1999년, 2005년, 2008년 피부반응검사 분석을 통해 본 지난 10년간 경기 남부지역 대학병원에 내원한 알레르기 환자의 화분 알레르겐 감작률의 변화
Changes in Sensitization Rates to Pollen Allergens in Allergic Patients in the Southern Part of Gyeonggi Province Over the Last 10 Years
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Background: Pollen is a typical outdoor allergen, which is known as a major factor causing respiratory allergic diseases. Objective: This study was designed to observe changes in the sensitization rate to pollen allergens and their characteristics in the southern part of Gyeonggi Province over the last 10 years. Method: Targeting 7,103 patients in total, the results of allergy skin prick tests were obtained in 1999, 2005 and 2008. We assessed changes in skin reactivity to 13 major inhalant allergens, including alder, oak and beech, that cause pollinosis in spring as well as mugwort, ragweed and Hop J pollens that cause pollinosis in autumn, based on the rates of allergen/histamine wheal responses. Higher ratios than 1were regarded as positive results. Result: The sensitization rates to tree pollens were increased gradually in 1999, 2005 and 2008. The sensitization rates to alder were 5.5% in 1999, 6.2%in 2005 and 9% in 2008 those to oak were 6.7% in 1999, 8.5% in 2005 and 9.6% in 2008. Also, the sensitization rates to weed pollens were increased gradually in 1999, 2005 and 2008 as well. The sensitization rates to mugwort were 11.3% in 1999,13.1% in 2005 and 15.2% in 2008; those to Hop J were 7.1% in 1999, 8.0% in 2005 and 9.6% in 2008. Especially in cases of Hop J, the proportion of patients with high rates (more than 5+) tended to increase from 27.5% in 1999 to 31.3% in 2005 and 36.9% in 2008. The time point where the sensitization rate started to obviously increase was advanced from September to July, which implies the extension of the sensitization period. Conclusion: The sensitization rates to tree and weed pollens have increased significantly in the southern part of Gyeonggi Province over the last 10 years, which has been noted among the patients at different ages, especially young children and adults over their 40s. An increase in the degree of skin reactivity and the extension of the sensitization period were observed in cases of Hop J.
Abstract
Background: Pollen is a typical outdoor allergen, which is known as a major factor causing respiratory allergic diseases. Objective: This study was designed to observe changes in the sensitization rate to pollen allergens and their characteristics in the southern part of Gyeonggi Province over the last 10 years. Method: Targeting 7,103 patients in total, the results of allergy skin prick tests were obtained in 1999, 2005 and 2008. We assessed changes in skin reactivity to 13 major inhalant allergens, including alder, oak and beech, that cause pollinosis in spring as well as mugwort, ragweed and Hop J pollens that cause pollinosis in autumn, based on the rates of allergen/histamine wheal responses. Higher ratios than 1were regarded as positive results. Result: The sensitization rates to tree pollens were increased gradually in 1999, 2005 and 2008. The sensitization rates to alder were 5.5% in 1999, 6.2%in 2005 and 9% in 2008 those to oak were 6.7% in 1999, 8.5% in 2005 and 9.6% in 2008. Also, the sensitization rates to weed pollens were increased gradually in 1999, 2005 and 2008 as well. The sensitization rates to mugwort were 11.3% in 1999,13.1% in 2005 and 15.2% in 2008; those to Hop J were 7.1% in 1999, 8.0% in 2005 and 9.6% in 2008. Especially in cases of Hop J, the proportion of patients with high rates (more than 5+) tended to increase from 27.5% in 1999 to 31.3% in 2005 and 36.9% in 2008. The time point where the sensitization rate started to obviously increase was advanced from September to July, which implies the extension of the sensitization period. Conclusion: The sensitization rates to tree and weed pollens have increased significantly in the southern part of Gyeonggi Province over the last 10 years, which has been noted among the patients at different ages, especially young children and adults over their 40s. An increase in the degree of skin reactivity and the extension of the sensitization period were observed in cases of Hop J.
참고문헌 (28)
- Sears MR, "The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma", Clin Exp Allergy, 19, pp.419~424 (1989)
- Barbee RA, "Immediate skin-test reactivity in a general population sample", Ann Intern Med, 84, pp.129~133 (1976)
- Boulet LP, "Comparative degree and type of sensitization to common indoor and outdoor allergens in subjects with allergic rhinitis and", or asthma, 1997, pp.27, 52~59
- Park HS, "Survey of airborne pollens in Seoul, Korea", J Korean Med Sci, 9, pp.42~46 (1994)
- D'Amato G, "Allergenic pollen and pollen allergy in Europe", Allergy, 62, pp.976~990 (2007)
- Beggs PJ, "Impacts of climate change on aeroallergens: past and future", Clin Exp Allergy, 34, pp.1507~1513 (2004)
- 오재원, "한국 공중화분의 특징과 최근의 변화", 천식 및 알레르기, 27(1), pp.1~7 (2007), 대한천식알레르기학회
- Beasley R, "Prevalence and etiology of asthma", J Allergy Clin Immunol, 105, pp.466~472 (2000)
- Sommer J, "Allergic disease--pollen allergy and climate change", Ugeskr Laeger, 171, pp.3184~3187 (2009)
- Indrajana T, "Comparative study of the intracutaneous, scratch and prick tests in allergy", Ann Allergy, 29, pp.639~650 (1971)
- Nelson HS, "Diagnostic procedures in allergy. I. Allergy skin testing", Ann Allergy, 51, pp.411~418 (1983)
- 김태범, "흡입 알레르겐에 대한 감작율: 다기관 공동연구", 천식 및 알레르기, 23(3), pp.483~493 (2003), 대한천식알레르기학회
- Kim MK, "Change of causative inhalant allergens in respiratory allergic patients in Chungbuk district", Korean J Asthma Allergy Clin Immunol, 19, pp.696~702 (1999)
- Kim CW, "Changing patterns of skin reactivity to inhalant allergens in asthmatic patients", Korean J Asthma Allergy Clin Immunol, 21, pp.205~215 (2001)
- 오재원, "소아에서 잡초류 알레르기 감작률의 증가와 알레르기성 잡초류의 연중 화분량과의 상관관계", 대한소아알레르기및호흡기학회지, 16(2), pp.114~121 (2006), 대한 소아알레르기 호흡기학회
- Ariano R, "Airborne pollens and prevalence of pollenosis in western Liguria: a 10-year study", J Investig Allergol Clin Immunol, 9, pp.229~234 (1999)
- Zwick H, "Pollen sensitization and allergy in children depend on the pollen load", Allergy, 46, pp.362~366 (1991)
- 오재원, "알레르기 화분의 특성과 최근 소아에서 잡초류 화분의 감작률 증가", Korean Journal of Pediatrics, 51(4), pp.355~361 (2008), 대한소아과학회
- Popp W, "Sensitization to aeroallergens depends on environmental factors", Allergy, 44, pp.572~575 (1989)
- Garcia-Mozo H, "Quercus pollen season dynamics in the Iberian peninsula: response to meteorological parameters and possible consequences of climate change", Ann Agric Environ Med, 13, pp.209~224 (2006)
- Stach A, "Prevalence of artemisia species pollinosis in western Poland: impact of climate change on aerobiological trends, 1995-2004", J Investig Allergol Clin Immunol, 17, pp.39~47 (2007)
- Breton MC, "Relationship between climate, pollen concentrations of Ambrosia and medical consultations for allergic rhinitis in Montreal, 1994-2002", Sci Total Environ, 370, pp.39~50 (2006)
- Mohan JE, "Biomass and toxicity responses of poison ivy (Toxicodendron radicans) to elevated atmospheric CO2", Proc Natl Acad Sci U S A, 103, pp.9086~9089 (2006)
- Koenig JQ, "Air pollution and asthma", J Allergy Clin Immunol, 104, pp.717~722 (1999)
- Peden DB, "Mechanisms of pollution-induced airway disease: in vivo studies", Allergy, 52, pp.37~44 (1997)
- Svartengren M, "Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen", Eur Respir J, 15, pp.716~724 (2000)
- Nordenhall C, "Diesel exhaust enhances airway responsiveness in asthmatic subjects", Eur Respir J, 17, pp.909~915 (2001)
- McCreanor J, "Respiratory effects of exposure to diesel traffic in persons with asthma", N Engl J Med, 357, pp.2348~2358 (2007)