 41.3% of anulus fibrosus, and 8.0% of cartilage endplate. The proportion of the endplate in the herniated intervertebral disc in male was tend to be higher than that in female, and the proportion of the nucleus pulposus was tend to be decreased with aging, however, fail to reach statistical significance. This result may provide fundamental information for accessing clinical symptoms including pain in lumbar vertebral disc herniation.
참고문헌 (25)
- "Measuring the functional status of patients with low back pain", 20, pp.1017~1028 (1995)
- "The form and structure of theextruded disc. Spine 17", pp.1457~1461 (1992)
- "A model for chronic nerve root compression studies.", 22, pp.946~957 (1997)
- "Epidemiologic studies of low-back pain.Spine 5", pp.419~423 (1980)
- "Diagnostic utility of the McGill PainQuestionnaire and the Oswestry Disability Questionnairefor classification of low back pain syndromes. J ManipulativePhysiol Ther 15", pp.90~98 (1992)
- "A pathologic study of lumbar discherniation in the elderly. Spine 14", pp.1020~1024 (1989)
- "Injuries to the human spinal column", pp.297~352 (1981)
- "The effects of induced hypertension and acutegraded compression on impulse propagation in the spinalnerve roots of the pig. Spine 18", pp.1550~1555 (1993), Lincoln T
- "Metaplastic proliferative fibrocartilage as an alternativeconcept to herniated intervertebral disc. Spine 3", pp.1055~1060 (1988)
- "The use of the percentage changein Oswestry Disability Index score as an outcome measurein lumbar spinal surgery. Spine 19", pp.2139~2143 (1994)
- "Do bending, twisting, and diurnal fluid changes in the disc affect the propensity to prolapse?", 21, pp.2570~2579 (1996)
- "Investigation of the relation between low backpain and occupation. VII. Neurologic and orthopedic condition.Scand J Rehabil Med 7", pp.146~151 (1975)
- "The McGill pain questionnaire: from description to measurement.", 103, pp.199~202 (2005)
- "Clinically oriented anatomy", pp.432~450 (1999), Lippincott Williams & Wilkins
- "The origin and fate of herniated lumbar intervertebral disc tissue.", 21, pp.2149~2155 (1996)
- "Experimentalnerve root compression. A model of acute gradedcompression of the porcine cauda equina and an analysis ofneural and vascular anatomy. Spine 16", pp.61~69 (1991)
- "Effects of experimentalgraded compression on blood flow in spinal nerveroots. A vital microscopic study on the porcine cauda equina.J Orthop Res 7", pp.817~823 (1989)
- "Observations on the postnatal structure of theintervertebral disc in man. J Anat 86", pp.162~179 (1952)
- "Effects of magnitude andduration of compression on spinal nerve root conduction. Spine 17"
- "Pathoanatomy andpathophysiology of nerve root compression. Spine 9", pp.7~15 (1984)
- "Long-term prognosis of renovascular hypertension comparative study in operated and non-operated patients.Jpn Circ J 39", pp.767~773 (1975)
- "The contribution of theintervertebral disk to the scoliotic deformity. Clin OrthopRelat Res 156", pp.79~90 (1981)
- "Clinical symptoms in lumbar disc herniations and theircorrelation to the histological composition of the extrudeddisc material.", 29, pp.1655~1661 (2004)
- "The histology of lumbarintervertebral disc herniation. The significance of smallblood vessels in the extruded tissue. Spine 18", pp.1761~1765 (1993)
- "Histologicalchanges in aging lumbar intervertebral discs. Their role inprotrusions and prolapses. J Bone Joint Surg Am 72", pp.220~229 (1990)