Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
C1q/TNF-α Related Protein 1 (CTRP1), an adiponectin paralog, is a novel member of the C1q-TNF Related Protein family. CTRP1 is expressed in the kidney, although its localization and role in the kidney have not been studied. This study examined CTRP1 expression and function in the kidney. CTRP1 immunohistochemistry and PAS staining of the kidneys of C57/BL6 and FGS/Nga mice were performed. In situ hybridization for podocin in the kidney was also performed. CTRP1 immunoreactivity was found only in the glomeruli of the kidney. The CTRP1-immunoreactive cells in the glomeruli were identified as podocytes. The number of CTPR1-immunoreactive cells and the intensity of CTRP1 immunoreactivity were lower in the glomeruli of FGS/Nga mice, which develop progressive proteinuria and focal glomerulosclerosis. CTRP1 is a novel protein expressed in podocytes of the mouse kidney and may have a role in podocytes related to glomerular filtration in the kidney.
Abstract
C1q/TNF-α Related Protein 1 (CTRP1), an adiponectin paralog, is a novel member of the C1q-TNF Related Protein family. CTRP1 is expressed in the kidney, although its localization and role in the kidney have not been studied. This study examined CTRP1 expression and function in the kidney. CTRP1 immunohistochemistry and PAS staining of the kidneys of C57/BL6 and FGS/Nga mice were performed. In situ hybridization for podocin in the kidney was also performed. CTRP1 immunoreactivity was found only in the glomeruli of the kidney. The CTRP1-immunoreactive cells in the glomeruli were identified as podocytes. The number of CTPR1-immunoreactive cells and the intensity of CTRP1 immunoreactivity were lower in the glomeruli of FGS/Nga mice, which develop progressive proteinuria and focal glomerulosclerosis. CTRP1 is a novel protein expressed in podocytes of the mouse kidney and may have a role in podocytes related to glomerular filtration in the kidney.
참고문헌 (22)
- Shapiro L, "The crystal structure of a complement- 1q family protein suggests an evolutionary link to tumor necrosis factor", Curr Biol, 8, pp.335~338 (1998)
- Rovin BH, "Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus", Kidney Int, 68, pp.1825~1833 (2005)
- Heimburger O, "Adipokines in chronic kidney disease-fat tissue gives nephrologists a message", Perit Dial Int, 25, pp.340~342 (2005)
- Isobe T, "Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study", Eur J Endocrinol, 153, pp.91~98 (2005)
- Ignacy W, "Reciprocal association of plasma adiponectin and serum C-reactive protein concentration in haemodialysis patients with end-stage kidney disease--a follow-up study", Nephron Clin Pract, 101, pp.18~24 (2005)
- Schalkwijk CG, "EURODIAB Prospective Complications Study Group. Adiponectin is inversely associated with renal function in type 1 diabetic patients", J Clin Endocrinol Metab, 91, pp.129~135 (2006)
- Wong GW, "A family of Acrp30", adiponectin structural and functional paralogs, 2004, pp.101, 10302~10307
- Lasser G, "C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen", Blood, 107, pp.423~430 (2006)
- Yoshida F, "Renal lesions of the FGS strain of mice: a spontaneous animal model of progressive glomerulosclerosis", Nephron, 66, pp.317~325 (1994)
- Kim EH, "Changes of renal lesion-related parameters in FGS", Nga and the parental mouse strains, CBA, Nga, pp.Exp Anim, 2004[DOI]
- Jiang T, "Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease", Kidney Int, 68, pp.2608~2620 (2005)
- Pedrycz A, "Histological and histochemical assessment of the effects of a single dose adriamycin on fetal rat kidney", Acta Histochem, 107, pp.215~220 (2005)
- Jeon JH, "A novel adipokine CTRP1 stimulates aldosterone production", FASEB J, 22, pp.1502~1511 (2008)
- Kim KY, "Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue", FEBS Lett, 580, pp.3953~3960 (2006)
- Ishikawa Y, "Changes in the distribution pattern of gelatin-binding protein of 28 kDa (adiponectin) in myocardial remodelling after ischaemic injury", Histopathology, 42, pp.43~52 (2003)
- Diez JJ, "The role of the novel adipocyte-derived hormone adiponectin in human disease", Eur J Endocrinol, 148, pp.293~300 (2003)
- Ouchi N, "Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin", Circulation, 100, pp.2473~2476 (1999)
- Kawanami D, "Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine- endothelial cell interactions", Biochem Biophys Res Commun, 314, pp.415~419 (2004)
- Kumada M, "Adiponectin specifically increased tissueinhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages", Circulation, 109, pp.2046~2049 (2004)
- Chen H, "Adiponectin stimulates production of nitric oxide in vascular endothelial cells", J Biol Chem, 278, pp.45021~45026 (2003)
- Asanuma K, "The role of podocytes in glomerular pathobiology", Clin Exp Nephrol, 7, pp.255~259 (2003)
- Levidiotis V, "New insights into the molecular biology of the glomerular filtration barrier and associated disease", Nephrology, 10, pp.157~166 (2005)