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The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

김영준|김학영|Harikrishna Reddy R|노광모
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.04|BMB Reports|제47권 제4호|pp. 192-196

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참고문헌

키워드

Cardiac hypertrophyCell cycle regulationNeuronal gene silencingSCP1Small CTD phosphatases
주제분류화학

초록

RNA polymerase II carboxyl-terminal domain (pol II CTD)phosphatases are a newly emerging family of phosphatases thatare members of DXDX (T/V). The subfamily includes Small CTDphosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 andUBLCP. Extensive study of SCP1 has elicited the diversifiedroles of the small C terminal domain phosphatase. The SCP1plays a vital role in various biological activities, like neuronalgene silencing and preferential Ser5 dephosphorylation, acts asa cardiac hypertrophy inducer with the help of its intronicmiRNAs, and has shown a key role in cell cycle regulation. Thisshort review offers an explanation of the mechanism of action ofsmall CTD phosphatases, in different biological activities andmetabolic processes.

Abstract

RNA polymerase II carboxyl-terminal domain (pol II CTD)phosphatases are a newly emerging family of phosphatases thatare members of DXDX (T/V). The subfamily includes Small CTDphosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 andUBLCP. Extensive study of SCP1 has elicited the diversifiedroles of the small C terminal domain phosphatase. The SCP1plays a vital role in various biological activities, like neuronalgene silencing and preferential Ser5 dephosphorylation, acts asa cardiac hypertrophy inducer with the help of its intronicmiRNAs, and has shown a key role in cell cycle regulation. Thisshort review offers an explanation of the mechanism of action ofsmall CTD phosphatases, in different biological activities andmetabolic processes.

참고문헌 (37)

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