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천식에서 IL-4/IL-13 사이토카인 및 수용체

IL-4/IL-13 Cytokine and Receptor in Asthma

양은석
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2005.03|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제15권 제1호|pp. 1-11

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참고문헌

주제분류소아과학

초록

Abstract

Asthma is a chronic allergic inflammatory disease of lung. The initiation and progression of asthma is dependent on the cytokines interleukin(IL)-4 and IL-13 acting through related receptor complexes. Disease pathogenesis is effected by intracellular signaling pathways that couple primarily to specific motifs within the intracellular domain of the IL-4 receptor α chain(IL-4Rα), a subunit that is common to the IL-4 and IL-13 receptor complexes. Neutralizing anti-cytokine strategies have proven to be highly successful on dissecting relevant effector pathways in experimental allergic disease, and are now entering clinical trials in human allergic disorders. Although there have been only a few clinical studies on the effects of cytokine modulators in asthma, this line of research and development appears promising.

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