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논문KCI 등재

국내 성인 아나필락시스 원인의 계절 및 지역 분포

Seasonal and regional variations in the causes of anaphylaxis in Korean adults

김철우|김주희|김미경|손성욱|박혜경|강혜련|김상헌|김태범|장광천|이수걸|최길순|박해심|고영일|지영구|예영민|허규영|대한천식알레르기학회|이연경
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2015.05|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제3권 제3호|pp. 187-193

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키워드

AdultEtiologySeasonsAnaphylaxisGeographic locations
주제분류소아과학

초록

Purpose: To investigate whether causes of anaphylaxis vary according to regions and seasons in Korean adults. Methods: Based on previous retrospective studies of anaphylaxis between 2007 and 2011 at the 15 university hospitals. Regions were classified into 4 groups: region I, Seoul; region II, Gyeonggi; region III, Chungcheong; and region IV, Chonnam and Busan. The cases induced by 5 major allergens including drugs, food, bee sting, radiocontrast media, and exercise, were analyzed in the present study. Results: Among a total of 1,661 cases reported (53% male, 45.9±16.0 years), 367 (22.2%), 706 (42.5%), 319 (19.2%), and 269 cases (16.2%) were enrolled in regions I, II, III, and IV, respectively. Of the 5 major allergens, drugs (37.3%) were the most frequently reported, followed by food (25.7%), bee sting (17.9%), radiocontrast media (12.9%), and exercise (6.2%). There was no significant difference in the total occurrence of anaphylaxis in 4 seasons (374 in spring, 460 in summer, 460 in autumn, and 367 in winter). Multiple logistic regression analysis revealed that drug-induced anaphylaxis was significantly associated with the winter season (odds ratio [OR] 1.0 vs. OR 0.597, P<0.05 for spring; OR 1.0 vs. OR 0.481, P<0.01 for summer; OR 1.0 vs. OR 0.653, P<0.05 for autumn). Food-associated anaphylaxis was mainly reported in region I, whereas the frequency of insect sting was relatively higher in regions II, III, and IV than in region I. Older age and female gender were significantly associated with drug-induced anaphylaxis. Conclusion: Specific causative allergens of anaphylaxis in adults may vary according to age, gender, region, and season in Korea.

Abstract

Purpose: To investigate whether causes of anaphylaxis vary according to regions and seasons in Korean adults. Methods: Based on previous retrospective studies of anaphylaxis between 2007 and 2011 at the 15 university hospitals. Regions were classified into 4 groups: region I, Seoul; region II, Gyeonggi; region III, Chungcheong; and region IV, Chonnam and Busan. The cases induced by 5 major allergens including drugs, food, bee sting, radiocontrast media, and exercise, were analyzed in the present study. Results: Among a total of 1,661 cases reported (53% male, 45.9±16.0 years), 367 (22.2%), 706 (42.5%), 319 (19.2%), and 269 cases (16.2%) were enrolled in regions I, II, III, and IV, respectively. Of the 5 major allergens, drugs (37.3%) were the most frequently reported, followed by food (25.7%), bee sting (17.9%), radiocontrast media (12.9%), and exercise (6.2%). There was no significant difference in the total occurrence of anaphylaxis in 4 seasons (374 in spring, 460 in summer, 460 in autumn, and 367 in winter). Multiple logistic regression analysis revealed that drug-induced anaphylaxis was significantly associated with the winter season (odds ratio [OR] 1.0 vs. OR 0.597, P<0.05 for spring; OR 1.0 vs. OR 0.481, P<0.01 for summer; OR 1.0 vs. OR 0.653, P<0.05 for autumn). Food-associated anaphylaxis was mainly reported in region I, whereas the frequency of insect sting was relatively higher in regions II, III, and IV than in region I. Older age and female gender were significantly associated with drug-induced anaphylaxis. Conclusion: Specific causative allergens of anaphylaxis in adults may vary according to age, gender, region, and season in Korea.

참고문헌 (23)

  1. Simons FE, "World allergy organization guidelines for the assessment and management of anaphylaxis", World Allergy Organ J, 4, pp.13~37 (2011)
  2. Simons FE, "Anaphylaxis", J Allergy Clin Immunol, 125(2 Suppl 2), pp.S161~S181 (2010)
  3. Ben-Shoshan M, "Anaphylaxis: past, present and future", Allergy, 66, pp.1~14 (2011)
  4. Wood RA, "Anaphylaxis in America : the prevalence and characteristics of anaphylaxis in the United States", J Allergy Clin Immunol, 133, pp.461~467 (2014)
  5. Panesar SS, "The epidemiology of anaphylaxis in Europe : a systematic review", Allergy, 68, pp.1353~1361 (2013)
  6. 임대현, "소아청소년에서 아나필락시스의 역학", Korean Journal of Pediatrics, 51(4), pp.351~354 (2008), 대한소아과학회
  7. 예영민, "Predictors of the Severity and Serious Outcomes of Anaphylaxis in Korean Adults: A Multicenter Retrospective Case Study", Allergy, Asthma & Immunology Research, 7(1), pp.22~29 (2015), 대한천식알레르기학회
  8. Muraro A, "Anaphylaxis : guidelines from the European Academy of Allergy and Clinical Immunology", Allergy, 69, pp.1026~1045 (2014)
  9. Russell WS, "Evaluating the management of anaphylaxis in US emergency departments:Guidelines vs. practice", World J Emerg Med, 4, pp.98~106 (2013)
  10. 장광천, "한국 아나필락시스의 진료", Allergy Asthma & Respiratory Diseases, 1(3), pp.181~196 (2013), 대한 소아알레르기 호흡기학회
  11. Koplin JJ, "An update on epidemiology of anaphylaxis in children and adults", Curr Opin Allergy Clin Immunol, 11, pp.492~496 (2011)
  12. Sicherer SH, "Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2013", J Allergy Clin Immunol, 133, pp.324~334 (2014)
  13. Jerschow E, "Fatal anaphylaxis in the United States, 1999-2010: temporal patterns and demographic associations", J Allergy Clin Immunol, 134, pp.1318~1328.e7 (2014)
  14. Simons FE, "Anaphylaxis pathogenesis and treatment", Allergy, 66(Suppl 95), pp.31~34 (2011)
  15. Rudders SA, "North-south differences in US emergency department visits for acute allergic reactions", Ann Allergy Asthma Immunol, 104, pp.413~416 (2010)
  16. Sheikh A, "Age, sex, geographical and socio-economic variations in admissions for anaphylaxis: analysis of four years of English hospital data", Clin Exp Allergy, 31, pp.1571~1576 (2001)
  17. Harduar-Morano L, "A populationbased epidemiologic study of emergency department visits for anaphylaxis in Florida", J Allergy Clin Immunol, 128, pp.594~600.e1 (2011)
  18. Decker WW, "The etiology and incidence of anaphylaxis in Rochester, Minnesota:a report from the Rochester Epidemiology Project", J Allergy Clin Immunol, 122, pp.1161~1165 (2008)
  19. Camargo CA Jr, "Regional differences in EpiPen prescriptions in the United States : the potential role of vitamin D", J Allergy Clin Immunol, 120, pp.131~136 (2007)
  20. Mullins RJ, "Regional variation in epinephrine autoinjector prescriptions in Australia : more evidence for the vitamin Danaphylaxis hypothesis", Ann Allergy Asthma Immunol, 103, pp.488~495 (2009)
  21. Yang MS, "Epidemiologic and clinical features of anaphylaxis in Korea", Ann Allergy Asthma Immunol, 100, pp.31~36 (2008)
  22. 김무정, "수원의 한 대학병원에서 10년간 경험한 아나필락시스 환자 분석", 천식 및 알레르기, 28(4), pp.298~304 (2008), 대한천식알레르기학회
  23. 이만영, "국내 양봉산업 현황", Journal of Apiculture, 25(2), pp.137~144 (2010), 한국양봉학회

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