벌독 아나필락시스 환자에서 과거 벌자상 알레르기반응 병력과 특이 IgE 항체 검사 결과의 분석
Clinical Significance of Past History on the Preceding Reaction to Bee Sting and Specific IgE Antibody to Bee Venom in Patients with Bee Sting Anaphylaxis
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Background: Severity of allergic reactions to bee venoms may depend on the degree of previous sting reactions. Tests for venom-specific IgE antibodies are frequently positive in patients with allergic sting reactions. Objective: We studied the clinical significance of preceding reactions and serum-specific IgE antibodies in patients with bee sting anaphylaxis. Method: Nine patients with bee sting anaphylaxis were included. Details in the current anaphylaxis and previous reactions were retrospectively obtained. Venom-specific IgE antibodies were measured by using ImmunoCAP in 6patients. Result: Seven (78%) of 9 patients had preceding reactions. Details in the reactions were available in 5 patients who were stung by the same bee or family as the current stings. Four (80%) patients of these 5 patients had experienced only large local reactions or systemic cutaneous reactions from the preceding stings. With regard to specific IgE antibodies,2 (33%) of the 6 patients were negative for the same venoms as in the preceding stings. Conclusion: Bee venom-induced anaphylaxis can occur although preceding reactions are local or mild systemic ones. Tests for venom-specific IgE antibodies can be negative in patients with bee sting anaphylaxis.
Abstract
Background: Severity of allergic reactions to bee venoms may depend on the degree of previous sting reactions. Tests for venom-specific IgE antibodies are frequently positive in patients with allergic sting reactions. Objective: We studied the clinical significance of preceding reactions and serum-specific IgE antibodies in patients with bee sting anaphylaxis. Method: Nine patients with bee sting anaphylaxis were included. Details in the current anaphylaxis and previous reactions were retrospectively obtained. Venom-specific IgE antibodies were measured by using ImmunoCAP in 6patients. Result: Seven (78%) of 9 patients had preceding reactions. Details in the reactions were available in 5 patients who were stung by the same bee or family as the current stings. Four (80%) patients of these 5 patients had experienced only large local reactions or systemic cutaneous reactions from the preceding stings. With regard to specific IgE antibodies,2 (33%) of the 6 patients were negative for the same venoms as in the preceding stings. Conclusion: Bee venom-induced anaphylaxis can occur although preceding reactions are local or mild systemic ones. Tests for venom-specific IgE antibodies can be negative in patients with bee sting anaphylaxis.
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