그레이브스병 환자에서 알레르기 지표와 갑상선자극호르몬 수용체 항체의 관련성
Association between Atopic Parameters and Thyrotropin-Binding Inhibitory Immunoglobulin in Graves' Disease
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초록
Background: IgE might play a role in the pathogenesis of Graves’ disease in Japanese population. Objective: We designed this study to evaluate the possible relationship between atopic parameters and the level of TSH receptor antibody in Graves' disease. Method: In 406 patients with Graves' disease, we measured total IgE, eosinophil count and specific IgE against Dermatophagoides farinae (D. farinae), as well as TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin [TBII]). We collected histories of common allergic diseases by a questionnaire and performed skin tests with 8 common aeroallergens. Result: TBII was higher in patients who had treatment history or clinical symptoms of asthma within 12 months and also higher in smokers. TBII was positively related to total IgE. Duration of treatment was significantly lower and total IgE was significantly higher in TBII ≥15 IU/L group than those of TBII ＜15 IU/L group. TBII was significantly higher in group of specific IgE against D. farinae ≥0.7kU/L. Total IgE level was higher in whom need medication for maintaining euthyroid state than that of remission state patients. Conclusion: TBII was significantly related to atopic markers including total IgE, specific IgE against D. farinae and history of asthma, suggesting that there is a close link between autoimmune thyroid disease and allergic immune response.
Abstract
Background: IgE might play a role in the pathogenesis of Graves’ disease in Japanese population. Objective: We designed this study to evaluate the possible relationship between atopic parameters and the level of TSH receptor antibody in Graves' disease. Method: In 406 patients with Graves' disease, we measured total IgE, eosinophil count and specific IgE against Dermatophagoides farinae (D. farinae), as well as TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin [TBII]). We collected histories of common allergic diseases by a questionnaire and performed skin tests with 8 common aeroallergens. Result: TBII was higher in patients who had treatment history or clinical symptoms of asthma within 12 months and also higher in smokers. TBII was positively related to total IgE. Duration of treatment was significantly lower and total IgE was significantly higher in TBII ≥15 IU/L group than those of TBII ＜15 IU/L group. TBII was significantly higher in group of specific IgE against D. farinae ≥0.7kU/L. Total IgE level was higher in whom need medication for maintaining euthyroid state than that of remission state patients. Conclusion: TBII was significantly related to atopic markers including total IgE, specific IgE against D. farinae and history of asthma, suggesting that there is a close link between autoimmune thyroid disease and allergic immune response.
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