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p53 is not necessary for nuclear translocation of GAPDH during NO-induced apoptosis

이미영|김점지
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2011.12|BMB Reports|제44권 제12호|pp. 782-786

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참고문헌

키워드

p53Nuclear translocationGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Hepatoma cellsS-nitrosoglutathione (GSNO)
주제분류화학

초록

Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep3B cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in both HepG2 and Hep3B cells. This finding suggests that p53 may not be necessary for the GSNO-induced translocation of GAPDH to the nucleus during apoptotic cell death in hepatoma cells. [BMB reports 2011; 44(12): 782-786]

Abstract

Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep3B cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in both HepG2 and Hep3B cells. This finding suggests that p53 may not be necessary for the GSNO-induced translocation of GAPDH to the nucleus during apoptotic cell death in hepatoma cells. [BMB reports 2011; 44(12): 782-786]

참고문헌 (28)

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