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Growth signaling and longevity in mouse models

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Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.

Abstract

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.

참고문헌 (112)

  1. Barbieri M, "Insulin", IGF-I-signaling pathway : an evolutionarily conserved mechanism of longevity from yeast to humans, 2003, pp.285, E1064~E1071
  2. Fontana L, "Extending healthy life span--from yeast to humans", Science, 328, pp.321~326 (2010)
  3. Hwangbo DS, "Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body", Nature, 429, pp.562~566 (2004)
  4. Holzenberger M, "IGF-1receptor regulates lifespan and resistance to oxidative stress in mice", Nature, 421, pp.182~187 (2003)
  5. Bonafe M, "Genetic polymorphism in long-lived people : cues for the presence of an insulin", IGF-pathway-dependent network affecting human longevity, 2009, pp.299, 118~123
  6. Junnila RK, "The GH", IGF-1 axis in ageing and longevity, 2013, pp.9, 366~376
  7. Zhang J, "Tissue-specific insulin signaling in the regulation of metabolism and aging", IUBMB Life, 66, pp.485~495 (2014)
  8. Rask-Madsen C, "Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease", Arterioscler Thromb Vasc Biol, 32, pp.2052~2059 (2012)
  9. Flurkey K, "Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production", Proc Natl Acad Sci U S A, 98, pp.6736~6741 (2001)
  10. Flurkey K, "The Snell dwarf mutation Pit1(dw)can increase life span in mice", Mech Ageing Dev, 123, pp.121~130 (2002)
  11. Lin L, "Aminoacylation error correction", Nature, 384, pp.33~34 (1996)
  12. Zhou Y, "A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor", binding protein gene(the Laron mouse), 1997, pp.94, 13215~13220
  13. Coschigano KT, "Assessment of growth parameters and life span of GHR", BP gene-disrupted mice, 2000, pp.141, 2608~2613
  14. Chen WY, "Glycine 119 of bovine growth hormone is critical for growth-promoting activity", Mol Endocrinol, 5, pp.1845~1852 (1991)
  15. Chen WY, "Functional antagonism between endogenous mouse growth hormone(GH)and a GH analog results in dwarf transgenic mice", Endocrinology, 129, pp.1402~1408 (1991)
  16. Berryman DE, "Comparing adiposity profiles in three mouse models with altered GH signaling", Growth Horm IGF Res, 14, pp.309~318 (2004)
  17. Coschigano KT, "Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span", Endocrinology, 144, pp.3799~3810 (2003)
  18. Salminen A, "Regulation of longevity by FGF21 : Interaction between energy metabolism and stress responses", Ageing Res Rev, 37, pp.79~93 (2017)
  19. Kuro-o M, "Klotho and betaKlotho", Adv Exp Med Biol, 728, pp.25~40 (2012)
  20. Inagaki T, "Inhibition of growth hormone signaling by the fasting-induced hormone FGF21", Cell Metab, 8, pp.77~83 (2008)
  21. Zhang Y, "The starvation hormone, fibroblast growth factor-21, extends lifespan in mice", Elife, 1, pp.e00065~ (2012)
  22. Bartke A, "Can growth hormone(GH)accelerate aging? Evidence from GH-transgenic mice", Neuroendocrinology, 78, pp.210~216 (2003)
  23. Doi T, "Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1", Am J Pathol, 131, pp.398~403 (1988)
  24. Yang CW, "Glomerulosclerosis and body growth are mediated by different portions of bovine growth hormone. Studies in transgenic mice", Lab Invest, 68, pp.62~70 (1993)
  25. Chanson P, "Acromegaly", Orphanet J Rare Dis, 3, pp.17~ (2008)
  26. Clayton PE, "Growth hormone, the insulin-like growth factor axis, insulin and cancer risk", Nat Rev Endocrinol, 7, pp.11~24 (2011)
  27. Dozmorov I, "Array-based expression analysis of mouse liver genes : effect of age and of the longevity mutant Prop1df", J Gerontol A Biol Sci Med Sci, 56, pp.B72~B80 (2001)
  28. Dozmorov I, "Gene expression profile of long-lived snell dwarf mice", J Gerontol A Biol Sci Med Sci, 57, pp.B99~B108 (2002)
  29. Amador-Noguez D, "Gene expression profile of long-lived Ames dwarf mice and Little mice", Aging Cell, 3, pp.423~441 (2004)
  30. Boylston WH, "Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf(Pit1dw", dwJ)mice, 2004, pp.3, 283~296
  31. Tsuchiya T, "Additive regulation of hepatic gene expression by dwarfism and caloric restriction", Physiol Genomics, 17, pp.307~315 (2004)
  32. Amador-Noguez D, "Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice", Biochem Biophys Res Commun, 332, pp.1086~1100 (2005)
  33. Papaconstantinou J, "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice", Mech Ageing Dev, 126, pp.692~704 (2005)
  34. Boylston WH, "Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice", Age (Dordr), 28, pp.125~144 (2006)
  35. Rossner R, "Flavincontaining monooxygenases in aging and disease : Emerging roles for ancient enzymes", J Biol Chem, 292, pp.11138~11146 (2017)
  36. Simard J, "Molecular biology of the 3betahydroxysteroid dehydrogenase", delta5-delta4 isomerase gene family, 2005, pp.26, 525~582
  37. Jones JM, "Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases", J Biol Chem, 275, pp.12590~12597 (2000)
  38. Rowland JE, "In vivo analysis of growth hormone receptor signaling domains and their associated transcripts", Mol Cell Biol, 25, pp.66~77 (2005)
  39. Barclay JL, "GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism", Endocrinology, 152, pp.181~192 (2011)
  40. Chang L, "Integrated analysis of noncoding RNAs and mRNAs reveals their potential roles in the biological activities of the growth hormone receptor", Growth Horm IGF Res, 29, pp.11~20 (2016)
  41. Swindell WR, "Gene expression profiling of long-lived dwarf mice : longevity-associated genes and relationships with diet, gender and aging", BMC Genomics, 8, pp.353~ (2007)
  42. Nicola NA, "Leukemia inhibitory factor(LIF)", Cytokine Growth Factor Rev, 26, pp.533~544 (2015)
  43. Yano H, "Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome : neuroimmune-endocrine modulation of pituitary development", Mol Endocrinol, 12, pp.1708~1720 (1998)
  44. Niedernhofer LJ, "A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis", Nature, 444, pp.1038~1043 (2006)
  45. van der Pluijm I, "Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome", PLoS Biol, 5, pp.e2~ (2007)
  46. Schumacher B, "Delayed and accelerated aging share common longevity assurance mechanisms", PLoS Genet, 4, pp.e1000161~ (2008)
  47. Jansson JO, "Sexual dimorphism in the control of growth hormone secretion", Endocr Rev, 6, pp.128~150 (1985)
  48. MacLeod JN, "Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice", J Endocrinol, 131, pp.395~399 (1991)
  49. Mode A, "Sex and the liver-a journey through five decades", Drug Metab Rev, 38, pp.197~207 (2006)
  50. Waxman DJ, "Growth hormone regulation of sex-dependent liver gene expression", Mol Endocrinol, 20, pp.2613~2629 (2006)
  51. Yang X, "Tissue-specific expression and regulation of sexually dimorphic genes in mice", Genome Res, 16, pp.995~1004 (2006)
  52. Clodfelter KH, "Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b(STAT5b) : STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis", Mol Endocrinol, 20, pp.1333~1351 (2006)
  53. Clodfelter KH, "Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis", Physiol Genomics, 31, pp.63~74 (2007)
  54. Sjogren K, "Liver-derived insulin-like growth factor I(IGF-I)is the principal source of IGF-I in blood but is not required for postnatal body growth in mice", Proc Natl Acad Sci U S A, 96, pp.7088~7092 (1999)
  55. Conover CA, "Key questions and answers about pregnancy-associated plasma protein-A", Trends Endocrinol Metab, 23, pp.242~249 (2012)
  56. Conover CA, "Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development", Development, 131, pp.1187~1194 (2004)
  57. Conover CA, "Loss of pregnancyassociated plasma protein A extends lifespan in mice", Aging Cell, 6, pp.727~729 (2007)
  58. Conover CA, "Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A", J Gerontol A Biol Sci Med Sci, 65, pp.590~599 (2010)
  59. Liu JP, "Mice carrying null mutations of the genes encoding insulin-like growth factor I(Igf-1)and type 1IGF receptor(Igf1r)", Cell, 75, pp.59~72 (1993)
  60. Lorenzini A, "Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span", J Gerontol A Biol Sci Med Sci, 69, pp.410~419 (2014)
  61. Accili D, "Early neonatal death in mice homozygous for a null allele of the insulin receptor gene", Nat Genet, 12, pp.106~109 (1996)
  62. Nelson JF, "Probing the relationship between insulin sensitivity and longevity using genetically modified mice", J Gerontol A Biol Sci Med Sci, 67, pp.1332~1338 (2012)
  63. Yakar S, "Normal growth and development in the absence of hepatic insulin-like growth factor I", Proc Natl Acad Sci U S A, 96, pp.7324~7329 (1999)
  64. Svensson J, "Liver-derived IGF-I regulates mean life span in mice", PLoS One, 6, pp.e22640~ (2011)
  65. Novosyadlyy R, "Insulin-like growth factors and insulin : at the crossroad between tumor development and longevity", J Gerontol A Biol Sci Med Sci, 67, pp.640~651 (2012)
  66. Bokov AF, "Does reduced IGF-1R signaling in Igf1r+", - mice alter aging?, 2011, pp.6, e26891~
  67. Ladiges W, "Lifespan extension in genetically modified mice", Aging Cell, 8, pp.346~352 (2009)
  68. Kurosu H, "Suppression of aging in mice by the hormone Klotho", Science, 309, pp.1829~1833 (2005)
  69. Kuro-o M, "Mutation of the mouse klotho gene leads to a syndrome resembling ageing", Nature, 390, pp.45~51 (1997)
  70. Selman C, "Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice", FASEB J, 22, pp.807~818 (2008)
  71. Peng J, "IRS posttranslational modifications in regulating insulin signaling", J Mol Endocrinol, 60, pp.R1~R8 (2018)[DOI]
  72. Previs SF, "Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo", J Biol Chem, 275, pp.38990~38994 (2000)
  73. Selman C, "Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1", PLoS One, 6, pp.e16144~ (2011)
  74. Withers DJ, "Disruption of IRS-2 causes type 2 diabetes in mice", Nature, 391, pp.900~904 (1998)
  75. Kushner JA, "Pdx1 restores beta cell function in Irs2 knockout mice", J Clin Invest, 109, pp.1193~1201 (2002)
  76. Kushner JA, "Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice", Diabetes, 53, pp.61~66 (2004)
  77. Kushner JA, "Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis", J Biol Chem, 280, pp.39388~39393 (2005)
  78. Taguchi A, "Insulin-like signaling, nutrient homeostasis, and life span", Annu Rev Physiol, 70, pp.191~212 (2008)
  79. Taguchi A, "Brain IRS2 signaling coordinates life span and nutrient homeostasis", Science, 317, pp.369~372 (2007)
  80. Selman C, "Comment on"Brain IRS2 signaling coordinates life span and nutrient homeostasis"", Science, 320, pp.1012~ (2008)[DOI]
  81. Kubota N, "Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding", Cell Metab, 8, pp.49~64 (2008)
  82. Guo S, "The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis", Mol Cell Biol, 29, pp.5070~5083 (2009)
  83. Brunet A, "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor", Cell, 96, pp.857~868 (1999)
  84. Martins R, "Long live FOXO : unraveling the role of FOXO proteins in aging and longevity", Aging Cell, 15, pp.196~207 (2016)
  85. Hannenhalli S, "The evolution of Fox genes and their role in development and disease", Nat Rev Genet, 10, pp.233~240 (2009)
  86. Shimokawa I, "The life-extending effect of dietary restriction requires Foxo3in mice", Aging Cell, 14, pp.707~709 (2015)
  87. Boehm AM, "FoxO is a critical regulator of stem cell maintenance in immortal Hydra", Proc Natl Acad Sci U S A, 109, pp.19697~19702 (2012)
  88. Webb AE, "Characterization of the direct targets of FOXO transcription factors throughout evolution", Aging Cell, 15, pp.673~685 (2016)
  89. Page MM, "Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1(IRS1)in mice", Aging (Albany NY), 10, pp.1027~1052 (2018)
  90. Stout MB, "Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice", Aging (Albany NY), 6, pp.575~586 (2014)
  91. Stout MB, "Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice", Oncotarget, 6, pp.26702~26715 (2015)
  92. Masternak MM, "Metabolic effects of intra-abdominal fat in GHRKO mice", Aging Cell, 11, pp.73~81 (2012)
  93. Bluher M, "Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance", Dev Cell, 3, pp.25~38 (2002)
  94. Bluher M, "Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression", J Biol Chem, 279, pp.31891~31901 (2004)
  95. Katic M, "Mitochondrial gene expression and increased oxidative metabolism : role in increased lifespan of fat-specific insulin receptor knock-out mice", Aging Cell, 6, pp.827~839 (2007)
  96. Kappeler L, "Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism", PLoS Biol, 6, pp.e254~ (2008)
  97. Sadagurski M, "IRS2increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease", J Clin Invest, 121, pp.4070~4081 (2011)
  98. Li Q, "Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression", Aging Cell, 6, pp.799~806 (2007)
  99. Ren J, "Impaired cardiac excitation-contraction coupling in ventricular myocytes from Ames dwarf mice with IGF-I deficiency", Growth Horm IGF Res, 12, pp.99~105 (2002)
  100. Um SH, "Nutrient overload, insulin resistance, and ribosomal protein S6kinase 1, S6K1", Cell Metab, 3, pp.393~402 (2006)
  101. Selman C, "Ribosomal protein S6 kinase 1 signaling regulates mammalian life span", Science, 326, pp.140~144 (2009)
  102. Lamming DW, "Rapamycininduced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity", Science, 335, pp.1638~1643 (2012)
  103. Ranieri SC, "Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance", Proc Natl Acad Sci U S A, 107, pp.13420~13425 (2010)
  104. Migliaccio E, "The p66shc adaptor protein controls oxidative stress response and life span in mammals", Nature, 402, pp.309~313 (1999)
  105. Tomilov AA, "Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice", J Biol Chem, 285, pp.1153~1165 (2010)
  106. Wientjes FB, "NADPH oxidase and the respiratory burst", Semin Cell Biol, 6, pp.357~365 (1995)
  107. Dang CV, "MYC on the path to cancer", Cell, 149, pp.22~35 (2012)
  108. Hofmann JW, "Reduced expression of MYC increases longevity and enhances healthspan", Cell, 160, pp.477~488 (2015)
  109. Bartke A, "Healthy aging : is smaller better?-a mini-review", Gerontology, 58, pp.337~343 (2012)
  110. Wang S, "Obesity Paradox in Aging : From Prevalence to Pathophysiology", Prog Cardiovasc Dis, 61, pp.182~189 (2018)
  111. Murakami S, "Stress resistance in long-lived mouse models", Exp Gerontol, 41, pp.1014~1019 (2006)
  112. Tower J, "Sex-Specific Gene Expression and Life Span Regulation", Trends Endocrinol Metab, 28, pp.735~747 (2017)

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