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Regulation of Hippo signaling by actin remodeling

김준|서지명
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2018.03|BMB Reports|제51권 제3호|pp. 151-156

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참고문헌

키워드

YAPMechanotransductionTAZHippoActin
주제분류화학

초록

The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actinmediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain.

Abstract

The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actinmediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain.

참고문헌 (50)

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관련 논문AI추천

The role of extracellular biophysical cues in modulating the Hippo-YAP pathway모정순생화학분자생물학회 · BMB Reports2017 · 제50권 제2호The history and regulatory mechanism of the Hippo pathway김완태, 조익훈생화학분자생물학회 · BMB Reports2018 · 제51권 제3호DNA binding partners of YAP/TAZ김민규, 배석철, 장주원생화학분자생물학회 · BMB Reports2018 · 제51권 제3호Hippo-YAP/TAZ signaling in angiogenesis권영근, 박정애생화학분자생물학회 · BMB Reports2018 · 제51권 제3호Regulation of the Hippo signaling pathway by ubiquitin modification김영은, 조익훈생화학분자생물학회 · BMB Reports2018 · 제51권 제3호Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling권영근, 최현정생화학분자생물학회 · BMB Reports2015 · 제48권 제8호

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