제주 소아 및 청소년의 아토피 및 흡입 알레르기항원에 대한 감작률
Atopy and Sensitization Rates to Aeroallergens in Children and Teenagers in Jeju, Korea
2
조회
0
다운로드
25
인용
0
참고문헌
키워드
초록
Background: Atopic sensitization to aeroallergens is an essential preceding factor for atopic disorders. The information on the sensitization rates and their changes is an important tool to cope with increasing atopic disorders; however, it is rarely available in Korea. Objective: We investigated the prevalence of atopy, the sensitization rates to common aeroallergens and their recent changes. Method: With informed consent, skin prick tests were performed on the study population. Atopy was defined as that one or more positive skin prick test responses (wheal, ≥3 mm) to the 16 common aeroallergens. The prevalence of atopy and the sensitization rates to each allergen were compared with those of previous reports. Result: Approximately 7% (1,343, mean age of 13 years) of school children in Jeju were enrolled. Skin tests to the 16 aeroallergens were performed on 1,060 subjects (83%). The prevalence of atopy was 51.9%. House dust mites (HDM), Japanese cedar, Tyrophagus putrescentiae and citrus red mites were frequently sensitized aeroallergens. Comparing with previous reports, the prevalence of atopy and the sensitization rates of HDM, cedar and outdoor moulds were higher. Conclusion: Atopy among school children in Jeju is increasing. HDM, Japanese cedar and outdoor moulds are the important aeroallergens which are increasing recently. The increase of atopic disorder may be related to the change of living environment.
Abstract
Background: Atopic sensitization to aeroallergens is an essential preceding factor for atopic disorders. The information on the sensitization rates and their changes is an important tool to cope with increasing atopic disorders; however, it is rarely available in Korea. Objective: We investigated the prevalence of atopy, the sensitization rates to common aeroallergens and their recent changes. Method: With informed consent, skin prick tests were performed on the study population. Atopy was defined as that one or more positive skin prick test responses (wheal, ≥3 mm) to the 16 common aeroallergens. The prevalence of atopy and the sensitization rates to each allergen were compared with those of previous reports. Result: Approximately 7% (1,343, mean age of 13 years) of school children in Jeju were enrolled. Skin tests to the 16 aeroallergens were performed on 1,060 subjects (83%). The prevalence of atopy was 51.9%. House dust mites (HDM), Japanese cedar, Tyrophagus putrescentiae and citrus red mites were frequently sensitized aeroallergens. Comparing with previous reports, the prevalence of atopy and the sensitization rates of HDM, cedar and outdoor moulds were higher. Conclusion: Atopy among school children in Jeju is increasing. HDM, Japanese cedar and outdoor moulds are the important aeroallergens which are increasing recently. The increase of atopic disorder may be related to the change of living environment.
참고문헌 (28)
- Adkinson NF, "vivo methods for study of allergy: skin tests, techniques, and interpretation", pp.631~43 (2005), Mosby
- Wood RA, "A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy", J Allergy Clin Immunol, 103, pp.773~9 (1999)
- Hong CS, "Allergic skin test and reading method", J Asthma Allergy Clin Immunol, 13, pp.23~32 (1993)
- Beasley R, "Prevalence and etiology of asthma", J Allergy Clin Immunol, 105, pp.466~72 (2000)
- Lee HL, "Survey on allergic diseases in children", J Korean Med Assoc, 26, pp.254~62 (1983)
- Korean Academy of Pediatric Allergy and Respiratory Diseases, "Prevalences of allergic diseases in Korean children; a nationwide questionnaire survey: asthma. Committee of The Korean Academy of Pediatric Allergy and Respiratory Disease for Epidemiologic Study", Pediatr Allergy Respir Dis, 12, pp.S49~53 (2002)
- Lee SI, "Prevalences of symptoms of asthma and other allergic disease in Korean children; A nationwide questionnaire survey", J Korean Med Sci, 16, pp.155~64 (2001)
- Gergen PJ, "The prevalence of allergic skin tests reactivity to eight common aeroallergens in the U.S. population: results from the second National Health and Nutrition Examination Survey", J Allergy Clin Immunol, 80, pp.669~79 (1987)
- Kim MK, "Change of causative inhalant allergens in respiratory allergic patients in Chungbuk district", J Asthma Allergy Clin Immunol, 19, pp.696~702 (1999)
- 이재영, "대전지역의 알레르기 크리닉을 방문한 환자에서 긴털가루진드기(Tyrophagus putrescentiae)의 감작률", 천식 및 알레르기, 22(4), pp.703~710 (2002), 대한천식알레르기학회
- Ko YH, "A clinical statistics on the offending allergens of allergic rhinitis", Korean J Otolaryngol, 41, pp.42~7 (1998)
- 김태범, "흡입 알레르겐에 대한 감작율: 다기관 공동연구", 천식 및 알레르기, 23(3), pp.483~493 (2003), 대한천식알레르기학회
- 이명현, "Prevalence of atopic rhinitis and causative allergens in children living in rural area of Cheju island", 천식 및 알레르기, 21, pp.198~204 (2001)
- Min KU, "Prevalence of allergic rhinitis and its causative allergens in people in rural area of Cheju island", J Asthma Allergy Clin Immunol, 19, pp.42~9 (1999)
- [URL]
- Kim WK, "Recent increase of atopy prevalence in Seoul: 1990~1994", Korean J Asthma Allergy Clin Immunol, 15, pp.304~10 (1995)
- Gortmaker SL, "Television viewing as a cause of increasing obesity among children in the United States, 1986-1990", Arch Pediatr Adolesc Med, 150, pp.356~62 (1996)
- Park HS, "Cat-induced respiratory allergy: Relationship between cat allergen and commercial extracts of house dust", Korean J Asthma Allergy Clin Immunol, 9, pp.10~9 (1989)
- Nahm DH, "Seasonal variation of skin reactivity and specific IgE antibody to house dust mites", Ann Allergy Asthma Immunol, 78, pp.589~93 (1997)
- Kaneko Y, "Eboshida A. Increasing prevalence of Japanese cedar pollinosis: a meta- regression analysis", Int Arch Allergy Immunol, 136, pp.365~71 (2005)
- 김경호, "부산지역 호흡기 알레르기 환자에서 흡입 알레르겐에 대한 감작률", 천식 및 알레르기, 25(1), pp.59~63 (2005), 대한천식알레르기학회
- Min KU, "Study of Japanese cedar pollen in Cheju island", J Asthma Allergy Clin Immunol, 16, pp.308~14 (1996)
- Kim YY, "Genetic and enviromental factors and intrinsic asthma, In Progress in allergy and clinical immunology. 4th ed", pp.219~22 (1997), Hogrefe & Huber
- Lee H, "Sensitization rates to inhalent allergens in atopic individuals in Jeju, Korea", J Med Life Sci, 6, pp.119~25 (2009)
- Shea KM, "Climate change and allergic disease", J Allergy Clin Immunol, 122, pp.443~53 (2008)
- "Korea Meteorological Administration data"[URL]
- Moriguchi H, "The development of a pollen information system for the improvement of QOL", J Med Invest, 42, pp.198~209 (2001)
- Nishiike S, "Measurement of quality of life during different clinical phases of Japanese cedar pollinosis", Auris Nasus Larynx, 31, pp.135~9 (2004)