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Innate immune recognition of respiratory syncytial virus infection

이흥규|김태훈
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.04|BMB Reports|제47권 제4호|pp. 184-191

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참고문헌

키워드

Toll-like receptor (TLR)Interferon-beta promoter stimulator 1 (IPS-1)Pattern recognition receptor (PRR)Respiratory syncytial virus (RSV)Retinoic acid-inducible gene-I (RIG-I)
주제분류화학

초록

Respiratory syncytial virus (RSV) is the leading cause ofrespiratory infection in infants and young children. Severeclinical manifestation of RSV infection is a bronchiolitis, whichis common in infants under six months of age. Recently, RSVhas been recognized as an important cause of respiratoryinfection in older populations with cardiovascular morbidity orimmunocompromised patients. However, neither a vaccinenor an effective antiviral therapy is currently available. Moreover, the interaction between the host immune systemand the RSV pathogen during an infection is not wellunderstood. The innate immune system recognizes RSVthrough multiple mechanisms. The first innate immune RSVdetectors are the pattern recognition receptors (PRRs),including toll-like receptors (TLRs), retinoic acid-induciblegene-I (RIG-I)-like receptors (RLRs), and nucleotide-bidingoligomerization domain (NOD)-like receptors (NLRs). Thefollowing is a review of studies associated with various PRRsthat are responsible for RSV virion recognition and subsequentinduction of the antiviral immune response during RSV infection.

Abstract

Respiratory syncytial virus (RSV) is the leading cause ofrespiratory infection in infants and young children. Severeclinical manifestation of RSV infection is a bronchiolitis, whichis common in infants under six months of age. Recently, RSVhas been recognized as an important cause of respiratoryinfection in older populations with cardiovascular morbidity orimmunocompromised patients. However, neither a vaccinenor an effective antiviral therapy is currently available. Moreover, the interaction between the host immune systemand the RSV pathogen during an infection is not wellunderstood. The innate immune system recognizes RSVthrough multiple mechanisms. The first innate immune RSVdetectors are the pattern recognition receptors (PRRs),including toll-like receptors (TLRs), retinoic acid-induciblegene-I (RIG-I)-like receptors (RLRs), and nucleotide-bidingoligomerization domain (NOD)-like receptors (NLRs). Thefollowing is a review of studies associated with various PRRsthat are responsible for RSV virion recognition and subsequentinduction of the antiviral immune response during RSV infection.

참고문헌 (67)

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