Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma
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The prognostic value of collagen 24A1 (COL24A1) and its association with tumor-infiltrating immune cells (TIICs) in hepatocellular carcinoma (HCC) remains unexplored. In this study, we aimed to evaluate the prognostic value of COL24A1 in HCC via comprehensive web database analysis such as various online databases, including the Tumor Immune Estimation Resource (TIMER), The University of ALabama at Birmingham CANcer data analysis, Kaplan-Meier plotter, and Gene Expression Profiling Interactive Analysis. COL24A1 mRNA expression was found to be upregulated in HCC as compared to that in normal tissues, which was associated with poor prognosis in HCC. Further, COL24A1 expression correlated positively with TIICs, including B cells, CD8+T cells, neutrophils, macrophages, and dendritic cells, which was also associated with poor prognosis in HCC. The TIMER database revealed positive correlations between COL24A1 expression and that of other collagen family members, including, COL1A1, COL5A1, COL16A1 and COL21A1 in HCC. Our findings demonstrate that COL24A1 may potentially serve as a prognostic biomarker in patients with HCC.
Abstract
The prognostic value of collagen 24A1 (COL24A1) and its association with tumor-infiltrating immune cells (TIICs) in hepatocellular carcinoma (HCC) remains unexplored. In this study, we aimed to evaluate the prognostic value of COL24A1 in HCC via comprehensive web database analysis such as various online databases, including the Tumor Immune Estimation Resource (TIMER), The University of ALabama at Birmingham CANcer data analysis, Kaplan-Meier plotter, and Gene Expression Profiling Interactive Analysis. COL24A1 mRNA expression was found to be upregulated in HCC as compared to that in normal tissues, which was associated with poor prognosis in HCC. Further, COL24A1 expression correlated positively with TIICs, including B cells, CD8+T cells, neutrophils, macrophages, and dendritic cells, which was also associated with poor prognosis in HCC. The TIMER database revealed positive correlations between COL24A1 expression and that of other collagen family members, including, COL1A1, COL5A1, COL16A1 and COL21A1 in HCC. Our findings demonstrate that COL24A1 may potentially serve as a prognostic biomarker in patients with HCC.
참고문헌 (34)
- Ricard-Blum S, "The collagen family", Cold Spring Harb Perspect Biol, 3, pp.a004978~ (2011)
- San Antonio JD, "Collagen Structure-Function Mapping Informs Applications for Rege-nerative Medicine", Bioengineering, 8, pp.3~ (2020)
- Wu X, "Collagen facilitates the colorectal cancer stemness and metastasis through an integrin", PI3K, Snail signaling pathway, pp.Biomed Pharmacother, 2019[DOI]
- Salimian N, "Collagen 1A1(COL1A1)and Collagen11A1(COL11A1)as diagnostic biomarkers in Breast, colorectal and gastric cancers", Gene, 892, pp.147867~ (2024)
- Ma HP, "Collagen 1A1(COL1A1)Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis", Cancers(Basel), 11, pp.786~ (2019)
- Li A, "COL11A1 is overexpressed in gastric cancer tissues and regulates proliferation, migration and invasion of HGC-27 gastric cancer cells in vitro", Oncol Rep, 37, pp.333~340 (2017)
- Wu Y, "Integrated bioinformatics analysis of expression and gene regulation network of COL12A1 in colorectal cancer", Cancer Med, 9, pp.4743~4755 (2020)
- Villanueva A, "Hepatocellular carcinoma", N Engl J Med, 380, pp.1450~1462 (2019)
- Sangiovanni A, "Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance", Gastroenterology, 126, pp.1005~1014 (2004)
- Singal AG, "Hepatocellular carcinoma from epidemiology to prevention : Translating knowledge into practice", Clin Gastroenterol Hepatol, 13, pp.2140~2151 (2015)
- Zheng X, "Progression on the roles and mechanisms of tumor-infiltrating T lymphocytes in patients with hepatocellular carcinoma", Front Immunol, 12, pp.729705~ (2021)
- Matsuo N, "Collagen XXIV(Col24a1)gene expression is a specific marker of osteoblast differentiation and bone formation", Connect Tissue Res, 49, pp.68~75 (2008)
- Misawa K, "Prognostic value of type XXII and XXIV collagen mRNA expression in head and neck cancer patients", Mol Clin Oncol, 2, pp.285~291 (2014)
- Li T, "TIMER : A web server for comprehensive analysis of tumor-infiltrating immune cells", Cancer Res, 77, pp.e108~e110 (2017)
- Wu Z, "Prognostic significance of SNCA and its methylation in bladder cancer", BMC Cancer, 22, pp.330~ (2022)
- Györffy B, "An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients", Breast Cancer Res Treat, 123, pp.725~731 (2010)
- Lánczky A, "miRpower : A web-tool to validate survival-associ-ated miRNAs utilizing expression data from 2178 breast cancer patients", Breast Cancer Res Treat, 160, pp.439~446 (2016)
- An Y, "OSlihc : An online prognostic biomarker analysis tool for hepatocellular carcinoma", Front Pharmacol, 11, pp.875~ (2020)
- Chen Y, "Type I collagen deletion in alphaSMA(+)myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer", Cancer Cell, 39, pp.548~565 (2021)
- Liu J, "Collagen 1A1(COL1A1)promotes metastasis of breast cancer and is a potential therapeutic target", Discov Med, 25, pp.211~223 (2018)
- Li T, "TGF-beta1-SOX9 axis-inducible COL10A1 promotes invasion and metastasis in gastric cancer via epithelial-to-mesenchymal transition", Cell Death Dis, 9, pp.849~ (2018)
- Wang H, "Over-expression of CDX2 alleviates breast cancer by up-regulating microRNA let-7b and inhibiting COL11A1 expression", Cancer Cell Int, 20, pp.13~ (2020)
- Uehara T, "Molecular mechanisms of fibrosis-associa-ted promotion of liver carcinogenesis", Toxicol Sci, 132, pp.53~63 (2013)
- Wallace MC, "The evolving epidemiology of hepatocellular carcinoma : a global perspective", Expert Rev Gastroenterol Hepatol, 9, pp.765~779 (2015)
- Kim HR, "C4orf47 is a novel prognostic biomarker and correlates with infiltrating immune cells in hepatocellular carcinoma", Biomed Sci Lett, 29, pp.11~25 (2023)
- Kim HR, "Zinc finger E-box binding homeobox 1 as prognostic biomarker and its correlation with infiltrating immune cells and telomerase in lung cancer", Biomed Sci Lett, 28, pp.9~24 (2022)
- Kim HR, "SAMD13 as a novel prognostic biomarker and its correlation with infiltrating immune cells in hepatocellular carcinoma", Biomed Sci Lett, 28, pp.260~275 (2022)
- Yan L, "Overexpression of COL24A1 in hepato-cellular carcinoma predicts poor prognosis : A study based on multiple databases, clinical samples and cell lines", Onco Targets Ther, 13, pp.2819~2832 (2020)
- Wang F, "Identification of novel diagnostic and prognostic biomarkers for hepatocellular carcinoma", Oncol Rep, 43, pp.87~98 (2020)
- Ostrand-Rosenberg S, "Immune surveillance : A balance between protumor and antitumor immunity", Curr Opin Genet Dev, 18, pp.11~18 (2008)
- Munhoz RR, "Recent advances in understanding antitumor immunity", F1000Res, 5, pp.2545~ (2016)
- Necula L, "Collagen family as promising biomarkers and therapeutic targets in cancer", Int J Mol Sci, 23, pp.12415~ (2022)
- Zhang J, "Overexpressed COL5A1 is correlated with tumor progression, paclitaxel resistance, and tumor-infiltrating immune cells in ovarian cancer", J Cell Physiol, 236, pp.6907~6919 (2021)
- Gu S, "COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas", Front Oncol, 11, pp.752694~ (2021)