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알레르기질환 및 아토피피부염에서 가려움증의 병인 및 치료적 접근

Pathophysiology and Therapy of Pruritus in Allergic and Atopic Diseases

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키워드

주제분류임상병리학

초록

Pruritus, briefly defined as an unpleasant sensation provoking the desire to scratch, is a major characteristic and one of the most debilitating symptoms in allergic diseases and atopic dermatitis. Although recent observations have clearly improved our knowledge of the pathophysiology of pruritus, it is still too complex involving neurophysiological and neuroimmunological aspects. In this review, we summarize the current information regarding the role of mediators and receptors related to trigger or inhibit pruritus,and the management of pruritus in allergic and atopic disease.

Abstract

Pruritus, briefly defined as an unpleasant sensation provoking the desire to scratch, is a major characteristic and one of the most debilitating symptoms in allergic diseases and atopic dermatitis. Although recent observations have clearly improved our knowledge of the pathophysiology of pruritus, it is still too complex involving neurophysiological and neuroimmunological aspects. In this review, we summarize the current information regarding the role of mediators and receptors related to trigger or inhibit pruritus,and the management of pruritus in allergic and atopic disease.

참고문헌 (47)

  1. Shin YW, "Pruritus, psychocutaneous disorders, neurocutaneous dermatoses. in Dermatology. 5th ed", pp.93~104 (2008), Ryo Moon Gak
  2. Steinhoff M, "Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus", J Invest Dermatol, 126, pp.1705~18 (2006)
  3. Schmelz M, "Specific C-receptors for itch in human skin", J Neurosci, 17, pp.8003~8 (1997)
  4. Andrew D, "Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch", Nat Neurosci, 4, pp.72~7 (2001)
  5. Carstens EE, "Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats", Neuroreport, 21, pp.303~8 (2010)
  6. Sun YG, "Cellular basis of itch sensation", Science, 325, pp.1531~4 (2009)
  7. Roosterman D, "Neuronal control of skin function: the skin as a neuroimmunoendocrine organ", Physiol Rev, 86, pp.1309~79 (2006)
  8. Stander S, "Neurophysiology of pruritus: cutaneous elicitation of itch", Arch Dermatol, 139, pp.1463~70 (2003)
  9. Malaviya R, "Histamine in human epidermal cells is induced by ultraviolet light injury", J Invest Dermatol, 106, pp.785~9 (1996)
  10. Yu B, "Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis", Br J Dermatol, 162, pp.1038~43 (2010)
  11. Cowden JM, "The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation", J Invest Dermatol, 130, pp.1023~33 (2010)
  12. Steinhoff M, "Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism", Nat Med, 6, pp.151~8 (2000)
  13. Steinhoff M, "Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin", J Neurosci, 23, pp.6176~80 (2003)
  14. Jeong SK, "Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery", J Invest Dermatol, 128, pp.1930~9 (2008)
  15. Suzuki R, "Direct neurite-mast cell communication in vitro occurs via the neuropeptide substance P", J Immunol, 163, pp.2410~15 (1999)
  16. Buddenkotte J, "Pathophysiology and therapy of pruritus in allergic and atopic diseases", Allergy, 65, pp.805~21 (2010)
  17. Fjellner B, "Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK-33-824, beta-endorphin and morphine", Arch Dermatol Res, 274, pp.29~37 (1982)
  18. Togashi Y, "Antipruritic activity of the kappa-opioid receptor agonist, TRK-820", Eur J Pharmacol, 435, pp.259~64 (2002)
  19. Umeuchi H, "Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system", Eur J Pharmacol, 477, pp.29~35 (2003)
  20. Wikstrom B, "Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies", J Am Soc Nephrol, 16, pp.3742~7 (2005)
  21. Toyoda M, "Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis", Br J Dermatol, 147, pp.71~9 (2002)
  22. Groneberg DA, "Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1", J Neuroimmunol, 161, pp.87~92 (2005)
  23. Schmelz M, "Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens", J Neurophysiol, 89, pp.2441~8 (2003)
  24. Greaves MW, "McDonald-Gibson W. Itch: role of prostaglandins", Br Med J, 3, pp.608~9 (1973)
  25. Sonkoly E, "IL-31: a new link between T cells and pruritus in atopic skin inflammation", J Allergy Clin Immunol, 117, pp.411~7 (2006)
  26. Raap U, "Correlation of IL-31 serum levels with severity of atopic dermatitis", J Allergy Clin Immunol, 122, pp.421~3 (2008)
  27. Gutzmer R, "The histamine H4 receptor is functionally expressed on T(H)2 cells", J Allergy Clin Immunol, 123, pp.619~25 (2009)
  28. Liu Q, "Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus", Cell, 139, pp.1353~65 (2009)
  29. Twycross R, "Itch: scratching more than the surface", QJM, 96, pp.7~26 (2003)
  30. Stander S, "Clinical classification of itch: a position paper of the International Forum for the Study of Itch", Acta Derm Venereol, 87, pp.291~4 (2007)
  31. Yosipovitch G, "What causes itch in atopic dermatitis", Curr Allergy Asthma Rep, 8, pp.306~11 (2008)
  32. Mihara K, "Vital role of the itch-scratch response in development of spontaneous dermatitis in NC", Nga mice, 2004, pp.151, 335~45
  33. Tran BW, "Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis", Acta Derm Venereol, 90, pp.354~61 (2010)
  34. Nosbaum A, "Allergic and irritant contact dermatitis", Eur J Dermatol, 19, pp.325~32 (2009)
  35. Simpson EL, "Atopic dermatitis: a review of topical treatment options", Curr Med Res Opin, 26, pp.633~40 (2010)
  36. Senba E, "The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers", Neurosci Res, 50, pp.257~62 (2004)
  37. Pereira U, "Mechanisms of the sensory effects of tacrolimus on the skin", Br J Dermatol, 163, pp.70~7 (2010)
  38. Patel T, "Menthol: a refreshing look at this ancient compound", J Am Acad Dermatol, 57, pp.873~8 (2007)
  39. Drake LA, "Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group", J Am Acad Dermatol, 31, pp.613~6 (1994)
  40. Yosipovitch G, "The effect of topically applied aspirin on localized circumscribed neurodermatitis", J Am Acad Dermatol, 45, pp.910~3 (2001)
  41. Dawn AG, "Butorphanol for treatment of intractable pruritus", J Am Acad Dermatol, 54, pp.527~31 (2006)
  42. Kremer AE, "Oude-Elferink RP, Pusl T. Pathogenesis and treatment of pruritus in cholestasis", Drugs, 68, pp.2163~82 (2008)
  43. Narita I, "Uremic pruritus in chronic hemodialysis patients", J Nephrol, 21, pp.161~5 (2008)
  44. Manenti L, "Uraemic pruritus: clinicalcharacteristics, pathophysiology and treatment", Drugs, 69, pp.251~63 (2009)
  45. Venereau E, "Definition and characterization of an inhibitor for interleukin-31", J Biol Chem, 285, pp.14955~63 (2010)
  46. Ohmura T, "Involvement of substance P in scratching behaviour in an atopic dermatitis model", Eur J Pharmacol, 491, pp.191~4 (2004)
  47. Greaves MW, "Pathogenesis and treatment of pruritus", Curr Allergy Asthma Rep, 10, pp.236~42 (2010)

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