Nuclear localization signal domain of HDAC3 is necessary and sufficient for the expression regulation of MDR1
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Histone acetylation/deacetylation has been known to beassociated with the transcriptional regulation of various genes. The role of histone deacetylase-3 in the expression regulationof MDR1 was investigated. The expression level of HDAC3showed an inverse relationship with the expression level ofMDR1. Wild-type HDAC3, but not catalytic mutant HDAC3S424A,negatively regulated the expression of MDR1. Wild-typeHDAC3, but not catalytic mutant HDAC3S424A, showed bindingto the promoter sequences of HDAC3. HDAC3 regulated theexpression level, and the binding of Ac-H3K9/14 and Ac-H4K16around the MDR1 promoter sequences. The nuclear localizationsignal domain of HDAC3 was necessary, and sufficient forthe binding of HDAC3 to the MDR1 promoter sequences andfor conferring sensitivity to microtubule-targeting drugs.
Abstract
Histone acetylation/deacetylation has been known to beassociated with the transcriptional regulation of various genes. The role of histone deacetylase-3 in the expression regulationof MDR1 was investigated. The expression level of HDAC3showed an inverse relationship with the expression level ofMDR1. Wild-type HDAC3, but not catalytic mutant HDAC3S424A,negatively regulated the expression of MDR1. Wild-typeHDAC3, but not catalytic mutant HDAC3S424A, showed bindingto the promoter sequences of HDAC3. HDAC3 regulated theexpression level, and the binding of Ac-H3K9/14 and Ac-H4K16around the MDR1 promoter sequences. The nuclear localizationsignal domain of HDAC3 was necessary, and sufficient forthe binding of HDAC3 to the MDR1 promoter sequences andfor conferring sensitivity to microtubule-targeting drugs.
참고문헌 (21)
- Mahlknecht, U., "Genomic organization and chromosomal localization of the human histone deacetylase 3 gene", Genomics, 56, pp.197~202 (1999)
- Li, J., "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3", EMBO J, 19, pp.4342~4350 (2000)
- Zhang, J., "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2", Mol. Cell, 9, pp.611~623 (2002)
- Mahlknecht, U., "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression", J. Immunol, 173, pp.3979~3990 (2004)
- Bardai, F. H., "Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta", J. Neurosci, 31, pp.1746~1751 (2011)
- Kim, H. C., "HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells", Cell. Mol. Life Sci, 67, pp.3499~3510 (2010)
- Ott, P. A., "Oblimersen in combination with temozolomide and albumin-bound paclitaxel in patients with advanced melanoma: a phase I trial. Cancer Chemother", Pharmacol, 71, pp.183~191 (2013)
- Chae, S., "Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis", Am. J. Physiol. Gastrointest. Liver Physiol, 302, pp.1016~1024 (2012)
- Xu, R., "Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells", Anticancer Res, 29, pp.261~270 (2009)
- Mechetner, E., "Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin", Clin. Cancer Res, 4, pp.389~398 (1998)
- Yatouji, S., "Differential modulation of nuclear texture, histone acetylation, and MDR1 gene expression in human drug-sensitive and -resistant OV1 cell lines", Int. J. Oncol, 30, pp.1003~1009 (2007)
- Kim, Y. K., "Histone deacetylase inhibitor apicidin- mediated drug resistance: involvement of P-glycoprotein", Biochem. Biophys. Res. Commun, 368, pp.959~964 (2008)
- To, K. K., "Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells", Mol. Cancer Res, 6, pp.151~164 (2008)
- Bhaskara, S., "Hdac3 is essential for the maintenance of chromatin structure and genome stability", Cancer Cell, 18, pp.436~447 (2010)
- Toth, M., "Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in multi-drug resistant cells", Cancer Science, 103, pp.659~669 (2012)
- Zhang, X., "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine", threonine phosphatase 4, 2005, pp.19, 827~839
- Kim, Y., "Cancer", testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti- cancer drugs, 2010, pp.285, 25957~25968
- Yang, W. M., "Functional domains of histone deacetylase-3", J. Biol. Chem, 277, pp.9447~9454 (2002)
- Takami, Y., "N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line", J. Biol. Chem, 275, pp.16191~16201 (2000)
- Caihong Zhou, "Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells", BMB Reports, 46(2), pp.113~118 (2013), 생화학분자생물학회
- 백수선, "Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor", BMB Reports, 46(6), pp.322~327 (2013), 생화학분자생물학회