혈청 Ghrelin 농도와 기도과민성과의 연관성
Serum Ghrelin Level is Associated with Severity of Bronchial Hyperresponsiveness
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Background: The prevalences of both asthma and obesity have increased. One possibility of this increase is systemic changes in immune function in obese subjects. Several obesity-related hormones and cytokines have a proinflammatory effect on the airway, which may lead to bronchial hyperresponsiveness (BHR). Objective: To determine whether 2 representative appetite-regulating hormones (leptin and ghrelin) are associated with BHR. Method: Thirty-nine non-smoker adults, who had cough or dyspnea, were enrolled in this study. Subjects were divided into 3 groups according to the level of methacholine PC20 (moderate to severe, ＜2 mg/mL; mild, 2≤PC20＜8 mg/mL; normal, ≥8 mg/mL). Subjects in each group were age, sex and body mass index. The serum levels of leptin and ghrelin were analyzed by enzyme immunoassay. Result: There were significant differences in the serum ghrelin level between 3 groups (P=0.036). The serum level of ghrelin was the lowest in the moderate to severe BHR group (4.7 ng/mL), followed by 6.1 in the mild BHR group and 18.6 in the normal BHR group. There were no significant differences in the serum leptin level between 3 groups (54.1 vs. 57.6 vs. 53.2 pg/mL; P=0.982). Conclusion: Ghrelin may play an essential role in the prevention of BHR.
Abstract
Background: The prevalences of both asthma and obesity have increased. One possibility of this increase is systemic changes in immune function in obese subjects. Several obesity-related hormones and cytokines have a proinflammatory effect on the airway, which may lead to bronchial hyperresponsiveness (BHR). Objective: To determine whether 2 representative appetite-regulating hormones (leptin and ghrelin) are associated with BHR. Method: Thirty-nine non-smoker adults, who had cough or dyspnea, were enrolled in this study. Subjects were divided into 3 groups according to the level of methacholine PC20 (moderate to severe, ＜2 mg/mL; mild, 2≤PC20＜8 mg/mL; normal, ≥8 mg/mL). Subjects in each group were age, sex and body mass index. The serum levels of leptin and ghrelin were analyzed by enzyme immunoassay. Result: There were significant differences in the serum ghrelin level between 3 groups (P=0.036). The serum level of ghrelin was the lowest in the moderate to severe BHR group (4.7 ng/mL), followed by 6.1 in the mild BHR group and 18.6 in the normal BHR group. There were no significant differences in the serum leptin level between 3 groups (54.1 vs. 57.6 vs. 53.2 pg/mL; P=0.982). Conclusion: Ghrelin may play an essential role in the prevention of BHR.
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