IL-17 조절을 통한 천식의 치료: Phosphoinositide 3-Kinase와 Peroxisome Proliferator-Activated Receptor Activator γ

참고문헌 (56)

1. Bousquet J, "Asthma. From bronchoconstriction to airways inflammation and remodeling", Am J Respir Crit Care Med, 161, pp.1720~1745 (2000)
2. Adcock IM, "New targets for drug development in asthma", Lancet, 372, pp.1073~1087 (2008)
3. Holgate ST, "Treatment strategies for allergy and asthma", Nat Rev Immunol, 8, pp.218~230 (2008)
4. Mosmann TR, "Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins", J Immunol, 136, pp.2348~2357 (1986)
5. Harrington LE, "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages", Nat Immunol, 6, pp.1123~1132 (2005)
6. Miossec P, "Interleukin-17 and type 17 helper T cells", N Engl J Med, 361, pp.888~898 (2009)
7. Kim SR, "PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease", J Immunol, 179, pp.6820~6829 (2007)
8. Park SJ, "Peroxisome proliferator-activated receptor gamma agonist down- regulates IL-17 expression in a murine model of allergic airway inflammation", J Immunol, 183, pp.3259~3267 (2009)
9. Pappu BP, "Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines", Pharmacol Ther, 117, pp.374~384 (2008)
10. Witowski J, "Interleukin-17: a mediator of inflammatory responses", Cell Mol Life Sci, 61, pp.567~579 (2004)
11. Kawaguchi M, "Modulation of bronchial epithelial cells by IL-17", J Allergy Clin Immunol, 108, pp.804~809 (2001)
12. Park H, "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17", Nat Immunol, 6, pp.1133~1141 (2005)
13. Wang YH, "The IL-17 cytokine family and their role in allergic inflammation", Curr Opin Immunol, 20, pp.697~702 (2008)
14. Chen Y, "Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine", autocrine loop, 2003, pp.278, 17036~17043
15. Honorati MC, "IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes", Osteoarthritis Cartilage, 12, pp.683~691 (2004)
16. Kolls JK, "Interleukin-17 family members and inflammation", Immunity, 21, pp.467~476 (2004)
17. Schwarzenberger P, "IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines", J Immunol, 161, pp.6383~6389 (1998)
18. Laan M, "Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways", J Immunol, 162, pp.2347~2352 (1999)
19. Huang F, "Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4", IL-13: important implications in asthma, 2008, pp.121, 1415~1421
20. Jatakanon A, "Neutrophilic inflammation in severe persistent asthma", Am J Respir Crit Care Med, 160, pp.1532~1539 (1999)
21. Hellings PW, "Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma", Am J Respir Cell Mol Biol, 28, pp.42~50 (2003)
22. Schnyder-Candrian S, "Interleukin-17 is a negative regulator of established allergic asthma", J Exp Med, 203, pp.2715~2725 (2006)
23. Molet S, "IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines", J Allergy Clin Immunol, 108, pp.430~438 (2001)
24. Chakir J, "Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression", J Allergy Clin Immunol, 111, pp.1293~1298 (2003)
25. Wong CK, "Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-γ, IL-4, IL-10 and IL-13) in patients with allergic asthma", Clin Exp Immunol, 125, pp.177~183 (2001)
26. Sun YC, "Sputum interleukin-17 is increased and associated with airway neutrophilia in patients with severe asthma", Chin Med J, 118, pp.953~956 (2005)
27. Bullens DM, "IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?", Respir Res, 7, pp.135~ (2006)
28. Barczyk A, "Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine", Respir Med, 97, pp.726~733 (2003)
29. Oboki K, "Th17 and allergy", Allergol Int, 57, pp.121~134 (2008)
30. Fruman DA, "Phosphoinositide 3-kinase in immunological systems", Semin Immunol, 14, pp.7~18 (2002)
31. Koyasu S, "The role of PI3K in immune cells", Nat Immunol, 4, pp.313~319 (2003)
32. Gadina M, "The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common γ chain-uring cytokines", J Biol Chem, 275, pp.26959~26966 (2000)
33. Park SJ, "Phosphoinositide 3-kinase delta inhibitor as a novel therapeutic agent in asthma", Respirology, 13, pp.764~771 (2008)
34. Kwak YG, "Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma", J Clin Investig, 111, pp.1083~1092 (2003)
35. Lee KS, "Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation", Mol Pharmacol, 69, pp.1829~1839 (2006)
36. Duan W, "An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model", Int Immunopharmacol, 5, pp.495~502 (2005)
37. Lee KS, "Inhibition of VEGF blocks TGF-beta1 production through a PI3K", Akt signalling pathway, 2008, pp.31, 523~531
38. Kim KW, "Increased interleukin-17 production via a phosphoinositide 3-kinase", Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis, 2005, pp.7, R139~R148
39. Cho ML, "STAT3 and NF-kappaB signaling pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice", J Immunol, 176, pp.5652~5661 (2006)
40. Cho ML, "Cyclosporine A inhibits IL-15-induced IL-17 production in CD4+ T cells via down-regulation of PI3K", Akt and NF-kappaB, 2007, pp.108, 88~96
41. Huang F, "Requirement for both JAK-mediated PI3K signaling and ACT1", TRAF6, J Immunol, pp.2007, 179[DOI]
42. Wuyts WA, "Interleukin-17--induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappaB", J Heart Lung Transplant, 24, pp.875~881 (2005)
43. Blanquart C, "Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation", J Steroid Biochem Mol Biol, 85, pp.267~273 (2003)
44. Park SJ, "Peroxisome proliferator-activated receptor gamma as a novel therapeutic target in asthma", J Asthma, 45, pp.1~8 (2008)
45. Na HK, "Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation", Biochem Pharmacol, 66, pp.1381~3191 (2003)
46. Gelman L, "An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer", Cell Mol Life Sci, 55, pp.932~943 (1999)
47. Lee KS, "PPAR-gamma modulates allergic inflammation through up- regulation of PTEN", FASEB J, 19, pp.1033~1035 (2005)
48. Kim SR, "Involvement of IL-10 in peroxisome proliferator-activated receptor gamma-mediated anti-inflammatory response in asthma", Mol Pharmacol, 68, pp.1568~1565 (2005)
49. Lee KS, "PPARγ modulates reactive oxygen species generation and activation of NF-κB and HIF-1α in allergic airway disease of mice", J Allergy Clin Immunol, 118, pp.120~127 (2006)
50. Wang AC, "Peroxisome proliferator- activated receptor-gamma regulates airway epithelial cell activation", Am J Respir Cell Mol Biol, 24, pp.688~693 (2001)
51. Woerly G, "Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation", J Exp Med, 198, pp.411~421 (2003)
52. Honda K, "Peroxisome proliferator-activated receptor gamma is expressed in airways and inhibits features of airway remodeling in a mouse asthma model", J Allergy Clin Immunol, 113, pp.882~888 (2004)
53. Trifilieff A, "PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect", Br J Pharmacol, 139, pp.163~171 (2003)
54. Kostadinova R, "PPARs in diseases: control mechanisms of inflammation", Curr Med Chem, 12, pp.2995~3009 (2005)
55. Patel L, "Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN", Curr Biol, 11, pp.764~78 (2001)
56. Lytle C, "The peroxisome proliferator-activated receptor gamma ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency", Inflamm Bowel Dis, 11, pp.231~243 (2005)

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