성인에서 기관지과민성과 폐기능의 지표로서 High-Sensitivity C-Reactive Protein의 의미
High-Sensitivity C-Reactive Protein as a Marker of Bronchial Hyperresponsiveness and Lung Function
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Background: Bronchial hyperresponsiveness is a characteristic feature of asthma and closely related with airway inflammation in part. Serum high-sensitivity C-reactive protein (hs-CRP) is a very sensitive marker for systemic inflammation, and several studies has reported the association between hs-CRP and bronchial hyperresponsiveness. Objective: The objectives of this study are to evaluate the association between hs-CRP and bronchial hyperresponsiveness or lung function in healthy Korean subjects. Method: A total of 7,709 subjects underwent methacholine bronchial provocation tests in Seoul National University Hospital health care Gangnam center from October 2003 to January 2009. Among them, 508 subjects were positive for the methacholine bronchial provocationtest. Another 508 subjects negative for the test were enrolled as control, who were matched for age, sex and body mass index. We reviewed the medical records and compared serum hs-CRP levels and the results of the methacholine bronchial provocation test and pulmonary function tests. Result: Bronchial hyperresponsiveness was more frequently observed in subjects with higher hs-CRP levels (group IV). (24.6% vs. 14.8%) than in subjects with lower hs-CRP levels (group Ⅰ). There was a negative correlation with hs-CRP levels and FEV1, FVC or FEV1/FVC. Conclusion: There was a negative association between serum hs-CRP levels and bronchial hyperresponsiveness or lung function.
Abstract
Background: Bronchial hyperresponsiveness is a characteristic feature of asthma and closely related with airway inflammation in part. Serum high-sensitivity C-reactive protein (hs-CRP) is a very sensitive marker for systemic inflammation, and several studies has reported the association between hs-CRP and bronchial hyperresponsiveness. Objective: The objectives of this study are to evaluate the association between hs-CRP and bronchial hyperresponsiveness or lung function in healthy Korean subjects. Method: A total of 7,709 subjects underwent methacholine bronchial provocation tests in Seoul National University Hospital health care Gangnam center from October 2003 to January 2009. Among them, 508 subjects were positive for the methacholine bronchial provocationtest. Another 508 subjects negative for the test were enrolled as control, who were matched for age, sex and body mass index. We reviewed the medical records and compared serum hs-CRP levels and the results of the methacholine bronchial provocation test and pulmonary function tests. Result: Bronchial hyperresponsiveness was more frequently observed in subjects with higher hs-CRP levels (group IV). (24.6% vs. 14.8%) than in subjects with lower hs-CRP levels (group Ⅰ). There was a negative correlation with hs-CRP levels and FEV1, FVC or FEV1/FVC. Conclusion: There was a negative association between serum hs-CRP levels and bronchial hyperresponsiveness or lung function.
참고문헌 (25)
- Zhong NS, "Is asymptomatic bronchial hyperresponsiveness an indication of potential asthma?. in: A two year follow up of young students with bronchial hyperresponsiveness", Chest, 102, pp.2204~2209 (1992)
- Kim YK, "Bronchial responsiveness to methacholine in general population without bronchial asthma", J Asthma Allergy Clin Immunol, 18, pp.416~425 (1998)
- Busse WW, "Asthma", N Engl J Med, 344, pp.350~362 (2001)
- Jousilahti P, "The association of sensitive systemic inflammation markers with bronchial asthma", Ann Allergy Asthma Immunol, 89, pp.381~385 (2002)
- Buyukozturk S, "Acute phase reactants in allergic airway disease", Tohoku J Exp Med, 204, pp.209~213 (2004)
- Arif AA, "Association between asthma, asthma symptoms and C-reactive protein in US adults: data from the National Health and Nutrition Examination Survey, 1999-2002", Respirology, 12, pp.675~682 (2007)
- Wouters EFM, "The systemic face of airway disease: the role of C-reactive protein", Eur Respir J, 27, pp.877~879 (2006)
- Anderson GP, "COPD, asthma and C-reactive protein", Eur Respir J, 27, pp.874~876 (2006)
- Hancox RJ, "Systemic inflammation and lung function in young adults", Thorax, 62, pp.1064~1068 (2007)
- Aronson D, "Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects", Am J Respir Crit Care Med, 174, pp.626~632 (2006)
- O'Connor GT, "A prospective longitudinal study of methacholine airway hyperresponsiveness as a predictor of pulmonary-function decline?: the Normative Aging Study", Am J Respir Crit Care Med, 152, pp.87~92 (1995)
- Rijcken B, "Thyperresponsiveness to histamine associated with accelerated decline in FEV1", Am J Respir Crit Care Med, 151, pp.1377~1382 (1995)
- Kony S, "Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study", Thorax, 59, pp.892~896 (2004)
- Chai H, "Antigen and metacholine challenge in children with asthma", J allergy Clin Immunol, 64, pp.575~579 (1979)
- Janeway CA, "Innate immunity. in: Immunobiology: the immune system in health and disease. 5th ed", pp.38~88 (2001), Gerland Publishing
- Pepsys MB, "Hirschfield GM. C-reactive protein: a critical update", J Clin invest, 111, pp.1805~1812 (2003)
- Black S, "C-reactive protein", J Biol Chem, 47, pp.487~490 (2004)
- Pearson TA, "Markers of inflammation and cardio vascular disease: application to clinical and public health practice: a statement for healthcare professionals from the center for disease control and prevention and the American Heart Association", Circulation, 107, pp.499~511 (2003)
- de Torres JP, "C-reactive protein levels and clinical important predictive outcomes in stable COPD patients", Eur Respir J, 27, pp.902~907 (2006)
- Takemura M, "High sensitivity C-reactive protein in asthma", Eur Respir J, 27, pp.908~912 (2006)
- Olafsdottir IS, "C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study", Thorax, 60, pp.451~454 (2005)
- Soferman R, "Hs-CRP levels: Measurement of airway inflammation in asthmatic children", Pediatrics International, 50, pp.12~16 (2008)
- Zietkowski Z, "High-sensitivity C-reactive protein in the exhaled breath condensate and serum in stable and unstable asthma", Respir Med, 103, pp.379~385 (2009)
- Butland BK, "C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults", Eur Respir J, 32, pp.77~84 (2008)
- Panaszek B, "Serum concentration of C-reactive protein is not a good marker of bronchial hyperresponsiveness", Arch Immunol Ther Exp, 55, pp.341~345 (2007)